Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

Yurii, Sameliuk; Kaplaushenko, A. G.; Nedorezaniuk, Natalia; OSTRETSOVA, Liusine; DİAKOVA, Feodosiia; Gutyj, B. V.

doi:10.52794/hujpharm.1019625

Cited by 11 publications

(9 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies were also conducted on the ability of liposomes to detoxicate. Over a half of them enter the liver, 1/6 enter the spleen, where they become occupied by hepatocytes and macrophages (Khariv et al, 2017;Abbasi et al, 2022;Karpenko et al, 2022;Sameliuk et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum

Gutyj

Martyshuk

Парченко

et al. 2022

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

The balance between anti- and prooxidants in animal organisms in general and in each cell in particular is responsible for the regulation of many metabolic processes that provide immunocompetence, growth, development and protection of animals from oxidative stress, related to inflow of cadmium and plumbum. Therefore, the objective of our study was the influence of a liposomal drug based on interferon and milk thistle (Silybum marianum (L.) Gaertn.) on the antioxidative status of the organism of bulls in the conditions of cadmium and plumbum loading. The experiments were performed on six-months-old Black Motley dairy cattle. The fodders in the farm were determined to contain high levels of plumbum and cadmium. The liposomal drug Lipointersyl inhibited the lipid peroxidation processes in the bulls. The drug components promoted the decrease in the level of intermediate and end products of lipid peroxidation, in particular 22% decrease in the level of diene conjugates and 20% decrease in TBA-active products. Intramuscular injection of the liposomal drug to bulls of the experimental group strengthened the antioxidant protection of their organism. On the 30th day of the experiment, blood from experimental group animals was seen to have a 9.8% increase in reduced glutathione. Assay of the enzymatic link of the glutathione system revealed that the activity of glutathione peroxidase and glutathione reductase in the blood of the animals that had been injected the liposomal drug Lipointensyl had increased by 24.0% and 27.7% respectively by the 30th day of the experiment. The experiments conducted on young cattle demonstrated that intermuscularly injected the Lipointensyl liposomal drug – against the background of cadmium and plumbum loading – promoted the activation of the glutathione system of antioxidant protection as a result of increase in the activity of its enzymatic and non-enzymatic links. The study of catalase and superoxide dismutase activities revealed that on the 30th and 40th days of the experiment, the activity of those enzymes varied within the physiological norms. Therefore, the analyzed Silybum marianum-based liposomal drug has antioxidant properties, it is recommended for young cattle in the conditions of contamination with heavy metals in order to prevent the development of oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum

Gutyj

Martyshuk

Парченко

et al. 2022

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

show abstract

“…Thiothriazoline [ 149 ], thiometrizole (discovered at Zaporizhzia State Medical and Pharmaceutical University in Ukraine), and other thio-1,2,4-triazoles [ 150 , 151 , 152 , 153 , 154 , 155 ] have been identified as highly effective antioxidants and need to be tested as potential agents for relaxing oxidative stress and reprogramming the lipidome towards elevated PUFA levels.…”

Section: Therapeutic Strategies Based On the Metabolome And Lipidome ...mentioning

confidence: 99%

Hacking the Lipidome: New Ferroptosis Strategies in Cancer Therapy

Varynskyi,

Schick

2024

Biomedicines

View full text Add to dashboard Cite

The concept of redirecting metabolic pathways in cancer cells for therapeutic purposes has become a prominent theme in recent research. Now, with the advent of ferroptosis, a new chink in the armor has evolved that allows for repurposing of ferroptosis-sensitive lipids in order to trigger cell death. This review presents the historical context of lipidomic and metabolic alterations in cancer cells associated with ferroptosis sensitization. The main proferroptotic genes and pathways are identified as therapeutic targets for increasing susceptibility to ferroptosis. In this review, a particular emphasis is given to pathways in cancer cells such as de novo lipogenesis, which has been described as a potential target for ferroptosis sensitization. Additionally, we propose a connection between ketolysis inhibition and sensitivity to ferroptosis as a new vulnerability in cancer cells. The main proferroptotic genes and pathways have been identified as therapeutic targets for increasing susceptibility to ferroptosis. Proferroptotic metabolic pathways and vulnerable points, along with suggested agonists or antagonists, are also discussed. Finally, general therapeutic strategies for ferroptosis sensitization based on the manipulation of the lipidome in ferroptosis-resistant cancer cell lines are proposed.

