Biological Evaluation of Synthesized Naringenin Derivatives as Antimicrobial Agents

Murti, Yogesh

doi:10.2174/2211352518999200729111045

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…Results of naringin were significantly worse comparing to naringenin. Some close derivatives of naringenin tested by Murti et al and Duda-Madej et al had surprisingly satisfying values (MIC ≤ 50 µg/mL) shown in the Scheme 2 a,b [ 67 , 80 ]. Beside in vitro measurements of MICs, there are a number of molecular and biochemical studies demonstrating the effect of this bioflavonoid on the Gram-negative bacterial cell.…”

Section: Antimicrobial Activity Against Gram-negative Bacteriamentioning

confidence: 99%

“…Although all of the derivatives showed antifungal activity, there are also moieties that may reduce it. The methoxy-substituted phenyl ring decreased the antifungal effect of naringenin [ 80 ]. According to the above-mentioned studies, different naringenin derivatives also have significant biological properties, some of them even greater than naringenin.…”

Section: Antifungal Activitymentioning

confidence: 99%

“…( a ) 1—7- O -methylnaringenin; 2—7- O -methylnaringenin oxime; 3—7,4′-di- O -methylnaringenin; 4—7,4′-di- O -methylnaringenin oxime; 5—7- O -ethylnaringenin; 6—7- O -ethylnaringenin oxime; 7—7- O -isopropylnaringenin; 8—7- O -isopropylnaringenin oxime; 9—7,4′-di- O -isopropylnaringenin; 10—7,4′-di- O -isopropylnaringenin oxime; 11—7- O -butylnaringenin; 12—7- O -butylnaringenin oxime; 13—7- O -pentylnaringenin; 14—7- O -pentylnaringenin oxime; 15—7- O -hexylnaringenin; 16—7- O -hexylnaringenin oxime; 17—7,4′-di- O -hexylnaringenin; 18—7,4′-di- O -hexylnaringenin oxime (based on Duda-Madej et al [ 67 ]). ( b ) based on Murti et al [ 80 ].…”

Section: Figures Schemes and Tablesmentioning

confidence: 99%

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Naringenin and Its Derivatives—Health-Promoting Phytobiotic against Resistant Bacteria and Fungi in Humans

et al. 2022

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Naringenin is a trihydroxyflavanone present in large amount in different citrus fruits, e.g., oranges, pomelos, grapefruits, but also in tomatoes, fenugreek and coffee. It has a wide range of pharmacological and biological effects beneficial to human health. Its antioxidant, anti-cancer, anti-inflammatory, antifungal and antimicrobial activity is frequently reported in scientific literature. In this review we presented the current state of knowledge on the antimicrobial activity of naringenin and its natural and synthetic derivatives as a phytobiotic against resistant Gram-positive and Gram-negative bacteria as well as fungi in humans. Most of the data reported here have been obtained from in vitro or in vivo studies. Over the past few years, due to the overuse of antibiotics, the occurrence of bacteria resistant to all available antibiotics has been growing. Therefore, the main focus here is on antibiotic resistant strains, which are a significant, worldwide problem in the treatment of infectious diseases. The situation is so alarming that the WHO has listed microbial resistance to drugs on the list of the 10 most important health problems facing humanity. In addition, based on scientific reports from recent years, we described the potential molecular mechanism of action of these bioflavonoids against pathogenic strains of microorganisms. As plant-derived substances have been pushed out of use with the beginning of the antibiotic era, we hope that this review will contribute to their return as alternative methods of preventing and treating infections in the epoch of drug resistance.

