Biological Activity of Organogermanium Compounds

Lukevics, É.; Игнатович, Л.

doi:10.1002/0470857188.ch23

Cited by 59 publications

(46 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These cations are plausible intermediates in reactions of silatranes and germatranes which possess a specific biological activity [11,12]. Molecular structures of silatranes and hypervalent bonding in their molecules were studied intensively [13].…”

Section: Introductionmentioning

confidence: 99%

Bonding in germatranyl cation and germatranes

Ignatyev

Sundius

Vrazhnov

et al. 2007

Journal of Organometallic Chemistry

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Bonding in germatranyl cation and germatranes

Ignatyev

Sundius

Vrazhnov

et al. 2007

Journal of Organometallic Chemistry

View full text Add to dashboard Cite

“…The development of a wide spectrum of Ge-132 biological activity has stimulated further research, especially in pharmacology concerning anti-cancer therapy (1,(21)(22)(23)(24). Ge-132 was treated as a strong analgetic and immunological systemsupporting remedy.…”

Section: Introductionmentioning

confidence: 99%

Benzylgermanium Compounds as Modifiers of Silica Gel Surface During a Chromatographic Process

Gadzała‐Kopciuch¹,

Pypowski²,

Chrząścik³

et al. 2010

Critical Reviews in Analytical Chemistry

View full text Add to dashboard Cite

In the paper are presented results of investigations concerning modification of silica gel by mono-, di-, and tribenzylgermanium during a chromatographic process. These compounds exhibit biological activity and are characterized by low toxicity. Germanium compounds are widely applied in oncological therapy. The investigations unambiguously show that the above mentioned derivatives can modify silica gel surface. These results have been confirmed by FTIR, 13 C CP/MAS NMR, 29 Si CP/MAS NMR and scanning microscopy. The strongest bonds are formed by monobenzyl derivative, slightly weaker bonds are formed by dibenzyl and the weakest bonds (because of sterically large group) formed by tribenzyl derivative. The mass ratio of germanium to silica after modification was monobenzyl derivative, for 15.02%, 11.05%, for dibenzyl and 7.10% for tribenzyl.

show abstract

“…1 Germanium-containing heterocycles are usually less toxic than their carbon and silicon analogues. [2][3][4] We have performed a comparative study of the vasodilating, anticoagulant and cardioprotective activity of 5-Si(Ge)-substituted isoxazolin-2-yl derivatives. The substitution of the silicon atom for the germanium does indeed lead to a significant increase in vasodilating, antithrombotic and cardioprotective activity.…”

Section: Introductionmentioning

confidence: 99%