Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization

Abstract

Based on the study of recent scientific literature devoted to neovascularization and angiogenesis in malignant neoplasms, it was concluded that there are many publications on each of the problems of tumor angiogenesis and vascularization. The formation of blood vessels in a tumor and certain aspects of the prognostic value of the severity of vascularization in almost all forms of cancer are considered. Special attention is paid to the peculiarities of angiogenesis in tumors of the female reproductive system. A large number of vessels in the tumor often indicates a poor prognosis. The influence of various factors on the initiation of angiogenesis and the process itself, as well as the possibility of suppressing such signals to slow down the formation of blood vessels and thus the development of the tumor are widely studied. The results of pharmacological suppression of tumor vessel formation demonstrate a good clinical outcome but one accompanied by a large number of severe adverse side effects. Such a significant amount of studies on each of the problems of tumor vascularization indicates the increasing importance of this area of oncology. At the same time, only a very small number of works are devoted to the study of the differences in angiogenesis and number of vessels between different parts of the tumor, as well as between the primary tumor node and its metastases. The refinement of the results is still to be done. It was noted that the expression of proangiogenic factors in metastases is usually higher than in the source of metastasis, and the expression in lymphogenous metastases is higher than in hematogenous ones.

Promotion of non-small cell lung cancer tumor growth by FHL2 via inducing angiogenesis and vascular permeability

“…Angiogenesis is a complex process, tightly regulated by certain growth factors, receptors, and humoral factors ( 30 ). Among all the identified angiogenic pathways, the most critical one appears to be VEGFA/VEGFR signaling pathway, which is the main driver of vascular permeability via the activation of VEGFR2 ( 31 ).…”

Analysis of Risk Factors for Distant Metastasis of Pancreatic Ductal Adenocarcinoma without Regional Lymph Node Metastasis and a Nomogram Prediction Model for Survival

“…Blood metastasis is also an important pathway that leads to distant metastasis. Tumor cells can directly metastasize to distant organs through the blood without passing through the lymphatic circulation [ 19 , 20 ]. Ueberroth al.…”

An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models

“…Microfluidic technologies provide a unique benefit for multicell co-culture by facilitating heterotypic interactions and paracrine signaling that are impossible in traditional environments. [10,41,95,133,134] The co-culture of ECs and mural cells has shown the development of an adult vascular network and active angiogenic sprouting. The factors and parameters significantly improve the precision and reliability of VToC.…”