Biological correlates of tumor perfusion and its heterogeneity in newly diagnosed breast cancer using dynamic first-pass 18F-FDG PET/CT

Payan, Neree; Presles, Benoît; Brunotte, François; Coutant, Charles; Desmoulins, Isabelle; Vrigneaud, Jean-Marc; Cochet, Alexandre

doi:10.1007/s00259-019-04422-4

Cited by 13 publications

(10 citation statements)

References 46 publications

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“…18 F-fluorodeoxyglucose ( 18 F-FDG) PET/CT imaging can estimate the state of glucose metabolism in tumors [22][23][24][25][26]. A high standard uptake value (SUVmax) has been shown to correlate with the malignancy of multiple tumors [27][28][29]. 18 F-FDG PET imaging is based on the high metabolic rate of glucose in tumor cells, and this mechanism of increase in glucose consumption and aerobic glycolysis in tumor cells is called the Warburg effect [30,31].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of METTL3 associated with the metabolic status on ¹⁸F-FDG PET/CT in patients with Esophageal Carcinoma

et al. 2020

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Background: To investigate the expression of methyltransferase 3 (METTL3) and its relationship with 18 F-FDG uptake in patients with esophageal carcinoma (ESCA). Materials and methods:This study analyzed the expression of METTL3 in ESCA and its relationship with clinicopathological features by The Cancer Genome Atlas (TCGA) database. Immunohistochemical staining was performed on 57 tumor tissues of ESCA patients who underwent PET/CT scan before surgery to evaluate the expression of METTL3, glucose transporter 1 (GLUT1), and hexokinase 2 (HK2) in tumor tissues and peritumoral tissues. Analyze the relationship between SUVmax with METTL3, HK2, and GLUT1 expression. Results: The expression of METTL3, GLUT1, and HK2 was significantly increased in ESCA tissues compared with normal tissues (p < 0.001). The expression of METTL3 was correlated with tumor size and histological differentiation (p < 0.05), and there was no significant difference between age, sex, pathological types, tumor staging, or lymph node metastasis (p > 0.05). The SUVmax was significantly higher in tumors with high METTL3 expression (17.822±6.249) compared to low METTL3 expression (9.573±5.082) (p < 0.001). There was a positive correlation between the SUVmax and METTL3 expression in ESCA (r 2 = 0.647, p < 0.001). Multivariate analysis confirmed the association between SUVmax and METTL3 expression (p < 0.05). GLUT1 and HK2 expression in ESCA was positively correlated with 18 F-FDG uptake and METTL3 status (p < 0.001). Conclusions: The high expression of METTL3 is related to the high SUVmax in ESCA, and METTL3 may increase 18 F-FDG uptake by regulating GLUT1 and HK2.

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Section: Introductionmentioning

confidence: 99%

Overexpression of METTL3 associated with the metabolic status on ¹⁸F-FDG PET/CT in patients with Esophageal Carcinoma

et al. 2020

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“…There were no significant differences in total blood flow values depending on tumor metabolism. The heterogeneity of perfusion correlated well with the heterogeneity of metabolism; therefore, it is possible that blood flow and consequently, tumor angiogenesis can cause heterogeneity of metabolic processes [ 23 ].…”

Section: Vascularization As a Predictor At Cancermentioning

confidence: 99%

Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization

Maiborodin

Mansurova

Chernyavskiy

et al. 2022

JPM

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Based on the study of recent scientific literature devoted to neovascularization and angiogenesis in malignant neoplasms, it was concluded that there are many publications on each of the problems of tumor angiogenesis and vascularization. The formation of blood vessels in a tumor and certain aspects of the prognostic value of the severity of vascularization in almost all forms of cancer are considered. Special attention is paid to the peculiarities of angiogenesis in tumors of the female reproductive system. A large number of vessels in the tumor often indicates a poor prognosis. The influence of various factors on the initiation of angiogenesis and the process itself, as well as the possibility of suppressing such signals to slow down the formation of blood vessels and thus the development of the tumor are widely studied. The results of pharmacological suppression of tumor vessel formation demonstrate a good clinical outcome but one accompanied by a large number of severe adverse side effects. Such a significant amount of studies on each of the problems of tumor vascularization indicates the increasing importance of this area of oncology. At the same time, only a very small number of works are devoted to the study of the differences in angiogenesis and number of vessels between different parts of the tumor, as well as between the primary tumor node and its metastases. The refinement of the results is still to be done. It was noted that the expression of proangiogenic factors in metastases is usually higher than in the source of metastasis, and the expression in lymphogenous metastases is higher than in hematogenous ones.

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“…We evaluated 20 publications on breast cancer [59,[188][189][190][191][192][193][194][195][196][197][198][199][200][201][202][203][204][205][206], all of them using FDG as the radiotracer. The average number of patients was 118 (median = 81, range, 34-435).…”

Section: Breast Cancermentioning

confidence: 99%

A Systematic Review of PET Textural Analysis and Radiomics in Cancer

et al. 2021

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Background: Although many works have supported the utility of PET radiomics, several authors have raised concerns over the robustness and replicability of the results. This study aimed to perform a systematic review on the topic of PET radiomics and the used methodologies. Methods: PubMed was searched up to 15 October 2020. Original research articles based on human data specifying at least one tumor type and PET image were included, excluding those that apply only first-order statistics and those including fewer than 20 patients. Each publication, cancer type, objective and several methodological parameters (number of patients and features, validation approach, among other things) were extracted. Results: A total of 290 studies were included. Lung (28%) and head and neck (24%) were the most studied cancers. The most common objective was prognosis/treatment response (46%), followed by diagnosis/staging (21%), tumor characterization (18%) and technical evaluations (15%). The average number of patients included was 114 (median = 71; range 20–1419), and the average number of high-order features calculated per study was 31 (median = 26, range 1–286). Conclusions: PET radiomics is a promising field, but the number of patients in most publications is insufficient, and very few papers perform in-depth validations. The role of standardization initiatives will be crucial in the upcoming years.

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Biological correlates of tumor perfusion and its heterogeneity in newly diagnosed breast cancer using dynamic first-pass 18F-FDG PET/CT

Cited by 13 publications

References 46 publications

Overexpression of METTL3 associated with the metabolic status on ¹⁸F-FDG PET/CT in patients with Esophageal Carcinoma

Overexpression of METTL3 associated with the metabolic status on ¹⁸F-FDG PET/CT in patients with Esophageal Carcinoma

Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization

A Systematic Review of PET Textural Analysis and Radiomics in Cancer

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Biological correlates of tumor perfusion and its heterogeneity in newly diagnosed breast cancer using dynamic first-pass 18F-FDG PET/CT

Cited by 13 publications

References 46 publications

Overexpression of METTL3 associated with the metabolic status on 18F-FDG PET/CT in patients with Esophageal Carcinoma

Overexpression of METTL3 associated with the metabolic status on 18F-FDG PET/CT in patients with Esophageal Carcinoma

Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization

A Systematic Review of PET Textural Analysis and Radiomics in Cancer

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Product

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Overexpression of METTL3 associated with the metabolic status on ¹⁸F-FDG PET/CT in patients with Esophageal Carcinoma

Overexpression of METTL3 associated with the metabolic status on ¹⁸F-FDG PET/CT in patients with Esophageal Carcinoma