Biological activities of extracts from endophytic fungi isolated from<i>Garcinia</i>plants

Phongpaichit, Souwalak; Nikom, Jaru; Rungjindamai, Nattawut; Sakayaroj, Jariya; Hutadilok‐Towatana, Nongporn; Rukachaisirikul, Vatcharin; Kirtikara, Kanyawim

doi:10.1111/j.1574-695x.2007.00331.x

Cited by 203 publications

(129 citation statements)

References 41 publications

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“…The antioxidant activity of observed methanol extract in S. jambos and E. deglupta was nearly the same, compared to ascorbic acid (3.94 µg/mL). The antioxidant activity with an IC 50 value of <10 µg/ml could be considered as a good antioxidant and an IC 50 value of 10-50 µg/ml could be considered as a powerful antioxidant [14].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity From Ten Species of Myrtaceae

Ramadhania

Insanu

Gunarti

et al. 2017

Asian J Pharm Clin Res

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Objective: Antioxidants are compounds that can inhibit free radical reactivity. They become very interesting to be observed because they can prevent some diseases such as goat arthritis, cancer, cardiovascular disease, Alzheimer's disease, and macular degeneration. Since Indonesia is rich for its biodiversity, there are a lot of plants that have potential to be developed as new alternative antioxidants. The aim of this research was to evaluate antioxidant activity from 10 species of Myrtaceae (Syzygium cumini, Syzygium samarangense, Syzygium aqueum, Syzygium aromaticum, Syzygium polyanthum, Syzygium jambos, Syzygium malaccense, Psidium guajava, Eucalyptus deglupta, and Melaleuca leucadendra). Methods:Continuous extraction with Soxhlet apparatus was selected as extraction method. Three solvents (n-hexane, ethyl acetate, and methanol) with different polarity were used in this process. 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity was used to evaluate antioxidant activity with ascorbic acid as a standard drug.Results: Based on the experiments, methanol extracts showed higher activity than other extracts with their inhibitory concentration 50% (IC 50 ) was below than 25 µg/ml. The lowest IC 50 was exhibited by methanol extract of S. jambos, which was 7.8 µg/ml. Conclusion:It can be concluded that S. jambos is potential to be developed as a new alternative antioxidant.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Activity From Ten Species of Myrtaceae

Ramadhania

Insanu

Gunarti

et al. 2017

Asian J Pharm Clin Res

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“…A sample of 1.0 g was applied to the skin surface. Then, at several time intervals (2,4,6,8,10,12,14,16,18,20, and 24 h) samples (3.0 mL) was taken from receptor compartment using a syringe and receptor compartment was refilled with the same amount of phosphate buffer pH 5.5. Next, the sample was inserted into the vial and its concentration measured by TLC-densitometry.…”

Section: In Vitro Penetration Testmentioning

confidence: 99%

Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

Ramadon¹,

Wirarti²,

Anwar³

2017

JYP

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Background: One of the natural products that have many benefits is green tea (Camellia sinensis L.). It can be used to maintain health because of its high antioxidant activity from epigallocatechin gallate (EGCG). However, EGCG has a low ability to penetrate through the skin due to its hydrophilicity. The aim of this study is to improve the penetration of EGCG through the skin by lipid nanovesicle, namely ethosome. Methods: Ethosomes were made using thin layer hydration method. Ethosomes were formulated with different concentration, equal to 1% (F1), 1.5% (F2), and 2% (F3) of EGCG from green tea leaves extract. They were characterized, then a chosen formula would be formulated into a gel dosage form (ethosomal gel). A gel without ethosome (non-ethosomal gel) was prepared as a control. Both of them were evaluated their penetration enhancement ability using Franz diffusion cells with the abdomen skin of Sprague-Dawley rats. Results and Discussion: Based on the results, F1 had a spherical shape, Dv90 129.00 ± 0.00 nm, polydispersity index 0.05 ± 0.00, zeta potential at -62.6 ± 5.05 mV, and the highest entrapment efficiency of 54.39 ± 0.03 %.

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“…For example, Strobel et al (2002) and Harper et al (2003) obtained two antioxidants, pestacin and isopestacin, from the endophytic fungi Pestalotiopsis microspora. Phongpaichit et al (2007) reported that 22.5% of the extracts from endophytic fungi and garcinia plants exhibited remarkable antioxidant activities. Recently, the endophytic fungi residing in Nerium oleander L. were shown to have excellent antioxidant capacity (with a TEAC value ranging from 9.59 to 150.79 μmol TE/100 mL culture in the ABTS assay) .…”

Section: Discussionmentioning

confidence: 99%

In vitro antioxidant activities of endophytic fungi isolated from the liverwort Scapania verrucosa

Zeng

Liao

et al. 2011

Genet. Mol. Res.

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ABSTRACT. We investigated in vitro antioxidant activities of 49 endophytic fungi isolated from the liverwort Scapania verrucosa. Based on morphological and molecular identification, the endophytic fungi isolated were classified into seven genera (Hypocrea, Penicillium, Tolypocladium, Chaetomium, Xylaria, Nemania, and Creosphaeria), all belonging to one family (Xylariaceae). By screening with the 2,2'-azinodi(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) decolorization assay, the ethyl acetate extracts of five endophytic fungi (T7, T21, T24, T32, and T38 strains), which exhibited remarkable Trolox equivalent (TE) antioxidant capacity (ranging from 997.06 to 1248.10 μmol TE/g extract), were selected and their antioxidant capacity was further evaluated by assays for 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, hydroxyl radical scavenging, reducing power, and ferrous ion chelating. The ethyl acetate extracts of two endophytic fungi (T24 and T38) were found to have comparable scavenging abilities on both DPPH-free radicals (93.9 and 88.7%, respectively, at 50 μg/mL) and hydroxyl radicals (97.1 and 89.4%, respectively, at 2 mg/mL) when compared with those of the positive controls (ascorbic acid and butylated hydroxytoluene, respectively). Although their reducing powers were similar to that of butylated hydroxytoluene, as indicated by absorbance (0.35 and 0.30 at 50 μg/mL, respectively), only the T38 strain's ethyl acetate extract showed ferrous ion chelating ability (92.9% at 1 mg/mL) comparable to that of the EDTA-2Na control. These endophytic fungi in S. verrucosa are a potential novel source of natural antioxidants.

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Biological activities of extracts from endophytic fungi isolated fromGarciniaplants

Cited by 203 publications

References 41 publications

Antioxidant Activity From Ten Species of Myrtaceae

Antioxidant Activity From Ten Species of Myrtaceae

Novel Transdermal Ethosomal Gel Containing Green Tea (Camellia sinensis L. Kuntze) Leaves Extract: Formulation and In vitro Penetration Study

In vitro antioxidant activities of endophytic fungi isolated from the liverwort Scapania verrucosa

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