In the paper are presented results of investigations concerning modification of silica gel by mono-, di-, and tribenzylgermanium during a chromatographic process. These compounds exhibit biological activity and are characterized by low toxicity. Germanium compounds are widely applied in oncological therapy. The investigations unambiguously show that the above mentioned derivatives can modify silica gel surface. These results have been confirmed by FTIR, 13 C CP/MAS NMR, 29 Si CP/MAS NMR and scanning microscopy. The strongest bonds are formed by monobenzyl derivative, slightly weaker bonds are formed by dibenzyl and the weakest bonds (because of sterically large group) formed by tribenzyl derivative. The mass ratio of germanium to silica after modification was monobenzyl derivative, for 15.02%, 11.05%, for dibenzyl and 7.10% for tribenzyl.
The compound 1-(N-morpholiniomethyl)spirobi (3-oxo-2,5-dioxa-1-silacyclopentan)ate crystallizes from aqueous solution of γ-butyrolactone in the form of two crystal hydrate modifications: monoclinic (with D = 1.53 g/cm 3 , space group P 2 1 /n) and triclinic (D = 1.45 g/cm 3 , space group P⎯1). For the monoclinic form, an X-ray structural study at -100ºC has been performed. For both structures the coordination polyhedron of the silicon atom is a trigonal bipyramid. In the crystal structures there are strong intermolecular hydrogen bonds of NH···O and OH···O types.
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