Biological Effect of Hydrolyzed Collagen on Bone Metabolism

Abstract

Osteoporosis is a chronic and asymptomatic disease characterized by low bone mass and skeletal microarchitectural deterioration, increased risk of fracture, and associated comorbidities most prevalent in the elderly. Due to an increasingly aging population, osteoporosis has become a major health issue requiring innovative disease management. Proteins are important for bone by providing building blocks and by exerting specific regulatory function. This is why adequate protein intake plays a considerable role in both bone development and bone maintenance. More specifically, since an increase in the overall metabolism of collagen can lead to severe dysfunctions and a more fragile bone matrix and because orally administered collagen can be digested in the gut, cross the intestinal barrier, enter the circulation, and become available for metabolic processes in the target tissues, one may speculate that a collagen-enriched diet provides benefits for the skeleton. Collagen-derived products such as gelatin or hydrolyzed collagen (HC) are well acknowledged for their safety from a nutritional point of view; however, what is their impact on bone biology? In this manuscript, we critically review the evidence from literature for an effect of HC on bone tissues in order to determine whether HC may represent a relevant alternative in the design of future nutritional approaches to manage osteoporosis prevention.

Effect of Collagen Hydrolysates from Silver Carp Skin (Hypophthalmichthys molitrix) on Osteoporosis in Chronologically Aged Mice: Increasing Bone Remodeling

“…The beneficial anabolic effect of PTH administration on bone in various animal models and humans has been proved [ 8 ]. However, it has been emphasized that compliance to such therapy tends to be poor and benefit does not continue after ending treatment [ 9 ]. Besides, the long-term application of anti-osteoporotic drugs comes with serious side effects [ 10 ].…”

“…As the major structural element in the extracellular matrix of all connective tissues, collagens represent about 80% of the total protein [ 13 ]. Collagens form the scaffold for the attachment of cells and the anchorage of macromolecules and minerals [ 9 ]. Furthermore, bone collagens can bind and store growth factors and cytokines, such as insulin like growth factor (IGF) I and II, which are released during bone degradation and in turn promote bone formation.…”

The Influence of Biofield Energy Treated Vitamin D<sub>3</sub> on Bone Health and Its Health Consequences in MG-63 Cell-Line

“…Numerous scientific studies reported that osteoporosis has become a major health issue. Proteins more specifically collagen, plays a considerable role in both bone development and bone maintenance [46,47]. Here, the Biofield Energy Treated vitamin D 3 significantly improved the level of collagen which might be helpful to maintain a healthy bone in postmenopausal women selectively.…”

Effect of Biofield Energized Vitamin D<sub>3</sub> on Bone Health in MG-63 Cell-Line

“…Collagen, the source of fibers is the most abundant constituent of all the connective tissue. Various evidence reported that collagen, plays a considerable role in both bone development and bone maintenance [45,46]. ATF4, a transcription factor that stimulates amino-acid uptake and collagen synthesis in osteoblast.…”