Biological Evaluation of Chelate-Setting Apatite Cement Using Inositol Phosphate

kida, kouki; Horiguchi, Yukiko; Oribe, Kazuya; Morisue, Hikaru; Matsumoto, Morio; Toyama, Yoshiaki; Aizawa, Mamoru

doi:10.4028/www.scientific.net/kem.361-363.335

Cited by 5 publications

(2 citation statements)

References 6 publications

(6 reference statements)

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“…The HAp particles are surfacemodified with the IP6 by chelating in pure water to form cements without the acidbase reaction above mentioned. 23) Kida et al 24) have shown that the IP6/HAp cement has non-cytotoxicity in vitro and that the bone-forming ability in vivo is comparable to the commercially available CPC (Biopex µ -R; HOYA, Japan); Biopex µ -R is well-used in the orthopedic surgery in Japan. This chelate-forming ability by IP6 may be applicable also to ¢-TCP.…”

Section: )12)mentioning

confidence: 99%

Fabrication of novel bioresorbable .BETA.-tricalcium phosphate cement on the basis of chelate-setting mechanism of inositol phosphate and its evaluation

Takahashi

Konishi

Nishiyama

et al. 2011

J. Ceram. Soc. Japan

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We have developed novel bioresorbable ¢-tricalcium phosphate (¢-TCP) cements on the basis of chelate-setting mechanism of inositol phosphate (IP6). The starting cement powders (IP6/¢-TCP powders) were prepared by surface-modifying ¢-TCP particles with IP6. The cement specimen was fabricated by mixing the IP6/¢-TCP powder in pure water at desired powder/ liquid ratios, and examined the effects of powder properties of the IP6/¢-TCP powder on the mechanical strength (compressive strength) of the cement specimens. We focused on the crystalline phase, particle size, specific surface area (SSA), and crystallite size among powder properties. The crystalline phase of resulting cement specimen was ¢-TCP single phase or mixture of ¢-TCP and calcium-deficient apatite (CDAp). The ¢-TCP cement with compressive strength of 13 MPa was fabricated from the finelyground ¢-TCP powders prepared by ball-milling commercially-available ¢-TCP powder for 4 h using zirconia beads with 10 mm in diameter. Meanwhile, the ¢-TCP/CDAp biphasic cement had maximum compressive strength of about 23 MPa among the examined cement specimens, it was fabricated from the ball-milled commercially-available ¢-TCP powder for 3 h using zirconia beads with 10 mm in diameter, and then for 3 h using zirconia beads with 2 mm in diameter. In order to make the determining factors of the compressive strength clear, we examined the relationship between powder properties (particle size, SSA and crystallite size) and compressive strength. The strength of the IP6/¢-TCP cement was not dependent on the particle size of the IP6/¢-TCP powder; meanwhile, the strength was enhanced with increasing SSA and decreasing crystallite size. Thus, the IP6/¢-TCP powder with higher SSA and smaller crystallite size may be useful in the fabrication of chelate-setting ¢-TCP cement with enhanced mechanical properties.

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Section: )12)mentioning

confidence: 99%

Fabrication of novel bioresorbable .BETA.-tricalcium phosphate cement on the basis of chelate-setting mechanism of inositol phosphate and its evaluation

Takahashi

Konishi

Nishiyama

et al. 2011

J. Ceram. Soc. Japan

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“…One of the present authors and his coworkers have developed a novel CPC based on the chelate-setting mechanism of inositol hexaphosphate (IP6) 3,4 .…”

Section: Introductionmentioning

confidence: 99%

EFFECTS OF ADDITION OF Α-Tricalcium PHOSPHATE POWDERS ON MATERIAL PROPERTIES OF THE CHELATE-SETTING HYDROXYAPATITE CEMENT

Kiminami

Matsuoka

Konishi

et al. 2017

Phosphorus Research Bulletin

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We have previously developed a chelate-setting calcium-phosphate cement (CPC) consisting of hydroxyapatite (HAp) powders surface-modified with inositol hexaphosphate (IP6). In the present study, mechanically ball-milled α-tricalcium phosphate (α-TCP) powders were added into the IP6-HAp cement in order to enhance its anti-washout capability and mechanical properties. After optimization of the ball-milling conditions, the cement specimens mixed with various amounts of the prepared α-TCP powders were fabricated. Examinations of their mechanical properties revealed significant increase of compressive strength (CS) with the addition of the α-TCP powders. Further, it was demonstrated that the specimens of the IP6-HAp powders / the α-TCP powders mixing ratios of 20/80 and 30/70 [g/g] exhibited comparatively high anti-washout capability. In conclusion, these cements are promising chelate-setting CPCs with enhanced anti-washout capability and mechanical properties.

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Characterization of a high strength hydroxyapatite cement with dual chelate‐setting using phytic acid and citric acid

Nie

Wang

et al. 2021

Int J Applied Ceramic Tech

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With the development of biomaterials, a hydroxyapatite (HA) bone cement based on chelation has gradually attracted attention. This paper presents an investigation on the micromorphology and mechanical property of HA bone cement prepared by HA powders modified by inositol hexaphosphate (IP6, phytic acid). With the citric acid monohydrate (CA) solution used as setting liquid, scanning electron microscopy (SEM) and universal testing machine were employed to investigate the influence of parameters including concentrations of CA as well as powder–liquid ratio on the properties of HA bone cement. In addition, the setting mechanism of chelating cement was analyzed. The results showed that when CA concentration was more than 20 wt.%, the curing products of IP6/CA dual chelating HA cement contained calcium citrate tetrahydrate and tricalcium phosphate (TCP) besides HA. The compressive strength of dual chelated cement increased with the CA concentration. With 10 000 ppm‐IP6‐HA used as the starting powder, the maximum compressive strength of bone cement prepared with 40 wt.% CA as the setting liquid was up to 57 MPa. Furthermore, the temperature, pH, antibacterial activity measurement, and cell studies in vitro were carried on, suggesting that chelate‐setting HA cement has potential development in orthopedic materials.

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Biological Evaluation of Chelate-Setting Apatite Cement Using Inositol Phosphate

Cited by 5 publications

References 6 publications

Fabrication of novel bioresorbable .BETA.-tricalcium phosphate cement on the basis of chelate-setting mechanism of inositol phosphate and its evaluation

Fabrication of novel bioresorbable .BETA.-tricalcium phosphate cement on the basis of chelate-setting mechanism of inositol phosphate and its evaluation

EFFECTS OF ADDITION OF Α-Tricalcium PHOSPHATE POWDERS ON MATERIAL PROPERTIES OF THE CHELATE-SETTING HYDROXYAPATITE CEMENT

Characterization of a high strength hydroxyapatite cement with dual chelate‐setting using phytic acid and citric acid

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