Biological activities of plant extracts from Ficus elastica and Selaginella vogelli : An antimalarial, antitrypanosomal and cytotoxity evaluation

Teinkela, Jean Emmanuel Mbosso; Siwe‐Noundou, Xavier; Nguemfo, Edwige Laure; Meyer, Franck; Wintjens, René; Isaacs, Michelle; Mpondo, Albert Emmanuel Mpondo; Hoppe, Heinrich C.; Krause, Rui Werner Maçedo; Azebaze, Anatole Guy Blaise

doi:10.1016/j.sjbs.2017.07.002

Cited by 29 publications

(21 citation statements)

References 39 publications

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“…Many studies reported that Ficus species are likely to kill cancer cells. The latex of F. carica L. inhibited human hypopharynx squamous carcinoma FaDu cells with an IC 50 value of 25 µg/ml (Shin et al., 2017), while aerial roots of F. elastic extracted with methanol showed IC 50 values of 20 µg/ml against human cervix adenocarcinoma (HeLa cells) (Mbosso Teinkela et al., 2018). However, our results suggested that caffeic acid and cyanidin in FD may not contribute to cancer cell toxicity.…”

Section: Resultsmentioning

confidence: 99%

Health‐promoting bioactivity and in vivo genotoxicity evaluation of a hemiepiphyte fig, Ficus dubia

Suttisansanee

Pitchakarn

Ting

et al. 2021

Food Science & Nutrition

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Ficus species have been used as a typical component in food and folk medicine in Asia for centuries. However, little is known regarding the bioactivity and genotoxicity of the recently identified Ficus dubia (FD), an indigenous plant of the tropical evergreen rain forest. FD is unique from other Ficus species because of its highly sought‐after red‐brown latex. Antioxidant properties together with phenolic and flavonoid contents of FD were elucidated. Health‐promoting characteristics were examined by studying the inhibition of enzymes as a drug target for diabetes, hypertension, Alzheimer's disease, and obesity, together with anticancer ability against human colorectal adenocarcinoma, human hepatocellular carcinoma, human ovarian carcinoma, human prostate adenocarcinoma, and human lung carcinoma. Besides, FD genotoxicity was tested using the Drosophila wing spot test. Results showed that both FD root and latex exhibited antioxidant activity due to the presence of phenolics and flavonoids, specifically caffeic acid and cyanidin. The ethanolic fraction of FD root demonstrated a potent antidiabetic mechanism underlying α‐glucosidase inhibitory activity similar to acarbose. This fraction also suppressed lung and ovarian cancer growth, possibly by G1 and G2/M arrest, respectively. All tested fractions lacked mutagenicity in vivo. Results indicated that FD can be developed as novel antidiabetic compounds; however, its bioactive compounds should be further identified.

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Section: Resultsmentioning

confidence: 99%

Health‐promoting bioactivity and in vivo genotoxicity evaluation of a hemiepiphyte fig, Ficus dubia

Suttisansanee

Pitchakarn

Ting

et al. 2021

Food Science & Nutrition

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“…The anticancer activity of MO leaves extracts was evaluated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium (MTT) reduction assay [36,37]. The sample of each extract was diluted in Dimethyl sulfoxide (DMSO) to obtain a concentration of 26, 52, 104, 206, and 416 μg mL −1 by microdilution assay [38].…”

Section: Anticancer Activitymentioning

confidence: 99%

Anticancer activities of phenolic compounds from Moringa oleifera leaves: in vitro and in silico mechanistic study

Mumtaz

Kausar

Hassan

et al. 2021

Beni-Suef Univ J Basic Appl Sci

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Background Moringa oleifera is a common vegetable in many countries since ancient times, possesses numerous phenolic compounds having a wide array of biological activities. It possesses anticancer activity that can be used to develop new drugs for treatment of various types of cancers. The current study was conducted to evaluate the composition of phenolic compounds and in vitro and in silico anticancer activities of M. oleifera leaves extracts. The leaves of M. oleifera were subjected to extraction for solvent fraction using n-hexane, chloroform, ethyl acetate, butanol, and aqueous solvents. The solvent fractions were tested for anticancer activity in vitro against Hela cancer cell line and screened for phenolic compounds through reversed-phase high-performance liquid chromatography. The molecular docking approach was employed to check binding conformations of phytochemicals against the target protein. Result The result revealed that all the solvent fractions possess in vitro anticancer activity against Hela cancer cell line. The n-hexane fraction showed a 50% reduction in Hela cancer cell viability at 416 μg mL−1 as compared to control. The extracts of solvent-fraction contained 10 phenolic compounds viz. quercetin, gallic acid, sinapic acid, vanillic acid, 4-hydroxy-3-methoxy benzoic acid, p-coumaric acid, m-coumaric acid, 4-hydroxy-3-methoxy cinnamic acid, caffeic acid, and syringic acid. Molecular docking studies revealed that the ligands bind within the active site of target protein have good binding energy values. Conclusion This study shows that M. oleifera leaves may have the potential to inhibit cancer cell growth and improving human health in addition to food ingredient innovations. Based on in vitro and in silico results, the phytochemicals from M. oleifera leaves can be used as leading drugs to treat cancer. Graphical abstract

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“…These plants were collected from 13 countries and areas, exemplified by Madagascar, Nigeria, South Africa and India. The antimalarial activity and toxicity of these plants are also presented in the table [ 7 , 64 , 72 , 73 , 74 , 75 , 76 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 100 ].…”

Section: Ethnologic Antimalarial Compoundsmentioning

confidence: 99%

Antimalarial Activity of Plant Metabolites

Pan

Shi

et al. 2018

IJMS

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Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to the identification of several potent antimalarial compounds. The prior comprehensive review article entitled “Antimalarial activity of plant metabolites” by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literature from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.

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Biological activities of plant extracts from Ficus elastica and Selaginella vogelli : An antimalarial, antitrypanosomal and cytotoxity evaluation

Cited by 29 publications

References 39 publications

Health‐promoting bioactivity and in vivo genotoxicity evaluation of a hemiepiphyte fig, Ficus dubia

Health‐promoting bioactivity and in vivo genotoxicity evaluation of a hemiepiphyte fig, Ficus dubia

Anticancer activities of phenolic compounds from Moringa oleifera leaves: in vitro and in silico mechanistic study

Antimalarial Activity of Plant Metabolites

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