Biological and thermodynamic stabilization of lipid-based delivery systems through natural biopolymers; controlled release and molecular dynamics simulations

Laein, Sara Safaeian; Katouzian, Iman; Mozafari, M. R.; Farnudiyan‐Habibi, Amir; Akbarbaglu, Zahra; Shadan, Mohammad Reza; Sarabandi, Khashayar

doi:10.1080/10408398.2023.2191281

Cited by 7 publications

(2 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the multitude of mentioned advantages, challenges such as low bioavailability, instability, hydrophobicity, bitter taste, incompatibility, and reaction with other food compounds (e.g., metal ions) are considered among the factors limiting the use of bioactive peptides in the fortification and production of functional foods (McClements 2015 ). A method to reduce these disadvantages is the stabilization of peptides using different lipid-based nanodelivery systems include solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), nanoemulsions, lipid-polymer hybrid nanoparticles and nanoliposomes (Safaeian Laein et al 2023 ).…”

Section: Introductionmentioning

confidence: 99%

“…SLNs are composed of solid lipids or in combination with surfactants that allow long-term release, less leakage and more stability of the system (Shtay et al 2018 ). NLCs are composed of a liquid lipid mixed with solid lipids, furthermore, due to the disorganized structure of solid and liquid lipids this carrier can accommodate several compounds and enable a controlled release trend (Safaeian Laein et al 2023 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protection of navy-bean bioactive peptides within nanoliposomes: morphological, structural and biological changes

Namdar,

Roufegarinejad,

Alizadeh

et al. 2023

Bioresour. Bioprocess.

Self Cite

View full text Add to dashboard Cite

This study aimed to produce bioactive peptides from navy-bean protein with alcalase and pepsin enzymes (30–300 min) and to load them into a nanoliposome system to stabilize and improve their bioavailability. The degree of hydrolysis and biological activities (scavenging of DPPH, OH, and ABTS free radicals, reducing power, and chelating metal ions) of navy-bean protein were affected by the type of enzyme and hydrolysis time. The average particle size (83–116 nm), PDI (0.23–0.39), zeta potential (− 13 to − 20 mV), and encapsulation efficiency (80–91%) of nanoliposomes were influenced by the type and charge of peptides. The storage temperature and the type of loaded peptide greatly affected the physical stability of nanocarriers and maintaining EE during storage. The FTIR results suggested the effect of enzymatic hydrolysis on the secondary structures of protein and the effective placement of peptides inside polar-regions and the phospholipid monolayer membrane. SEM images showed relatively uniform-sized particles with irregular structures, which confirmed the results of DLS. The antioxidant activity of primary peptides affected the free radical scavenging of loaded nanoliposomes. Liposomes loaded with navy-bean peptides can be used as a health-giving formula in enriching all kinds of drinks, desserts, confectionery products, etc. Graphical Abstract

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%