Biological Activities of Natural Products

Ekiert, Halina; Szopa, Agnieszka

doi:10.3390/molecules25235769

Cited by 63 publications

(36 citation statements)

References 30 publications

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“…Natural products refer to a wide range of bioactive extracts or isolated metabolites from natural materials. Their bioactivities are currently of great interest in many research fields (Ekiert and Szopa, 2020) and may yield promising pharmacological approaches for the prevention and treatment of UC due to their multiple regulatory effects with few adverse effects (Nascimento et al, 2020). In recent years, converging lines of evidence have demonstrated that apoptosis of IECs is highly associated with the occurrence and development of UC.…”

Section: Discussionmentioning

confidence: 99%

Natural Products Modulate Cell Apoptosis: A Promising Way for the Treatment of Ulcerative Colitis

et al. 2022

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Ulcerative colitis (UC) is a chronic inflammatory bowel disease impacting patients’ quality of life and imposing heavy societal and economic burdens. Apoptosis of intestinal epithelial cells (IECs) has been considered an early event during the onset of UC and plays a crucial role in disease development. Thus, effectively inhibiting apoptosis of IECs is of critical significance for the clinical management of UC, presenting a potential direction for the research and development of pharmacotherapeutic agents. In recent years, research on the ameliorative effects of natural products on UC through inhibiting IECs apoptosis has attracted increasing attention and made remarkable achievements in ameliorating UC. In this review, we summarized the currently available research about the anti-apoptotic effects of natural products on UC and its mechanisms involving the death-receptor mediated pathway, mitochondrial-dependent pathway, ERS-mediated pathway, MAPK-mediated pathway, NF-κB mediated pathway, P13k/Akt pathway, JAK/STAT3 pathway, and NLRP3/ASC/Caspase-1 pathway. Hopefully, this review may yield useful information about the anti-apoptotic effects of natural products on UC and their potential molecular mechanisms and provide helpful insights for further investigations.

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Section: Discussionmentioning

confidence: 99%

Natural Products Modulate Cell Apoptosis: A Promising Way for the Treatment of Ulcerative Colitis

et al. 2022

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“…Natural products represent an important source of compounds used in the discovery of new therapeutic agents ( Harvey et al, 2015 ), which have relatively single compounds with good drug characteristics, including structural diversity and complexity, high selectivity and specific pharmacological activities, as well as novel therapeutic effects and mechanisms of action ( Barnett and Stallforth, 2018 ; Ekiert and Szopa, 2020 ). The importance of natural products in the prevention and treatment of heart disease is universally known.…”

Section: Introductionmentioning

confidence: 99%

Role of Higenamine in Heart Diseases: A Mini-Review

Wen

Zhang

et al. 2022

Front. Pharmacol.

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Higenamine, a natural product with multiple targets in heart diseases, is originally derived from Aconitum, which has been traditionally used in China for the treatment of heart disease, including heart failure, arrhythmia, bradycardia, cardiac ischemia/reperfusion injury, cardiac fibrosis, etc. This study is aimed to clarify the role of higenamine in heart diseases. Higenamine has effects on improving energy metabolism of cardiomyocytes, anti-cardiac fibroblast activation, anti-oxidative stress and anti-apoptosis. Accumulating evidence from various studies has shown that higenamine exerts a wide range of cardiovascular pharmacological effects in vivo and in vitro, including alleviating heart failure, reducing cardiac ischemia/reperfusion injury, attenuating pathological cardiac fibrosis and dysfunction. In addition, several clinical studies have reported that higenamine could continuously increase the heart rate levels of healthy volunteers as well as patients with heart disease, but there are variable effects on systolic blood pressure and diastolic blood pressure. Moreover, the heart protection and therapeutic effects of higenamine on heart disease are related to regulating LKB1/AMPKα/Sirt1, mediating the β2-AR/PI3K/AKT cascade, induction of heme oxygenase-1, suppressing TGF-β1/Smad signaling, and targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway. However, the interventional effects of higenamine on heart disease and its underlying mechanisms based on experimental studies have not yet been systematically reviewed. This paper reviewed the potential pharmacological mechanisms of higenamine on the prevention, treatment, and diagnosis of heart disease and clarified its clinical applications. The literature shows that higenamine may have a potent effect on complex heart diseases, and proves the profound medicinal value of higenamine in heart disease.

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“…Natural products are bioactive components from natural organisms, including plants, animals, insects, marine organisms, microorganisms ( Xie et al, 2021 ). These agents have been widely used by human societies for thousands of years ( Baker et al, 2007 ), and their bioactivities are of great interest to enormous research fields ( Ekiert and Szopa, 2020 ). In recent decades, a growing body of research has demonstrated that natural products exert anti-apoptotic effects on METH-induced neurotoxicity and may yield promising targets for further investigation of effective pharmacological interventions.…”

Section: Introductionmentioning

confidence: 99%

Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis

et al. 2022

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Methamphetamine (METH), an amphetamine-type psychostimulant, is highly abused worldwide. Chronic abuse of METH causes neurodegenerative changes in central dopaminergic neurons with numerous neuropsychiatric consequences. Neuronal apoptosis plays a critical role in METH-induced neurotoxicity and may provide promising pharmacological targets for preventing and treating METH addiction. In recent years, accumulating evidence has revealed that natural products may possess significant potentials to inhibit METH-evoked neuronal apoptosis. In this review, we summarized and analyzed the improvement effect of natural products on METH-induced neuronal apoptosis and their potential molecular mechanisms on modulating dopamine release, oxidative stress, mitochondrial-dependent apoptotic pathway, endoplasmic reticulum stress-mediated apoptotic pathway, and neuroinflammation. Hopefully, this review may highlight the potential value of natural products in modulating METH-caused neuronal apoptosis and provide useful information for future research and developments of novel and efficacious pharmacotherapies in this field.

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Biological Activities of Natural Products

Abstract: Natural products and their biological activities are currently a subject of great interest in the pharmaceutical, health food, and cosmetics industries, and numbers of scientific studies in this field are increasing rapidly [...]

Cited by 63 publications

References 30 publications

Natural Products Modulate Cell Apoptosis: A Promising Way for the Treatment of Ulcerative Colitis

Natural Products Modulate Cell Apoptosis: A Promising Way for the Treatment of Ulcerative Colitis

Role of Higenamine in Heart Diseases: A Mini-Review

Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis

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