Biological Compound Capping of Silver Nanoparticle with the Seed Extracts of Blackcumin (Nigella sativa): A Potential Antibacterial, Antidiabetic, Anti-inflammatory, and Antioxidant

Vijayakumar, Sekar; Divya, Mani; Vaseeharan, Baskaralingam; Chen, Jingdi; Biruntha, Muniyandi; Silva, Luciano; Durán-Lara, Esteban F.; Shreema, Krishnan; Ranjan, Shivendu; Dasgupta, Nandita

doi:10.1007/s10904-020-01713-4

Cited by 44 publications

(20 citation statements)

References 57 publications

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“…The release of lysosomal enzymes may cause the damaging of bio macromolecules and lipid peroxidation of membranes. [54] In the current study, both T-AgNPs and Tamarix extract exhibited potential inhibitory property against heat-induced protein denaturation and proteinase action. In addition, T-AgNPs stabilized the erythrocyte membrane in a concentration dependent manner.…”

Section: Discussionmentioning

confidence: 59%

Biosynthesis of silver nanoparticles using Tamarix articulata leaf extract: an effective approach for attenuation of oxidative stress mediated diseases

Anwar

Almatroodi

Almatroudi

et al. 2021

International Journal of Food Properties

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To investigate the biosynthesis of silver nanoparticles (T-AgNPs) using leaf extract of Tamarix articulata and their possible role in attenuation of oxidative stress mediated human diseases. T-AgNPs were characterized by several biophysical techniques. Various health beneficial activities were also investigated. The synthesized T-AgNPs showed an absorption peak at 413 nm on UV-Visible spectroscopy indicating the surface plasmon resonance of the nanoparticles. TEM analysis clearly showed that particles were spherical with an average size of about 25 nm. SEM image analysis confirmed the spherical shape of T-AgNPs. T-AgNPs (600 µg/ml) showed effective DPPH scavenging (68.23%), ferric reducing (68.23%), and hydrogen peroxide reducing (70.09%) activities. Besides, T-AgNPs at 600 µg/ml, also showed strong anti-glycating, and AGEs formation inhibitory activities as indicated by reduced browning intensity (51.62%), aggregation index (48.86%), and cross amyloid structures (53.62%) as compared to positive controls (100%). A 600 µg/ml of T-AgNPs was found to have potent in vitro anti-inflammatory activity as revealed by albumin denaturation inhibition (73.19%), protease activity inhibition (70.196%), membrane stability against heat (74.16%), and hyposaline (72.98%) induced hemolysis as compared to controls. Altogether, these findings confirm that T-AgNPs can be promising candidates for the development of antioxidant, anti-inflammatory, membrane stabilizing, antiglycating and AGEs inhibitory agents.

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Section: Discussionmentioning

confidence: 59%

Biosynthesis of silver nanoparticles using Tamarix articulata leaf extract: an effective approach for attenuation of oxidative stress mediated diseases

Anwar

Almatroodi

Almatroudi

et al. 2021

International Journal of Food Properties

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“…This inhibitory zone was comparable to chlorphenicol (0.66 mm). The exact antibacterial mechanism of AgNPs is unknown, but it seems they interact with the sulfhydryl group of proteins and DNA bases to inhibit respiration and replication in bacteria [41][42][43][44]. The antibacterial effect of Bio-AgNPs against S. aureus and E. coli was higher than that of Chem-AgNPs.…”

Section: Figure 4 Near Herementioning

confidence: 99%

Fabrication of antibacterial PVA/Bentonite/Ag Composite Nanofibers with Bio-AgNPs synthesized with Fusarium sporotrichioides

Mokhtari-Hooseini

Hatamian-Zarmi

Mahdizadeh

et al. 2022

Preprint

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Nowadays, membranes and filters made of nanofibers are extensively considered in various fields, such as medicine, water purification, etc. Using an environmentally-friendly method, this study fabricated a nanofiber-based on PVA, bentonite, and silver nanoparticles (AgNPs) with good mechanical strength. Due to conventional AgNPs synthesis methods' toxicity, AgNPs were synthesized by Fusarium sporotrichioides. The MGYP culture medium and the AgNO3 12 M were optimal for Bio-AgNPs synthesis. Bio-AgNPs particle size and zeta potentials were 58 nm and -16.8 mV, respectively. The growth inhibition zone of Bio-AgNPs in E. coli and S. aureus was 0.53 and 0.80 mm, respectively and comparable with chloramphenicol. Then, the optimized Bio-AgNPs and a sample with chemical synthesis AgNPs were used to prepare the PVA/nano-Bentonite/nano-Ag (PVA/NB/AgNPs) nanofiber. The presence of silver in the nanofibers was confirmed through EDX and XRD methods. The diameter of nanofibers was 230 nm. The antibacterial activity of PVA/NB/Bio-AgNPs nanofibers was significantly better against both gram-positive and gram-negative bacteria compared to PVA/NB/Chem-AgNPs nanofibers. The produced membrane is suitable for water treatment, food packaging, and wound dressing because of its good thermal, mechanical, and antibacterial properties.

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“…Also, the consumption of 5 g/day of black cumin for six months caused a decrease in glycated hemoglobin [ 98 ]. On the other hand, the nanoparticles formed from silver nitrates showed inhibitory activity on both α-amylase enzymes and α-glucosidase which was higher than that obtained by aqueous extract or even by acarbose used as a control [ 99 ]. The hydroalcoholic extract (50%) was tested on rats with streptozotocin-induced diabetes.…”

Section: Pharmacological Properties Of Nigella Sativamentioning

confidence: 99%

Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)

et al. 2021

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Medicinal and aromatic plants are mainly characterized by the presence of different bioactive compounds which exhibit various therapeutic activities. In order to investigate the different pharmacological properties of different Nigella sativa extracts, a multitude of research articles published in the period between 2019 and 2021 were obtained from different databases (Scopus, Science Direct, PubMed, and Web of Science), and then explored and analyzed. The analysis of the collected articles allows us to classify the phytochemicals and the pharmacological activities through their underlying molecular mechanisms, as well as to explore the pharmacological activities exhibited by several identified compounds in Nigella sativa which allow a better understanding, and better elucidation, of the bioactive compounds responsible for the pharmacological effects. Also shown are the existence of other bioactive compounds that are still unexplored and could be of great interest. This review could be taken as a guide for future studies in the field.

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Biological Compound Capping of Silver Nanoparticle with the Seed Extracts of Blackcumin (Nigella sativa): A Potential Antibacterial, Antidiabetic, Anti-inflammatory, and Antioxidant

Cited by 44 publications

References 57 publications

Biosynthesis of silver nanoparticles using Tamarix articulata leaf extract: an effective approach for attenuation of oxidative stress mediated diseases

Biosynthesis of silver nanoparticles using Tamarix articulata leaf extract: an effective approach for attenuation of oxidative stress mediated diseases

Fabrication of antibacterial PVA/Bentonite/Ag Composite Nanofibers with Bio-AgNPs synthesized with Fusarium sporotrichioides

Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)

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