“…There is a secular trend in the mean age at menarche with a steady decline over the last several decades (Hwang et al, 2003;Herman-Giddens, 2007). Age at menarche has important implications in female fertility (McKibben and Poston, 2003;Pascual et al, 2005) and, furthermore, it may serve as an indicator of possible health complications in later life. Earlier menarche is associated with an increased risk of some diseases, such as breast cancer (Schatzkin et al, 1987;Peeters et al, 1995), gynecological cancers (Marshall et al, 1998;Fujita et al, 2008) and various cardiovascular diseases (Cooper et al, 1999;Lakshman et al, 2009).…”