Biological activity of the derivatives of 1,2,4-triazole

Abstract

The rapid development of modern medicine and pharmacy leads to an increase in synthetic drugs. Thus, in the professional literature says that one of the perspective directions are searching for new biologically active compounds including heterocyclic systems and the introduction of the latest in medical, pharmaceutical or veterinary practice.
 It is known that heterocyclic ring system 1,2,4-triazole moiety is promising for the synthesis of new active ingredients with various kinds of pharmacological actions.
 The aim of the study was the analysis of literature and patent sources over the past 10 years and the generalization of the results for certain types of biological activity of 1,2,4-triazole.
 Results of literary analysis show a wide range of biological activity of 1,2,4-triazole-3-tion. The data determine the relevance of further research of derivatives of 1,2,4-triazole in the actoprotective, antimicrobial, antifungal, antihypoxic, hypoglycemic, analgesic, antiinflammatory and others activity in order to find new highly effective in terms of biological substances that can form the basis of new medicines.

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

“…Separately to the ability to proliferate, 1,2,4-triazole derivatives are able to have a cytoprotective effect. Cytoprotection is manifested in antioxidant [41][42][43][44][45], antihypoxic [46][47][48][49][50], hepatoprotective [51][52][53][54][55], neuroprotective [56][57][58][59][60] action. In particular, scientists [60] conducted an extensive review of 64 compounds that can find their application in the treatment of Alzheimer's disease.…”

“…7). In the analyzed works [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60], 40 potential antioxidants were identified, among which the authors separately Note 4 molecules; 44 compounds with antihypoxic activity were identified, of which 5 are recommended for further study. 106 potential neuroprotectors were identified, of which 7 attract special attention of scientists.…”

Synthesis of Schiff Bases of 4-Amino-5- (2-Hydroxyphenyl)-4H- 1,2,4-Triazole-3-Thiol as Potent Antimicrobial Agents

“…The name 'Triazole' was given to the five-membered diunsaturated ring structure composed of three nitrogen atoms and two carbon atoms at non-adjacent positions having molecular formula C 2 H 3 N 3 (Bladin 1885). Out of the isomeric pair, 1,2,4-triazole has a wide range of biological targets (Kravchenko, Panasenko & Knysh 2018).1,2,4-Triazole nucleus and its derivatives represent one of the most biologically active class of compounds that are associated with diverse pharmacological activities such…”