Biological Damage Threshold Induced by Ultrashort Fundamental, 2nd, and 4th Harmonic Light Pulses from a Mode-Locked Nd: Glass Laser.

Near-Infrared Ultrashort Pulse Laser Bioeffects Studies

“…hi this study we compare our results with fliose for botii near-IR and visible wavelengttm previoiwly reported [12], [15], [16], [14], [17], [13], [19], [7] Laser-ocular tissue interaction studio for pulse widths below 1 ns are critical to the development of safety standard [50], [51], and in identifying hazanis to the human eye from those systenB presently operating in the near-IR reghne. An understanding of l^er-tissue interactions is b^ic to identifying the potential for injury and to applying therapeutic medical treatments to laser injury and disease.…”

“…In this study we are reporting retinal damage thresholds for single laser pulses of near-infrared wavelengths and comparing our resuhs with those for both near-infi-ared and visible wavelengths previously reported. [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23] We have determined the threshold dosages for ophthalmoscopically minimal visible lesions (MVL-ED50) for pulse widths of 150 femtoseconds (fs), 1, 20, and 80 picoseconds (ps) and 7 nanoseconds (ns) and the fluorescein angiography threshold dosages at one-hour and 24-hours post exposure. We have previously reported retinal injury studies of visible wavelengths for pulse widths down to 90 fs for pigmented rabbit eyes [24], [25] and for rhesus monkey eyes.…”

Origin of retinal pigment epithelium cell damage by pulsed laser irradiance in the nanosecond to microsecond time regimen

“…Griess et al reported of a cumulative effect for pulse durations of 16 nsec when applying between 1 and 100 pulses with 10 Hz [38]. Bruckner et al [39] reported a comparable dependence for picoseconds, and Stolarski et al [40] for 130 femtosecond pulse durations.…”

Artificial eye for in vitro experiments of laser light interaction with aqueous media

“…where r l is the radius of the beam at the principal plane of the lens. The value of M 2 gives an important property of the beam in terms of the diffraction-limited beam size. The radius of the focused beam at the minimum waist, r 0 , is given by:…”

“…There are numerous dose-response studies that determined the minimum laser energy required to produce retinal damage as a function of wavelength, 1,2 pulse width, [3][4][5][6][7] and repetitive pulses. 8,9 These studies were performed with various lasers and exposure conditions, yet there were consistent trends in the data that reflected a commonness in the animal models used.…”