Biological Effects and the Medical Usage of Olive Leaves

Armutçu, Ferah; Akyol, Sümeyya; Hasgül, Rukiye; Yiğitoğlu, M. Ramazan

doi:10.5455/spatula.20111013104724

Cited by 6 publications

(7 citation statements)

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“…Olea europaea leaves have been widely used in traditional remedies in European and Mediterranean countries for their bioactive compounds. Several active phenolic compounds in unprocessed olive leaves such as oleuropein and hydroxytyrosol and other flavonoids have been identified [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway

et al. 2017

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Dietary polyphenols, derived from natural products, have received a great interest for their chemopreventive properties against cancer. In this study, we investigated the effects of phenolic extract of the oleaster leaves (PEOL) on tumor growth in mouse model and on cell death in colon cancer cell lines. We assessed the effect of oleaster leaf infusion on HCT116 (human colon cancer cell line) xenograft growth in athymic nude mice. We observed that oleaster leaf polyphenol-rich infusion limited HCT116 tumor growth in vivo. Investigations of PEOL on two human CRC cell lines showed that PEOL induced apoptosis in HCT116 and HCT8 cells. We demonstrated an activation of caspase-3, -7 and -9 by PEOL and that pre-treatment with the pan-caspase inhibitor, N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (z-VAD-fmk), prevented PEOL-induced cell death. We observed an involvement of the mitochondrial pathway in PEOL-induced apoptosis evidenced by reactive oxygen species (ROS) production, a decrease of mitochondrial membrane potential, and cytochrome c release. Increase in intracellular Ca2+ concentration induced by PEOL represents the early event involved in mitochondrial dysfunction, ROS-induced endoplasmic reticulum (ER) stress and apoptosis induced by PEOL, as ruthenium red, an inhibitor of mitochondrial calcium uptake inhibited apoptotic effect of PEOL, BAPTA/AM inhibited PEOL-induced ROS generation and finally, N-acetyl-L-cysteine reversed ER stress and apoptotic effect of PEOL. These results demonstrate that polyphenols from oleaster leaves might have a strong potential as chemopreventive agent in colorectal cancer.

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Section: Introductionmentioning

confidence: 99%

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway

et al. 2017

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“…The nanoparticles synthesized from plant extracts were found to be covered by the medicinal properties of the plant extract, which could be used in drug, targeted drug delivery, and cosmetic applications . Olive ( Olea europaea ) tree leaves contain many potentially bioactive compounds that may have antioxidant, antihypertensive, antiatherogenic, antirheumatic, and anti‐inflammatory properties . The primary medical constituents of olive leaf are believed to have antioxidants, such as oleuropein and hydroxytyrosol, as well as other flavonoids, which are the most common group of polyphenolics in the human diet.…”

Section: Introductionmentioning

confidence: 99%

“…12 Olive (Olea europaea) tree leaves contain many potentially bioactive compounds that may have antioxidant, 13 antihypertensive, 14 antiatherogenic, 15 antirheumatic, 16 and anti-inflammatory properties. 17 The primary medical constituents of olive leaf are believed to have antioxidants, such as oleuropein and hydroxytyrosol, as well as other flavonoids, which are the most common group of polyphenolics in the human diet. The antioxidant effects of olive leaves protect the body from the continuous activity of free radicals.…”

mentioning

confidence: 99%

Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

Sulaiman

Tawfeeq

Jaaffer

2017

Biotechnology Progress

112

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Copper oxide nanoparticles (CUNPs) were synthesized using Olea europaea leaf extract as reducing and protecting agent. The formation of nanoparticles was observed through a color change from yellowish to brownish black. The CUNPs were confirmed with UV-Vis spectrophotometer, which revealed a peak absorbance at 289 nm. The synthesized CUNPs were characterized by XRD, FTIR, SEM, and TEM. The XRD pattern revealed that CUNPs were crystalline in nature with a diameter around 20 nm. FTIR spectral analysis showed that CUNPs were capped with plant constituents. From SEM and TEM analyses, the CUNPs were generally found to be spherical in shape, and the size range was 20-50 nm. Free radical scavenging potential of CUNPs against DPPH was confirmed by its stable antioxidant effects. In addition, the toxicity of CUNPs in mice was also assessed by body weight and weights of liver, kidneys, spleen, and thymus. The immune response in mice was signaled through an obvious change in spleen and thymus index, with a decrease of ADA enzyme activity in serum, spleen, and thymus after CUNPs treatment. The CUNPs were found to exert cell growth arrest against AMJ-13 and SKOV-3 cancer cells in a dose-dependent manner and induce cell death by apoptosis. Less significant cytotoxic effect was observed in normal dermal fibroblast cells. These findings suggest that CUNPs may have the potential to be anticancer agents. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:218-230, 2018.

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“…Olive oil and olive fruit is an important component of Mediterranean diet, and products associated with olive tree are known to provide commercial products such as food, cosmetics and medicine. Oleuropein is the most prominent phenolic compound found both in the fruit and leaves of olives (4,10,11) and is the cause of characteristic bitterness of green olive fruits (12). Phenolic compounds are found in all parts of the olive plant and can reach concentrations of up to 140 mg/g on a dry matter basis in young olives and 60-90 mg/g of dry matter in the leaves (4).…”

Section: Discussionmentioning

confidence: 99%

“…This effect is seen in prolonged exposure and as the extract contains numerous chemicals this effect can be attributed to various substances (10,13). Primary medical constituents contained in unprocessed olive leaf are oleuropein, hydroxytyrosols and many other flavonoids (10). Oleuropein has been shown to have strong antimicrobial activity against gram-negative and positive bacteria.…”

Section: Discussionmentioning

confidence: 99%

Protoscolicidal effect of oleuropein: an in vitro study

Arslan¹,

Özant²,

Özçay³

et al. 2019

Turk J Surg

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Objective: Hydatid disease is a parasitic disease caused by Echinococcus granulosus and is still endemic in many parts of the world. Scolicidal solutions are generally used in any type of intervention, either surgical or percutaneous, to neutralize the cyst contents, although completeness of their effect is obscure and solid evidence is scarce. On the other hand, the use of these scolicidal solutions is not devoid of complications and many serious complications such as caustic sclerosing cholangitis may be seen in relation with their usage. Recent investigations proved protoscolicidal properties of olive leaf extract although the active ingredient has not been attributed to any component. The aim of this experimental study was to isolate oleuropein and test for in vitro protoscolicidal activity. Material and Methods: Oleuropein, a phenolic compound found in olive leaves, is extracted and prepared in different concentrations. Echinococcal cyst containing livers of sheep are obtained from the government slaughterhouse. Cysts were punctured and live protoscolex suspensions were prepared under aseptic conditions. Different concentrations of oleuropein solutions were prepared and protoscolicidal property is analyzed and compared with positive and negative controls for different exposure times. Results: Oleuropein 2% concentration was found to be protoscolicidal in all exposure times starting from 5 minutes. Conclusion: 2% oleuropein is a powerful, natural protoscolicidal agent which should be evaluated clinically before its application in routine treatment practice.

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Biological Effects and the Medical Usage of Olive Leaves

Cited by 6 publications

References 0 publications

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway

Biogenic synthesis of copper oxide nanoparticles using olea europaea leaf extract and evaluation of their toxicity activities: An in vivo and in vitro study

Protoscolicidal effect of oleuropein: an in vitro study

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