Biological evaluation of integrin α3β1-targeted 68Ga-labeled HEVNPs in HCT 116 colorectal tumor-bearing mice

Lambidis, Elisavet; Chen, Chun‐Chieh; Lumén, Dave; Fraguas-Sánchez, Ana Isabel; Sarparanta, Mirkka; Cheng, R. Holland; Airaksinen, Anu J.

doi:10.1016/j.ejps.2022.106336

Cited by 1 publication

(1 citation statement)

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“… [ 28 ] 68Ga-labeled Hepatitis E virus NPs Integrin α3β1 PET HCT 116 CRC-bearing mice Internalization of NPs in HCT116 cells is improved significantly, but the specific targeting efficiency needs to be further improved. [ 29 ] Fe3O4/Au/Ag NPs Cytidine SERS Colon cancer-bearing mice Detection of nucleoside concentrations at the nM level. [ 30 ] Human heavy-chain ferritin (HFn) NPs Transferrin receptor 1 (TfR1) Endoscopy Gastric cancer-bearing mice Identification of early-stage gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Yue¹,

Xu²,

Xu³

et al. 2023

IJN

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The diagnosis of gastrointestinal (GI) diseases currently relies primarily on invasive procedures like digestive endoscopy. However, these procedures can cause discomfort, respiratory issues, and bacterial infections in patients, both during and after the examination. In recent years, nanomedicine has emerged as a promising field, providing significant advancements in diagnostic techniques. Nanoprobes, in particular, offer distinct advantages, such as high specificity and sensitivity in detecting GI diseases. Integration of nanoprobes with advanced imaging techniques, such as nuclear magnetic resonance, optical fluorescence imaging, tomography, and optical correlation tomography, has significantly enhanced the detection capabilities for GI tumors and inflammatory bowel disease (IBD). This synergy enables early diagnosis and precise staging of GI disorders. Among the nanoparticles investigated for clinical applications, superparamagnetic iron oxide, quantum dots, single carbon nanotubes, and nanocages have emerged as extensively studied and utilized agents. This review aimed to provide insights into the potential applications of nanoparticles in modern imaging techniques, with a specific focus on their role in facilitating early and specific diagnosis of a range of GI disorders, including IBD and colorectal cancer (CRC). Additionally, we discussed the challenges associated with the implementation of nanotechnology-based GI diagnostics and explored future prospects for translation in this promising field.

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