Biological Desorption Electrospray Ionization Mass Spectrometry (DESI MS) – unequivocal role of crucial ionization factors, solvent system and substrates

Muthu, Manikandan; Kazibwe, Zakayo; Hasan, Nazim; Deenadayalan, Anbarasu; Gopal, Judy; Pradeep, Thalappil; Chun, Sechul

doi:10.1016/j.trac.2016.02.013

Cited by 20 publications

(13 citation statements)

References 83 publications

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“…Transferring analysis parameters from PTFE spots to leaves was the most complex part of the project. Influence of surface regarding LOD/LOQ, signal stability, possible carryover, and reproducibility are well‐known issues …”

Section: Resultsmentioning

confidence: 99%

Ambient mass spectrometry: Direct analysis of dimethoate, tebuconazole, and trifloxystrobin on olive and vine leaves by desorption electrospray ionization interface

et al. 2017

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A new field of application for a relatively new mass-spectrometric interface such as desorption electrospray ionization was evaluated. For this purpose, its behavior was tested versus quantitative analysis of dimethoate, trifloxystrobin, and tebuconazole directly on olive and vine leaves surface. The goal was workers exposure assessment during field re-entry operations since evidence suggests an association between chronic occupational exposure to some agrochemicals and severe adverse effects. Desorption electrospray ionization gave good response working in positive ionization mode, while numerous test were necessary for the choice of a unique blend of spray solvents suitable for all 3 substances. The best compromise, in terms of signal to noise ratios, was obtained with the CH OH/H O (80:20) mixture. The obvious difficulties related to the impossibility to use the internal standard were overcome through an accurate validation. Limits of detection and quantitation, dynamic ranges, matrix effects, and intraday precisions were calculated, and a small monitoring campaign was arranged to test method applicability and to evaluate potential dermal exposure. This protocol was developed in work safety field, but after a brief investigation, it was find to be suitable also for food residue evaluation.

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Section: Resultsmentioning

confidence: 99%

Ambient mass spectrometry: Direct analysis of dimethoate, tebuconazole, and trifloxystrobin on olive and vine leaves by desorption electrospray ionization interface

et al. 2017

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“…In most of the DESI-MS experiment, water, methanol, acetonitrile, dichloromethane and their mixtures are o en used as the spray solvents. 9) e extraction e ciency greatly depends on the polarity of solvents. In fact, nding an appropriate solvent system is important to obtain the optimal signal readouts for di erent classi cation of target molecules.…”

Section: Desorption Electrospray Ionization (Desi)mentioning

confidence: 99%

Clinical Application of Ambient Ionization Mass Spectrometry

Hsieh

Hsu

2017

Mass Spectrometry

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Ambient ionization allows mass spectrometry analysis directly on the sample surface under atmospheric pressure with almost zero sample pretreatment. Since the development of desorption electrospray ionization (DESI) in 2004, many other ambient ionization techniques were developed. Due to their simplicity and low operation cost, rapid and on-site clinical mass spectrometry analysis becomes real. In this review, we will highlight some of the most widely used ambient ionization mass spectrometry approaches and their applications in clinical study.

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“…Some of the important parameters which determine the ion signals in DESI-MS are incident angle of spray, collection angle of secondary droplets, distance between sprayer and surface, composition and ow rate of spray solvent, and type of surface. 107) Over the years, DESI-MS has been applied in wide areas such as forensics, 106,108) biology, [109][110][111] chemistry, [112][113][114][115][116] imaging, 117,118) and cancer diagnostics. [119][120][121][122] Another related technique known as desorption sonic-spray ionization (DeSSI) 123) also uses the desorption phenomena like DESI.…”

Section: Desorption Based Esimentioning

confidence: 99%

Electrospray Modifications for Advancing Mass Spectrometric Analysis

Meher

Chen

2017

Mass Spectrometry

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Generation of analyte ions in gas phase is a primary requirement for mass spectrometric analysis. One of the ionization techniques that can be used to generate gas phase ions is electrospray ionization (ESI). ESI is a so ionization method that can be used to analyze analytes ranging from small organics to large biomolecules. Numerous ionization techniques derived from ESI have been reported in the past two decades.ese ion sources are aimed to achieve simplicity and ease of operation. Many of these ionization methods allow the exibility for elimination or minimization of sample preparation steps prior to mass spectrometric analysis. Such ion sources have opened up new possibilities for taking scienti c challenges, which might be limited by the conventional ESI technique. us, the number of ESI variants continues to increase. is review provides an overview of ionization techniques based on the use of electrospray reported in recent years. Also, a brief discussion on the instrumentation, underlying processes, and selected applications is also presented.

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Biological Desorption Electrospray Ionization Mass Spectrometry (DESI MS) – unequivocal role of crucial ionization factors, solvent system and substrates

Cited by 20 publications

References 83 publications

Ambient mass spectrometry: Direct analysis of dimethoate, tebuconazole, and trifloxystrobin on olive and vine leaves by desorption electrospray ionization interface

Ambient mass spectrometry: Direct analysis of dimethoate, tebuconazole, and trifloxystrobin on olive and vine leaves by desorption electrospray ionization interface

Clinical Application of Ambient Ionization Mass Spectrometry

Electrospray Modifications for Advancing Mass Spectrometric Analysis

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