2014
DOI: 10.1248/bpb.b14-00458
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Hydrogel-Based Ultra-moisturizing Cream Formulation for Skin Hydration and Enhanced Dermal Drug Delivery

Abstract: To develop an external vehicle for skin hydration and enhanced dermal drug delivery, a hydrogel-based ultra-moisturizing cream (HUMC) was successfully formulated with carbopol 934P, urea, Tinocare GL, grape seed oil, and other excipients. The HUMC showed plastic flow behavior due to a gel structure with a cream base. Different types of drug-free vehicles such as a hydrogel, conventional cream (CC), and three HUMCs were prepared and subjected to an in vivo skin hydration test on a hairless mouse using a corneom… Show more

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Cited by 16 publications
(14 citation statements)
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“…No changes on rheological behavior were observed for KT-C940-HG between 25 and 32°C although a slight decrease on viscosity was observed as the temperature increased, from 6.079 ± 0.037 to 5.057 ± 0.066 Pa·s (p < 0.05). Herschel-Bulkley model was the model that statistically best fitted rheological behaviour in ascending and descending stretches at 25°C (r = 0.9999) and 32°C (r2 = 0.9998) in KTC940-HG in line with others studies (24). KT-C940-HG also exhibited apparent thixotropy as the flow curves displayed hysteresis loops with the downward streches below the upward streches ( Fig.…”
Section: Characterizationsupporting
confidence: 88%
“…No changes on rheological behavior were observed for KT-C940-HG between 25 and 32°C although a slight decrease on viscosity was observed as the temperature increased, from 6.079 ± 0.037 to 5.057 ± 0.066 Pa·s (p < 0.05). Herschel-Bulkley model was the model that statistically best fitted rheological behaviour in ascending and descending stretches at 25°C (r = 0.9999) and 32°C (r2 = 0.9998) in KTC940-HG in line with others studies (24). KT-C940-HG also exhibited apparent thixotropy as the flow curves displayed hysteresis loops with the downward streches below the upward streches ( Fig.…”
Section: Characterizationsupporting
confidence: 88%
“…Water, a main component of hydrogels, is able to increase the hydration of the stratum corneum and acts as a natural penetration enhancer [35] . However, the tendency of hydrogels to rapid drying after application to the skin limits their moisturizing properties [36] . Solvents of the active substance that are the components of the liquid phase of the hydrogels (e.g.…”
Section: Hydrophilic Basesmentioning
confidence: 99%
“…Emulsion bases, especially emulgels and lamellar liquid layer crystal formulations, may increase the rate of the stratum corneum hydration [36] . Hydrophilic emulsions act similarly to hydrogels.…”
Section: Emulsion Basesmentioning
confidence: 99%
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