Biological and genetic landscape of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL)

Rondón-Lagos, Milena; Rangel, Nelson; Camargo-Villalba, Gloria Eugenia; Forero-Castro, Maribel

doi:10.1016/j.ejso.2020.10.029

Cited by 17 publications

(22 citation statements)

References 75 publications

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“…In addition, macrophages also cause IL-6 ( D ), which leads to Th17 cell mutation, and IL-6 also is activated through activation of the JAK/STAT signaling pathway ( E ). Reproduced with permission from [ 169 ].…”

Section: Figurementioning

confidence: 99%

Anaplastic Large Cell Lymphoma: Molecular Pathogenesis and Treatment

Zhang

Chien

Nam

et al. 2022

Cancers

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Anaplastic large cell lymphoma (ALCL) is an uncommon type of non-Hodgkin’s lymphoma (NHL), as well as one of the subtypes of T cell lymphoma, accounting for 1 to 3% of non-Hodgkin’s lymphomas and around 15% of T cell lymphomas. In 2016, the World Health Organization (WHO) classified anaplastic large cell lymphoma into four categories: ALK-positive ALCL (ALK+ALCL), ALK-negative ALCL (ALK−ALCL), primary cutaneous ALCL (pcALCL), and breast-implant-associated ALCL (BIA-ALCL), respectively. Clinical symptoms, gene changes, prognoses, and therapy differ among the four types. Large lymphoid cells with copious cytoplasm and pleomorphic characteristics with horseshoe-shaped or reniform nuclei, for example, are found in both ALK+ and ALK−ALCL. However, their epidemiology and pathogenetic origins are distinct. BIA-ALCL is currently recognized as a new provisional entity, which is a noninvasive disease with favorable results. In this review, we focus on molecular pathogenesis and management of anaplastic large cell lymphoma.

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Section: Figurementioning

confidence: 99%

Anaplastic Large Cell Lymphoma: Molecular Pathogenesis and Treatment

Zhang

Chien

Nam

et al. 2022

Cancers

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“…The new free-hand configuration led the genus Homo to develop a wider range of movements in the upper limb. 3 Genetically, muscle fibers are present in a greater amount in male muscles compared to that in female muscles. 4 Consequently, men do have greater physical power compared with women, but velocity of contraction is usually faster in women.…”

Section: Disclosurementioning

confidence: 99%

Gynecomastia Treatment through Open Resection and Pectoral High-Definition Liposculpture

Danker

Yarholar

2022

Plastic &Amp; Reconstructive Surgery

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Plastic and Reconstructive Surgery • November 2022 leading a team too much like a man, and not enough like a woman, because of my tone.This has become a tired story. We are tired of it, too. We are tired of wasting anger and frustration on individuals who are not solely to blame for these stereotypes because the issue is bigger than a few isolated beings. It is a systemic issue, like a mycorrhizal network, an underground network of threadlike fungi that connects the roots of neighboring plants to each other and that allows for the transfer of information and nutrients. It is a deep-seated issue that cannot be addressed easily or individually. So, we force ourselves to get "used" to it. We talk ourselves down, we roll our eyes internally, and we try not to let it affect the relationships we are building with referring providers or with patients and their families. It hurts every time we let it go, but we resign ourselves to the fact that sometimes it's for the best. Unconscious bias is a powerful and dangerous force. We have seen how deadly it can be, with the death of George Floyd and so many before and after him, with the reckoning that our society is undergoing with the Black Lives Matter movement. Its recognition by the offender requires effort, self-awareness, and mindfulness. It takes even more energy to reverse the practice, the habit, the way of interacting with others. While women continue to interface with the spectrum of effort to noneffort toward gender equality, we understand that, in general, things are improving. Women outnumber men in medical schools. Female representation and leadership in plastic surgery is growing.The sentence that appeared in the May 2021 article was authored by three individuals and then made it past at least three reviewers and a number of other content editors. This does not represent a case of unconscious bias or microaggression. It is a blatant offense to women. It is both surprising and disappointing that it was published in our field's leading journal. We write this with a thoughtful tone of anger, despite the hesitation and consideration of softening the air. However, this is not one of those instances that calls for quiet resignation. We need to do better.

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“…Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon non-Hodgkin's T-cell lymphoma [45,46], characterized by a monoclonal population of CD30+ large anaplastic cells, negative anaplastic lymphoma kinase and variable expression of lymphocyte T and EMA markers [28,47]. The first case of BIA-ALCL described in 1997 by Keech and Creech was reported in a patient with saline implants [48].…”

Section: Breast Implant-associated Anaplastic Large Cell Lymphomamentioning

confidence: 99%

Current Challenges in Breast Implantation

et al. 2021

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Breast implantation (BI) is the most common plastic surgery worldwide performed among women. Generally, BI is performed both in aesthetic and oncoplastic procedures. Recently, the prevalence of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) or breast implant illness (BII) has aroused concerns. As a result, several countries, like Australia, Korea or the United Kingdom, introduced national registries dedicated to the safety and quality of BI surgeries. This narrative review aimed to focus on the clinical challenges, management and the current state of knowledge of BI. Both short and long-term outcomes of BI are determined by various alternatives and differences, which surgeons must consider during the planning and performing breast augmentation along with further complications or risk of reoperation. Proper preoperative decisions and aspects of surgical technique emerged to be equally important. The number of performed breast reconstructions is increasing, providing the finest aesthetic results and improving patient’s quality of life. Choice of prosthesis varies according to individual preferences and anatomical variables. A newly diagnosed cases of BIA-ALCL with lacking data on prevention, diagnosis, and treatment are placing it as a compelling medical challenge. Similarly, BII remains one of the most controversial subjects in reconstructive breast surgery due to unspecified diagnostic procedures, and recommendations.

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Biological and genetic landscape of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL)

Cited by 17 publications

References 75 publications

Anaplastic Large Cell Lymphoma: Molecular Pathogenesis and Treatment

Anaplastic Large Cell Lymphoma: Molecular Pathogenesis and Treatment

Gynecomastia Treatment through Open Resection and Pectoral High-Definition Liposculpture

Current Challenges in Breast Implantation

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