show abstract

“…Nutrition is one of the key factors for normal growth and development of agricultural animals. Development of animals, poultry in particular, mainly depends on availability of feeds, which are the priority factors for maintenance, care, and diet (Fernández et al, 1995;Chen et al, 2016;Sameliuk et al, 2022). One of the most promising spheres is the search for new feed additives and development of effective schemes of using biological compounds that stimulate growth, development, and productivity of animals, and also boost the level of non-specific resistance (Hussain et al, 2016;Bomko et al, 2018;Gutyj et al, 2019;Kosenko et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Influence of protein-vitamin mineral supplements on the splenic morphometric parameters of quails

Dunaievska,

Horalskyi,

Sokulskiy

et al. 2023

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

Currently, a growing industrial poultry sphere in many countries is quail farming. Quails have a complex of unique economic-productive advantages, as compared with other poultry, – high body temperature, intensive metabolism, small size, fast maturation, and high egg productivity. In the study, we examined the specifics of microscopic structure of morphometry of the spleen of the control and experimental birds as characteristics sensitive to the action of supplements. The proposed methods are intended for studying effects of protein-vitamin mineral supplements on poultry farming. Therefore, for 21 days, with the main diet, the quails were given mineral supplements produced by the Multilife trade mark (crude protein, amino acids (lysine, threonine, methionine, cysteine), calcium, available phosphorus, sodium, chlorine, vitamins (A, D3, E)), by the Missi trademark (protein, vitamins, minerals), and by the Standard Agro trademark (soybean press cake, vitamins А, D3, Е, В1, В2, В6, В12), multi-enzyme complex, salt, ground limestone, phosphate monocalcium, amino acids (lysine, threonine, methionine with cysteine). This is the first study of the ultrastructural organization of the spleen of Japanese quail (Coturnix japonica) fed with protein-vitamin mineral supplements. The tested supplements were beneficial for the productivity of the quails, as evidenced by increase in the body and spleen weight. Body weight of the quails increased by 5.8% in the group that was fed additionally with the Multilife supplement, and by 12.5% in the group that consumed the Missi supplement added to the fodder, and by 8.1% in the group that consumed the Standard Agro supplement with the diet. At the same time, the spleen weight increased by 7.2%, 16.0%, and 10.5%, respectively. However, the relative weight (0.1%) underwent no changes, which characterizes this parameter as permanent for age and species of animals. Analysis of the data of our morphological studies revealed that the splenic microscopic structure of the quails was characterized by presence of support-contractile apparatus (capsule and trabeculae) with the relative area of 4.6 ± 0.8% and single radial trabecula. The parenchyma was formed by white and red pulps without distinct boundaries. In the white pulp, there were designated lymphoid nodes with no light centers, and also periarterial lymphoid sheaths and ellipsoids. In the reticular stroma of the white pulp of the spleen, we found blood cells of various maturity, in particular, lymphocytes, which were clearly divided into large, average, and small; mononuclear and multinuclear macrophages, which contained hemosiderin and melanin, leukocytes, mostly eosinophilous. The ultrastructural organization of the spleen of the quails had the following peculiarities: nuclei of leukocytes contained large nuclei, endotheliocytes of the central artery of lymphoid follicle performed phagocyte function by accumulating autophagosomes in its cytoplasm. In the quails that had consumed the diet containing supplements, the macroscopic, microscopic, and ultramicroscopic structures underwent no changes. At the same time, there was seen a tendency towards increase in the relative area of white pulp and the support-contractile apparatus. The relative area of white pulp of the spleen increased by 0.5% in the group of quails that had received the diet with the Multilife supplement, by 1% in the group that had consumed the diet with the Missi supplement, and by 0.6% in the group that had consumed the diet with the Standard Agro supplement. The relative area of the red pulp in the spleen of the quails was observed to have the tendency towards decrease: by 0.4% in the group that received the Multilife supplement, by 1% in the group that consumed the Missi supplement, and by 0.5% in the group that consumed the Standard Agro supplement. The relative area of the support-contractile apparatus of the spleen increased by 0.4% in the group of quails that consumed the Multilife supplement, by 1% in the group that consumed the Missi supplement, and 0.5% in the group that consumed the Standard Agro supplement. Taking into account the data we obtained, we may conclude that our studies confirm the benefits of using modern protein-vitamin supplements in poultry farming for stimulation of growth and development. Especially valuable is the absence of negative effect on the morphofunctional parameters of the spleen, which we used as biomarkers.

show abstract

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

Cited by 11 publications

References 67 publications

Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum

Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum

Hacking the Lipidome: New Ferroptosis Strategies in Cancer Therapy

Influence of protein-vitamin mineral supplements on the splenic morphometric parameters of quails

Contact Info

Product

Resources

About