Biological compatibility of some types of endodontic calcium hydroxide and glass ionomer cements

Valera, Márcia Carneiro; Leonardo, Mário Roberto; Consolaro, Alberto; Matuda, Fábio da Silva

doi:10.1590/s1678-77572004000400008

Cited by 8 publications

(4 citation statements)

References 14 publications

(7 reference statements)

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“…There was no evidence of calcification or necrosis. These findings were in accordance with Valera et al (2004), Yaltirik et al (2004) and de Morais et al (2006). This mild reaction may be due surgical trauma during the implantation of tube.…”

Section: Discussionsupporting

confidence: 88%

Biocompatibility and osteogenic potential of the new bioceramic endodontic material “EndoSeal MTA”

Rehan

2019

Egyptian Dental Journal

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Aim:This study was conducted to analyze the biocompatibility of EndoSeal MTA® in rat subcutaneous tissue and to detect the osteogenic effect of this material. Methods:The biocompatibility was assessed using the subcutaneous implantation technique. Thirty male albino rats were the subjects used during current research. Animal subjects were anaesthetized, shaved in two areas of the dorsal surface of both of the lower limbs and subcutaneous pockets were made to accommodate the material, which was placed in a polyethylene tubes. Empty polyethylene tubes were used as control. Fifteen animals were sacrificed at each observation period (1 month and 3 months implantation). A wide excision of the tissues surrounding the implant was taken, managed and histo-stained with Haematoxylin and Eosin stain for histopathological evaluation of the inflammatory and vascular responses. The Von Kossa histochemical stain was used for demonstration of the mineralized structures. The stained sections were examined using light microscopy. Quantitative analysis of the inflammatory cells was performed using an image analyzer computer system.Results: After one month of tube implantation, mild chronic inflammatory cell infiltration, loosely organized collagen fibers and few slightly dilated blood vessels were observed in the control group. In the experimental group, the inflammatory reaction ranged from mild to moderate. The inflammatory reaction significantly subsided with time in both groups. The difference between the control and experimental group regarding the total number of inflammatory cells was not statistically significant in the both observation periods. No evidence of tissue necrosis was found in the control or experimental groups throughout the experiment. Conclusions:It could be concluded that EndoSeal MTA® is well tolerated by the subcutaneous connective tissues of rat. The study showed osteogenic potential of EndoSeal MTA®.

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Section: Discussionsupporting

confidence: 88%

Biocompatibility and osteogenic potential of the new bioceramic endodontic material “EndoSeal MTA”

Rehan

2019

Egyptian Dental Journal

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“…The implementation methodology of polyethylene tubes in the connective tissue of mice used in this study was based on Torneck (1966) experiments, which demonstrated the acceptability of this material by the subcutaneous connective tissue of animals, as well as, since it is a controlled method with few variables and low cost (Garcia et al, 2008;Valera et al, 2004). Besides, polyethylene tubes mimic the conditions of the root canal, since only the final portion of the tube, corresponding to the root apex, the test material will contact the tissue and the opposite side sealed with biocompatible material will serve as control (Zmener et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

Effect of Laser Therapy in Inflamed Tissue by Medications Based on Iodoform Laser Therapy in Inflamed Tissue

Tomaz

Farias

Piva

et al. 2013

American Journal of Applied Sciences

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This study aimed to evaluate the inflammatory response of the subcutaneous tissue of twenty rats when the use of iodoform with different drugs or not associated with laser photobiomodulation. In the dorsum of rats were introduced into tubes containing: Iodoform and calcium hydroxide (Ca (OH)₂); Iodoform and Ca(OH)₂, associated with Laser; Iodoform and Otosporin; Iodoform and Otosporin, associated with Laser. The animals were euthanized eight and fifteen days after surgery, the parts were removed and processed in the laboratory with staining with Hematoxylin-Eosin (HE) and Picrosirius Red. The statistical significances of the inflammatory infiltrate and quantification of collagen fibers were measured by ANOVA-Tukey test. The association between Ca (OH)₂ and iodoform with determined the best response in the host tissues. The low level laser therapy was effective in modulating the inflammatory response and deposit collagen fibers

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“…Studies on tissue reactions to implanted test specimens into soft and bone tissues in experimental animals (rats, guinea pigs) have documented a differential response to various endodontic materials . ZnO–eugenol‐ and resin‐based materials typically cause a pronounced initial inflammatory reaction, which diminishes with time especially for the epoxy‐based products .…”

Section: Animal Experimentsmentioning

confidence: 99%

Endodontic filling materials

Ørstavik¹

2014

Endodontic Topics

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The principal function of root filling materials is to prevent invasion of bacteria and infection of the root canal system after completed endodontic treatment. This is accomplished by the formation of a tight, permanent seal with the surrounding tooth structure, leaving no space for invasion of or colonization by bacteria. The materials can also have a direct antibacterial effect and kill the microbes when in contact with them. Materials applied onto larger areas of connective tissue, i.e. for retrograde root fillings or perforation repair, should also allow or stimulate complete repair or regeneration. Ideally, the selection of materials for various applications in endodontics should be based on clinical, scientifically valid data. However, most current endodontic practices and choice of materials are based on a convoluted history where data of varying relevance and validity is mixed with experts’ stated opinions and manufacturers’ advertising. In this review, the chemical, physical, and biological properties of different root filling materials are discussed together with their handling characteristics and recommended use in the clinic. Emphasis is placed on evidence generated from clinical practice and research.

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Biological compatibility of some types of endodontic calcium hydroxide and glass ionomer cements

Cited by 8 publications

References 14 publications

Biocompatibility and osteogenic potential of the new bioceramic endodontic material “EndoSeal MTA”

Biocompatibility and osteogenic potential of the new bioceramic endodontic material “EndoSeal MTA”

Effect of Laser Therapy in Inflamed Tissue by Medications Based on Iodoform Laser Therapy in Inflamed Tissue

Endodontic filling materials

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