Biological activities of frankincense essential oil in human dermal fibroblasts

Han, Xuesheng; Rodriguez, Damian; Parker, Tory L.

doi:10.1016/j.biopen.2017.01.003

Cited by 34 publications

(20 citation statements)

References 19 publications

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“…The system consists of three components: a cell type, stimuli to create the disease environment, and set of biomarker (protein) readouts to examine how treatments affect that disease environment (Berg et al, ). The methodologies used in this study were essentially the same as those previously described (Han and Parker, , ; Han et al, ).…”

Section: Methodsmentioning

confidence: 99%

Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model

Han¹,

Parker²

2017

Phytotherapy Research

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The effect of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) on human skin cells has not been elucidated. Therefore, we investigated the activity of a commercially available CBEO in a validated human dermal fibroblast system, a model of chronic inflammation and fibrosis. We first evaluated the impact of CBEO on 17 protein biomarkers that play critical roles in inflammation and tissue remodeling. The impact of CBEO on genome‐wide gene expression was also evaluated. CBEO showed strong anti‐proliferative effects on skin cells and significantly inhibited the production of several inflammatory biomarkers, including vascular cell adhesion molecule‐1, intercellular cell adhesion molecule‐1, monocyte chemoattractant protein‐1, interferon gamma‐induced protein 10, interferon‐inducible T‐cell alpha chemoattractant, and monokine induced by gamma interferon. In addition, CBEO significantly inhibited the production of several tissue remodeling molecules, including epidermal growth factor receptor, matrix metalloproteinase‐1, and plasminogen activator inhibitor‐1. Macrophage colony‐stimulating factor, which is an immunomodulatory protein molecule, was also significantly inhibited by CBEO. Furthermore, CBEO significantly modulated global gene expression and altered signaling pathways, many of which are important in inflammation, tissue remodeling, and cancer biology. The study shows that CBEO is a promising antiinflammatory agent; however, further research is required to clarify its clinical efficacy. © 2017 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.

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Section: Methodsmentioning

confidence: 99%

Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model

Han¹,

Parker²

2017

Phytotherapy Research

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“…All experiments were conducted in a BioMAP HDF3CGF system, a cell culture of human dermal fibroblasts that is designed to model chronic inflammation and fibrosis in a robust and reproducible way. The system consists of three components: a cell type, stimuli to create the disease environment, and a set of biomarker (protein) readouts to examine how treatments affect that disease environment [2] , [3] .…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory, tissue remodeling, immunomodulatory, and anticancer activities of oregano ( Origanum vulgare ) essential oil in a human skin disease model

Han¹,

Parker²

2017

Biochimie Open

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The use of oregano (Origanum vulgare) essential oil (OEO) has become popular in skin care products. However, scientific research regarding its effects on human skin cells is scarce. In this study, we investigated the biological activity of a commercially available OEO, which is high in carvacrol content, in a human skin cell disease model. OEO induced marked antiproliferative effects and significantly inhibited several inflammatory biomarkers, including monocyte chemoattractant protein 1 (MCP-1), vascular cell adhesion molecule 1 (VCAM-1), intracellular cell adhesion molecule 1 (ICAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG). OEO also significantly inhibited tissue remodeling biomarkers, namely collagen I, collagen III, epidermal growth factor receptor (EGFR), matrix metalloproteinase 1 (MMP-1), plasminogen activator inhibitor 1 (PAI-1), tissue inhibitor of metalloproteinase (TIMP) 1 and 2. An immunomodulatory biomarker, macrophage colony-stimulating factor (M-CSF), was also strongly inhibited by OEO treatment. In addition, OEO significantly modulated global gene expression and altered signaling pathways, many of which are critical in inflammation, tissue remodeling, and cancer signaling processes. These findings along with existing studies largely support the anti-inflammatory, tissue remodeling, immunomodulatory, and anticancer activities of OEO. In conclusion, this study provides the first evidence of the biological activity of OEO in human dermal fibroblasts. We suggest that OEO, with carvacrol as the major active component, is a promising candidate for use in skin care products with anti-inflammatory and anticancer properties.

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“…The system comprises three components: a cell type, stimuli to create the disease environment, and a set of biomarker (protein) readouts to examine how the treatments affected the disease environment [7] . The methodologies used in this study were essentially the same as those previously described [8] , [9] , [10] .…”

Section: Methodsmentioning

confidence: 99%

Lemongrass ( Cymbopogon flexuosus ) essential oil demonstrated anti-inflammatory effect in pre-inflamed human dermal fibroblasts

Han¹,

Parker²

2017

Biochimie Open

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Lemongrass (Cymbopogon flexuosus) essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of LEO on 17 protein biomarkers that are critically associated with inflammation and tissue remodeling. LEO significantly inhibited production of the inflammatory biomarkers vascular cell adhesion molecule 1 (VCAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG); decreased levels of the tissue remodeling biomarkers collagen-I and III, epidermal growth factor receptor (EGFR), and plasminogen activator inhibitor (PAI-1); and inhibited the immunomodulatory biomarker macrophage colony-stimulating factor (M-CSF). Furthermore, we studied the impact of LEO on genome-wide gene expression profiles. LEO significantly modulated global gene expression and robustly impacted signaling pathways, many of which are critical for inflammation and tissue remodeling processes. This study provides the first evidence of the anti-inflammatory activity of LEO in human skin cells and indicates that it is a good therapeutic candidate for treating inflammatory conditions of the skin.

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Biological activities of frankincense essential oil in human dermal fibroblasts

Cited by 34 publications

References 19 publications

Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model

Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model

Anti-inflammatory, tissue remodeling, immunomodulatory, and anticancer activities of oregano ( Origanum vulgare ) essential oil in a human skin disease model

Lemongrass ( Cymbopogon flexuosus ) essential oil demonstrated anti-inflammatory effect in pre-inflamed human dermal fibroblasts

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