Biological compatibility, thermal and in vitro simulated degradation for poly(p‐dioxanone)/poly(lactide‐co‐glycolide)/poly(ethylene succinate‐co‐glycolide)

Abstract

Bio‐absorbable polymers are widely desired to be applied and used as biomaterials for surgery hemostatic and medical tissue engineering devices. Ring‐opening copolymerization reaction was applied to synthesize poly(ethylene succinate‐co‐glycolide) (PES‐b‐PGA). Stannous octoate was used as a catalyst whereas poly(ethylene succinate) was used as a macro‐initiator to react with glycolide. PES‐b‐PGA was then used as a compatibilizer to prepare the blend biomaterial of PPDO/PLGA/PES‐b‐PGA by melt blending poly(p‐dioxanone) (PPDO) with poly(lactide‐co‐glycolide) (PLGA). This would enhance the interactions of the inter‐molecular chains and intra‐molecular segments thus improving the compatibility. To obtain the biomaterial of PPDO/PLGA/PES‐b‐PGA with a regulated and controlled degradation and/or hydrolysis period, various ratios of PPDO, PLGA, and PES‐b‐PGA was blended. Behaviors of the thermal and in vitro simulated degradation, biological compatibility, cytotoxicity and subcutaneous implantation of PPDO/PLGA/PES‐b‐PGA were investigated. The results show that the in vitro hydrolytic degradation cycle is consistent with the wound healing time and that the biomaterial has slight cytotoxicity and it will do good to the cell proliferation, with 1 grade of cytotoxicity and the relative growth rate being the range from 92.5% to 96.2%. The implantation of the biomaterial into the rabbits' ears will not adversely affect the wound healing and the tissues surrounding the implanted sites. Therefore, the biomaterial has good biocompatibility and potential applications in medical tissue engineering devices.

Implantable Immunosuppressant Delivery to Prevent Rejection in Transplantation

“…The recent use of polymeric biomaterials in transplantation studies, such as PLGA, PCL, and PEG, showed good biocompatibility, including cellular response, cell adhesion, and hemocompatibility [95,96]. Biocompatibility may be further enhanced by modification or addition of other polymeric materials [97][98][99][100]. For those nanoparticles, the ISO standard 1099-22 test that is dedicated to assessing the impact of shape, size, surface charge and function, dispersion state, matrix composition, attached protein formation on cell viability, and endocytosis process have been described [101,102].…”