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Section: Antimicrobial Activity Against Gram-negative Bacteriamentioning

confidence: 99%

Section: Antifungal Activitymentioning

confidence: 99%

Section: Figures Schemes and Tablesmentioning

confidence: 99%

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Naringenin and Its Derivatives—Health-Promoting Phytobiotic against Resistant Bacteria and Fungi in Humans

et al. 2022

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In vitro and in silico antiproliferative potential of isolated flavonoids constitutes from Pistacia integerrima

Rauf,

Rashid,

Akram

et al. 2024

Zeitschrift Für Naturforschung C

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Cancer is one of the most demanding domains for innovative, effective, safe, and affordable therapeutically active chemicals. The main aim of this study is to research new phytochemicals with anticancer activity. The current experiment identified and analyzed six compounds for anti-cancer potential supported by molecular simulation studies. The defatted methanolic extract underwent column chromatography, resulting in the isolation of six flavonoids. These include 3,5,7,4′-tetrahydroxy-flavanone (1), naringenin (2), 3,5,4′-trihydroxy-7-methoxy-flavanone (3), sakuranetin (4), spinacetin (5), and patuletin (6). The isolated compounds (1–6) were assessed for in vitro anti-cancer activity against various cell lines such as HepG2 (hepatoma G2), A498 (kidney), NCI-H226 (lungs), and MDR2780AD (human ovarian). The maximum antiproliferative effect was against HepG2 and MDR2780AD. When compounds 6, 5, and 1 were compared to a standard anti-cancer medicine (paclitaxel) with an IC50 of 7.32, it was shown that compounds 6, 5, and 1 exhibited significant activity against HepG2 with IC50 values of 14.65, 20.87, and 27.09 µM, respectively. All tested compounds showed an IC50 of less than 1 µM and had notable effects against MDR2780 AD cell lines. Compound 6 exhibited notable potency against the HepG2, A498, and MDR2780AD cell lines, among the six compounds that were evaluated. In contrast, compound 3 demonstrated the most pronounced impact on the NCI-H226 cell line. Docking investigations were performed using tubulin as the specific target concerning PDB ID 4O2B. The six compounds under investigation interact hydrophobically and hydrophilically with tubulin-binding site amino acid residues.

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Review on Nutritional Potential of Underutilized Millets as a Miracle Grain

Singh,

Sharma,

Ramankutty

et al. 2024

CPB

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The current situation, which includes changes in eating habits, an increasing population, and the unrestricted use of natural resources, has resulted in a lack of resources that could be used to provide nourishing food to everyone. Natural plant resources are quickly being depleted, so it is necessary to consider new alternatives. In addition to the staple grains of rice and wheat, many other crops are being consumed that need to be utilized to their full potential and have the potential to replace the staple crops. Millets are one of the most important underutilized crops that have the potential to be used as a nutricereal. Millets have a high nutritional value, do not produce acids, do not contain gluten, and can contribute to a healthy diet. Due to a lack of awareness regarding the nutritional value of millets, their consumption is still restricted to the population that adheres to conventional diets and is economically disadvantaged even though millets contain a significant amount of nutrients. Millets are becoming increasingly unpopular due to a lack of processing technologies, food subsidies, and the inconvenience of preparing food with millets. Millets are a Nutricereal rich in carbohydrates, dietary fibers, energy, essential fatty acids, proteins, vitamin B, and minerals such as calcium, iron, magnesium, potassium, and zinc. These nutrients help to protect against post-translational diseases such as diabetes, cancer, cardiovascular disease, and celiac disease, among others. Millets are beneficial for controlling blood pressure, blood sugar level, and thyroid function; however, despite these functional properties, millets consumption has declined. Utilizing millets and other staple food crops to develop alternative food sources has become a new area of focus for businesses in the food industry. In addition, millet consumption can help foster immunity and health, which is essential in strengthening our fight against malnutrition in children and adolescents. In this article, the authors examine the potential of millets in terms of their nutricereal qualities.

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Biological Evaluation of Synthesized Naringenin Derivatives as Antimicrobial Agents

Cited by 5 publications

References 21 publications

Naringenin and Its Derivatives—Health-Promoting Phytobiotic against Resistant Bacteria and Fungi in Humans

Naringenin and Its Derivatives—Health-Promoting Phytobiotic against Resistant Bacteria and Fungi in Humans

In vitro and in silico antiproliferative potential of isolated flavonoids constitutes from Pistacia integerrima

Review on Nutritional Potential of Underutilized Millets as a Miracle Grain

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