Biological and Pharmacological Effects of Gamma-oryzanol: An Updated Review of the Molecular Mechanisms

Abstract

Background: Gamma-oryzanol (γ-oryzanol) is one of the rice bran oil (RBO) compounds, known as a principal food source throughout the world. In recent numerous experimental studies, γ-oryzanol has been revealed to have several useful pharmacological properties such as antioxidant, anti-inflammatory, anticancer, anti-diabetic, ameliorating menopausal unpleasant symptoms, cholesterol-lowering, plasma lipid pattern improving, etc. Methods: In this study we reviewed the scientific literature published up until 2020, which have evaluated the biological and pharmacological activity of gamma-oryzanol. This review summarizes the published data found in PubMed, Science Direct and Scopus. Results & Conclusion: The present review attempts to summarize the most related articles about the pharmacologic and therapeutic potential from recent studies on γ-oryzanol to gain insights for design further studies to achieve new evidence which confirm observed effects.

Potential Antitumor Effect of Functional Yogurts Formulated with Prebiotics from Cereals and a Consortium of Probiotic Bacteria

“…This process leads to the sequential activation of Caspase-3, -8, and -9. The sequential activation of these types of proteins triggers the execution process of programmed cell death (apoptosis) [ 72 , 73 ]. Regarding probiotics from the Bifidum genus, the study we carried out showed that under the influence of Bifidobacterium bifidum metabolites, the inhibition process of tumor cells of type Caco-2-HTB-37 is dominated by early apoptosis (tumor cells in early apoptosis: 58%) ( Figure 1 c) and by late apoptosis (tumor cells in late apoptosis: 41%) in the case of HTB-38-type tumor cells ( Figure 1 b).…”

Efficacy, safety and mechanism of Honghua Xiaoyao Pill in the treatment of peri-menopausal syndrome: A study protocol for a randomized controlled trial

“…The mechanism study shows that oryzanol can increase the release of catecholamine related relatives in limbic system through the blood-brain barrier, which may be related to the improvement of stress ( Fujii et al, 2018 ). In addition, some studies have found that oryzanol also has anti-inflammatory and antioxidant effects ( Minatel et al, 2016 ; Ramazani et al, 2021 ). These effects are similar to the pharmacological effects of HHXYP, so we choose oryzanol, a recommended supplement in improving PMPS, as the control drug.…”

The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasome in Liver Disorders

“…This phenomenon is called hepatic ischemia–reperfusion injury (HIRI) [ 70 , 71 ]. γ-Oryzanol (ORY) is one of the rice bran oil (RBO) compounds, which is known as the main food source in the world [ 72 ]. ORY has been reported to have anti-diabetic, anti-hyperlipidemic, anti-carcinogenic, anti-inflammatory, anti-ulcerogenic, and antioxidant effects [ 73 , 74 ].…”