Clinical Application of Ambient Ionization Mass Spectrometry

Li, Lihua; Hsieh, Hua-Yi; Hsu, Cheng-Chih

doi:10.5702/massspectrometry.s0060

Cited by 34 publications

(32 citation statements)

References 103 publications

(131 reference statements)

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“…Here, metastable species are generated from an excited helium gas stream. The species subsequently react with analytes to form gaseous ions [32][33][34][35]. The main parameters that are known to affect the ionization efficiency of DART include desorption temperature, gas type, gas flow rate, discharge energy and angular disposal of the sampler, among others [33,35].…”

Section: Analytical Techniquesmentioning

confidence: 99%

“…Over the last decade, the application field of the DART-MS technique has seen extraordinary expansion. The technique has gained popularity among researchers and has been considered suitable for the following: olive oil authenticity assessment [36], pesticide monitoring on fruits [37] and vegetables [38], metabolite fingerprinting [39], plant seed characterization [40], clinical [35], pharmaceutical [41], forensic [42] and environmental [43] analyses, and for the detection of adulteration in foods such as milk [44] and honey [45].…”

Section: Analytical Techniquesmentioning

confidence: 99%

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An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

Pérez-Rodríguez

Pellerano

Pezza

et al. 2018

Talanta

135

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Tetracyclines are widely used for both the treatment and prevention of diseases in animals as well as for the promotion of rapid animal growth and weight gain. This practice may result in trace amounts of these drugs in products of animal origin, such as milk and eggs, posing serious risks to human health. The presence of tetracycline residues in foods can lead to the transmission of antibiotic-resistant pathogenic bacteria through the food chain. In order to ensure food safety and avoid exposure to these substances, national and international regulatory agencies have established tolerance levels for authorized veterinary drugs, including tetracycline antimicrobials. In view of that, numerous sensitive and specific methods have been developed for the quantification of these compounds in different food matrices. One will note, however, that the determination of trace residues in foods such as milk and eggs often requires extensive sample extraction and preparation prior to conducting instrumental analysis. Sample pretreatment is usually the most complicated step in the analytical process and covers both cleaning and pre-concentration. Optimal sample preparation can reduce analysis time and sources of error, enhance sensitivity, apart from enabling unequivocal identification, confirmation and quantification of target analytes. The development and implementation of more environmentally friendly analytical procedures, which involve the use of less hazardous solvents and smaller sample sizes compared to traditional methods, is a rapidly increasing trend in analytical chemistry. This review seeks to provide an updated overview of the main trends in sample preparation for the determination of tetracycline residues in foodstuffs. The applicability of several extraction and clean-up techniques employed in the analysis of foodstuffs, especially milk and egg samples, is also thoroughly discussed.

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Section: Analytical Techniquesmentioning

confidence: 99%

Section: Analytical Techniquesmentioning

confidence: 99%

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

Pérez-Rodríguez

Pellerano

Pezza

et al. 2018

Talanta

135

View full text Add to dashboard Cite

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“…The complex samples were usually prepared into clean solution and then was introduced into a capillary with the assistance of sheath gas in conventional ESI‐MS. With the development of ambient MS, novel ESI‐based ionization techniques such as desorption ESI (DESI) and extractive ESI (EESI) coupled with MS analysis for direct analysis of complex samples have been emerged in recent years, and among of those have been successfully applied in clinical diagnostics and other clinical measurements . In the late 1990s, Hong et al firstly developed a noncapillary ESI method in which the capillary was replaced by a metal wire for loading samples.…”

Section: Introductionmentioning

confidence: 99%

“…With the development of ambient MS, novel ESI-based ionization techniques such as desorption ESI (DESI) and extractive ESI (EESI) coupled with MS analysis for direct analysis of complex samples have been emerged in recent years, [13][14][15] and among of those have been successfully applied in clinical diagnostics and other clinical measurements. 16,17 In the late 1990s, Hong et al 18 firstly developed a noncapillary ESI method in which the capillary was replaced by a metal wire for loading samples. In the noncapillary ESI, the sample was directly loaded on solid substrate or the bulk sample itself was applied as ESI tip under the strong electric field without the use of sheath gas.…”

Section: Introductionmentioning

confidence: 99%

High‐throughput polymer tip‐electrospray ionization mass spectrometry for enhanced detection of neopterin and biopterin in clinical urine samples

et al. 2019

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Urinary biopterin (Bio) and neopterin (Neo) are important markers for clinical diagnosis of hyperphenylalaninemia. Herein, we developed a high‐throughput analysis method based on electrospray ionization mass spectrometry (ESI‐MS) with polymer tips for the rapid quantitative detection of Bio and Neo in clinical urine samples. Different polymer tips were investigated. It is found that the best detection sensitivity was achieved with hydrophobic polymer tip, ie, polyethylene tips. The high‐throughput polymer tip‐ESI‐MS method allowed a rapid analysis speed at ~40 seconds per sample. The limits of quantification (LOQ) (S/N ≥ 10) for the detection of Bio and Neo were improved to be 5.0 ng/mL. Acceptable relative standard deviation (RSD) values for Neo and Bio were measured to be 12.2% and 13.4% for direct measurement of Bio and Neo in raw urine samples, respectively. Furthermore, Bio and Neo were directly quantified from 18 clinical urine samples by presented method. The ratios of urinary Bio‐to‐Neo were analyzed for diagnosis of hyperphenylalaninemia. The results demonstrated that the present polymer tip‐ESI‐MS method is a promising strategy for the rapid analysis of clinical samples.

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“…6) With a direct and ambient ionization method, MS has been proven to be applicable to medical diagnosis with accelerated speed and accuracy. [7][8][9][10][11][12] Ambient MS or ambient ionization MS can be performed by replacing the original ion source of a commercial mass spectrometer with a custom-made electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI) variant. [13][14][15] To maximize the ion transmission to the vacuum of the mass spectrometer, the ionization is usually performed in close proximity to the ion inlet.…”

Section: Remote Ambient Mass Spectrometrymentioning

confidence: 99%

Towards Practical Endoscopic Mass Spectrometry

et al. 2017

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In this paper, we brie y review the remote mass spectrometric techniques that are viable to perform "endoscopic mass spectrometry," i.e., in-situ and in-vivo MS analysis inside the cavity of human or animal body. We also report our experience with a moving string sampling probe for the remote sample collection and the transportation of adhered sample to an ion source near the mass spectrometer. With a miniaturization of the probe, the method described here has the potential to be t directly into a medical endoscope.

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Clinical Application of Ambient Ionization Mass Spectrometry

Cited by 34 publications

References 103 publications

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

High‐throughput polymer tip‐electrospray ionization mass spectrometry for enhanced detection of neopterin and biopterin in clinical urine samples

Towards Practical Endoscopic Mass Spectrometry

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