Biological effects of verbascoside and its anti-inflammatory activity on oral mucositis: a review of the literature

Abstract

Oral mucositis is among the most common tissue toxicities associated with both cytotoxic cancer regimens and head and neck radiotherapy. Current management of oral mucositis might comprise growth factors and cytokines, anti-inflammatory agents, anesthetics, analgesics, antimicrobial and coating agents, cryotherapy and mucosal protectants. Despite its long history and its impact on patients, there are currently no effective options for the prevention or treatment of mucositis. In recent years, more attention has been focused on the role of natural drugs. Verbascoside belongs to the phenylpropanoid glycosides family. Several biological properties have been described, such as anti-inflammatory, antimicrobial, antitumor and antioxidant. Verbascoside, particularly when in solution with polyvinylpyrrolidone and sodium hyaluronate, thanks to barrier effect, is useful in re-epithelialization and in reducing pain, oral mucositis score, burning and erythema.

Comparative metabolomics analysis of different sesame (Sesamum indicum L.) tissues reveals a tissue-specific accumulation of metabolites

“…Verbascoside also has been identified in sesame leaves [20]. Acteoside, isoacteoside, and verbascoside possess various pharmacological proprieties, including antiinflammatory, anti-cancer, antioxidative, neuroprotective, anti-diabetes, anti-hypertensive, anti-microbial, and antitumours [52][53][54][55]. Sesamin, one of the major sesame lignan, was detected only in fresh seeds and fresh carpels with the highest relative content in FS.…”

Integrated Phytochemical Analysis Based on UPLC–MS/MS and Network Pharmacology Approaches to Explore the Effect of Odontites vulgaris Moench on Rheumatoid Arthritis

“…The primary compounds present in O. vulgaris are phenylethanol glycosides, iridoids, and flavonoids. Some compounds have been shown to have certain anti-inflammatory effects (Gong et al, 2020;Nigro et al, 2020;Wang et al, 2020d;Cicek et al, 2021;Tian et al, 2021). Through interviews with the local populace and hospital personnel in Inner Mongolia, we found that O. vulgaris is often used to treat RA; therefore, we conducted an in-depth study on the effects of O. vulgaris on RA.…”

The effects of herbal medicines on cancer therapy‐induced oral mucositis: A literature review

“…Considering the harmful effects of chemical agents, herbal medicine with unique properties such as natural, inexpensive, available and accessible, and well-accepted without any considerable adverse effects has attracted considerable attention recently. Several beneficial properties are attributed to the medicinal plants, including antiinflammatory, antibacterial, antiviral, anti-fungal, and antioxidant activities (Nigro et al, 2020;Yarom et al, 2020). Herbal medicine and medicinal plants are also traditionally known as safe remedies for dental and oral diseases.…”

“…Many studies have shown positive effects for nutraceuticals and medicinal plants on different adverse effects related to cancers or cancer therapies. The beneficial effects of herbal medicines such as antioxidative and anti-inflammatory activities have been established (Nigro et al, 2020;Yarom et al, 2020). However, to the authors' knowledge, to date, there is no study to review and summarize the effects of herbal medicines on cancer therapy-induced OM.…”