Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care products

Babizhayev, Mark A.

doi:10.1016/j.lfs.2005.09.054

Cited by 107 publications

(91 citation statements)

References 47 publications

(78 reference statements)

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“…19) To amplify skin hydration effect, urea and Tinocare GL were added to the hydrogel vehicle as humectants. Urea, a natural moisturizing factor, is beneficial for atopic skin since it helps reduce trandsepidermal water loss.…”

Section: Discussionmentioning

confidence: 99%

Hydrogel-Based Ultra-moisturizing Cream Formulation for Skin Hydration and Enhanced Dermal Drug Delivery

Lee

Kim

Cho

et al. 2014

Biological & Pharmaceutical Bulletin

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To develop an external vehicle for skin hydration and enhanced dermal drug delivery, a hydrogel-based ultra-moisturizing cream (HUMC) was successfully formulated with carbopol 934P, urea, Tinocare GL, grape seed oil, and other excipients. The HUMC showed plastic flow behavior due to a gel structure with a cream base. Different types of drug-free vehicles such as a hydrogel, conventional cream (CC), and three HUMCs were prepared and subjected to an in vivo skin hydration test on a hairless mouse using a corneometer. Hydration effect (

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Section: Discussionmentioning

confidence: 99%

Hydrogel-Based Ultra-moisturizing Cream Formulation for Skin Hydration and Enhanced Dermal Drug Delivery

Lee

Kim

Cho

et al. 2014

Biological & Pharmaceutical Bulletin

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“…The results of the recent study provide direct evidence that carcinine, as a novel histamine H3 receptor antagonist, plays an important role in histaminergic neurons activation and might be useful in the treatment of certain diseases, such as epilepsy, and locomotor or cognitive deficit [160]. In two of the reports, carcinine was shown to act as a natural antioxidant [161,162] and to play a role in regulating stress and shock with a 1000-fold less potent hypotensive effect than histamine [154,163], suggesting that carcinine might have therapeutic use (reviewed in ref. [164]).…”

Section: Telomere Shortening Telomerase Enhancers and Immune Systemmentioning

confidence: 96%

“…[164]). Overall, these low molecular mass antioxidant peptidomimetics add significantly to the host defense provided by the enzymes superoxide dismutase, catalase, and glutathione peroxidase and act as pharmacological chaperones in biological systems [132,135,161,162,165].…”

Section: Telomere Shortening Telomerase Enhancers and Immune Systemmentioning

confidence: 99%

Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting

Babizhayev¹,

Vishnyakova

Yegorov

2014

Journal of Basic and Clinical Physiology and Pharmacology

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It has been documented that telomere-associated cellular senescence may contribute to certain age-related disorders, and telomere length (TL) may be an informative biomarker of healthy aging. Hormone-brain-aging behaviormodulated telomere dynamics and changes in telomerase activity are consistent elements of cellular alterations associated with changes in proliferative state, and these processes are consequently considered as the new therapeutic drug targets for physiological control with advanced drug delivery and nutritional formulations. We raise and support a therapeutic concept of using nonhydrolyzed forms of naturally occurring neuron-specific imidazole dipeptide-based compounds carnosine and carcinine, making it clinically possible that slowing down the rate of telomere shortening could slow down the human aging process in specific tissues where proliferative senescence is known to occur, with the demonstrated evidence of telomere shortening that appeared to be a hallmark of oxidative stress and disease. Carnosine released from skeletal muscle during exercise may be transported into the hypothalamic tuberomammillary nucleus (TMN) histamine neurons and hydrolyzed. The resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of carnosine on neurotransmission and hormone-like antiaging physiological function. The preliminary longitudinal studies of elderly individuals suggest that longer telomeres are associated with better survival, and an advanced oral nutritional support with nonhydrolyzed carnosine (or carcinine and patented compositions thereof) is a useful therapeutic tool for a critical TL maintenance that may fundamentally be applied in the treatment of age-related sight-threatening eye disorders, prolonged life expectancy, increased survival and chronological age of an organism in health control, smoking behavior, and disease."Our pleasures were simple-they included survival." -Dwight D. Eisenhower, 34th President of the United States, 1953States, -1961

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“…Carcinine (-alanyl-L-histamine) is a natural imidazole-containing peptide derivative that has antioxidant properties and can scavenge reactive aldehydes produced by lipid peroxidation [35,36], thus preventing them from reacting with cellular proteins (manuscript submitted for publication). We have shown that intravitreal injection and systemic administration of carcinine protect wild-type photoreceptors from light-induced damage (manuscript submitted for publication).…”

Section: Alternative Strategy To Determine What Substrate Mediates Phmentioning

confidence: 99%

Mechanisms of RDH12-Induced Leber Congenital Amaurosis and Therapeutic Approaches

Kasus‐Jacobi¹,

Marchette²,

Xu³

et al. 2012

Advances in Ophthalmology

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Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care products

Cited by 107 publications

References 47 publications

Hydrogel-Based Ultra-moisturizing Cream Formulation for Skin Hydration and Enhanced Dermal Drug Delivery

Hydrogel-Based Ultra-moisturizing Cream Formulation for Skin Hydration and Enhanced Dermal Drug Delivery

Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting

Mechanisms of RDH12-Induced Leber Congenital Amaurosis and Therapeutic Approaches

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