Biological and protein‐binding studies of newly synthesized polymer–cobalt(III) complexes

Vignesh, Gopalaswamy; Pradeep, I.; Arunachalam, S.; Vignesh, S.; Rathinam, Arthur James; Renganathan, Arun; Premkumar, Kumpati

doi:10.1002/bio.2992

Cited by 14 publications

(8 citation statements)

References 53 publications

(45 reference statements)

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“…Currently, the development of metal complexes with nonplatinum central atoms including ruthenium [11], gold [12], silver [13], copper [14], zinc [15], Manganese [16], nickel [17], iridium [18] and cobalt [19] has been one of the hottest emerging areas of anticancer drug research. Among these, carbonyl cobalt complex has strong properties of cancer prevention including tumour growth/metastasis suppression [20], antiproliferative [21], DNA cleavage [22], apoptotic induction [23] and autophagy [8], which was more active than cisplatin on the human breast tumour cell lines (MCF-7 and MDA-MB-231) [24,25] and ovarian cancer cells (SKOV3/ DDP) [26]. With the concept of carbonyl metal CO-releasing molecules (CORMs) appearing, the anti-inflammatory effects were found through liberating CO to inhibit nitrite content [27].…”

Section: Introductionmentioning

confidence: 99%

Co-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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To evaluate the safety and efficacy of novel cobalt complex with sulindac (Co-SLD), the zebrafish and oral squamous cell carcinoma CAL27 were investigated in the present study. The developmental toxicity of Co-SLD ranging from 5 to 20 lM was determined by exposure to 3-144-h post-fertilization (hpf) zebrafish. Our data showed that Co-SLD did not cause to the appreciable toxicity at low concentration (5 and 10 lM). A remarkable toxicity was observed at high concentration (20 lM), including increased mortality and malformation, delayed hatchability, reduced heart rate as well as suppressed behaviour. With regard to the antitumor activity of Co-SLD, inhibited cell growth and migration capability were outstandingly observed in oral squamous cell carcinoma treated with 10 and 20 lM Co-SLD, which could be mainly attributed to the Co-SLD-elicited mitochondrial damage as marked by the depression of mitochondrial membrane potential, ROS accumulation and ATP depletion. Furthermore, administration of 10 lM Co-SLD was an optimal concentration not only to avoid the normal tissue toxicity, but also to enhance the killing of cancer cells via disrupting mitochondrial dysfunction. Taken together the above results demonstrated the desirable response of oral squamous cell carcinoma to Co-SLD. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Co-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function

Zhang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…Optical response was recorded under UV-Vis spectroscopy in relation to increase in time duration [14]. The observation of brown and red colours is a characteristic feature for the surface plasmon resonance (SPR) band due to the formation of different sizes of silver nanoparticles in the respective solutions [15]. The transverse plasmon resonance absorption peak appeared at 540 nm is slightly shifted to shorter wavelength along with increase in intensity.…”

Section: Uv-vis Spectrum Analysismentioning

confidence: 99%

Bioreduction of silver nanoparticles characterizations and their antimicrobial activity

Gowthami¹,

Kanna²,

sankari³

et al. 2017

Int J of Adv in Sci Res

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In this investigation we report the bioreduction of silver nitrate to silver nanoparticles using the leaves aqueous extract of Alangium lamarckii. The silver nanoparticles were characterized by UV-vis spectrophotometer, scanning electron microscope (SEM), DLS-Size and zeta potential analysis showed that the synthesized silver nanoparticles are varied from 60 -70 nm and have the spherical shape. Further the prospect of protein as a stabilizing material in silver nanoparticles is shown by FTIR analysis and the XRD examination confirms monocrystalline phase of silver with FCC crystal structure. The antimicrobial activity of Ag nanoparticles was investigated against some pathogens. In these assessments, silver nanoparticles (AgNP) can stop microbial growth and even kill microbes, from now confirmed their antimicrobial importance.

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“…The size of spherical shaped silver nanoparticles is ranging from 5 to 20 nm, as evident by SEM. With increasing intensity of extract during the period of incubation, silver nanoparticles showed gradual change in colour of the extracts to yellowish brown with callus extract of the salt marsh plant, Sesuvium portulacastrum L. [14]. …”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Herbal derived nanomedicines against for some human pathogens

Amirthavarshini¹,

Kanna²,

Moin

et al. 2017

Int J of Adv in Sci Res

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The aim of this study was to achieve the silver nanocrystals for therapeutic values. The Aristolochia bractiata leaves extract as a reducing substance for the biosynthesis of silver nanoparticles. UV-Vis spectra analysis, Dynamic Light Scattering Particle size analyzer, X-ray Diffraction method and Scanning electron microscopy (SEM) with X-ray spectroscopy (EDS) have been employed to characterize and confirmed the nanocrystal formation. In antimicrobial activity, the silver nanoparticles were most against some human pathogens. In bacteria, the test sample was most effective against Salmonella typhimurium NCIM 2501 (B5) while smaller effect was noticed from Micrococcus luteus NCIM 2871 (B4). In fungi, which was effective against Trichophyton rubrum MTCC 3272 (F4) whereas smaller effect was observed in Cryptococcus sp. MTCC 7076 (F2). All the microbial strains depict higher sensitivity to the higher concentration (30μL) for the test sample when compared to the positive control except few bacterial strains.

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Biological and protein‐binding studies of newly synthesized polymer–cobalt(III) complexes

Cited by 14 publications

References 53 publications

Co-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function

Co-SLD suppressed the growth of oral squamous cell carcinoma via disrupting mitochondrial function

Bioreduction of silver nanoparticles characterizations and their antimicrobial activity

Herbal derived nanomedicines against for some human pathogens

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