Biological activities of a Turkish medicinal plant, Prangos platychlaena

Ulubelen, Ayhan; Topcu, Gülaçtı; Tan, Nur; Ölçal, S.; Johansson, Candan; Üçer, Murat; Birman, Hüsniye; Tamer, Sule

doi:10.1016/0378-8741(94)01215-l

Cited by 47 publications

(26 citation statements)

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“…The flowers are followed by narrowly ellipsoid to globose fruits, which may possess five straight to plicate wings (Davis, 1989;Rechinger, 1987). Some members of the genus are popular as sedative, digestive, tonic and aphrodisiac herbs, and they have been used in the treatment of intestinal worms, haemorrhoids, leukoplakic disease and bleeding in different regions of central Asia, Caucasia and the Mediterranean for a long time (Dokovic et al, 2004;Shikishima et al, 2001;Ulubelen et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Chemical variation of the essential oil ofPrangos ulopteraDC. at different stages of growth

Razavi¹,

Nazemiyeh²,

Delazar³

et al. 2011

Natural Product Research

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In the current investigation, the influence of the plant growth stages (prior to emergence of flower heads or vegetative, anthesis and fruiting) on the essential oil content and composition in the aerial parts of Prangos uloptera DC. was studied. Quantitative and qualitative differences were found among oil of aerial parts at three phenological stages. The principle compounds of the oil before emergence of flower heads were saferole (21.6%) and α-pinene (20%), while the oil at anthesis was composed of α-bisabolol (30.5%), saferole (19.11%) and (+)-spathulenol (12.9%). The oil at fruiting stage displayed γ-terpinene (35.5%) and trans-anethole (23.5%) as major constituents. These findings may confer valuable information regarding chemical composition of P. uloptera DC., which could be beneficial in the fields of herbal medicine.

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Section: Introductionmentioning

confidence: 99%

Chemical variation of the essential oil ofPrangos ulopteraDC. at different stages of growth

Razavi¹,

Nazemiyeh²,

Delazar³

et al. 2011

Natural Product Research

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confidence: 99%

Composition of the essential oils of Prangos scabra fruits and inflorescence from Iran

et al. 2007

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The chemical composition of Prangos scabra and component activities have been investigated by several authors [1][2][3][4][5][6]. The air-dried fruits and inflorescence of Prangos scabra yielded 1.6% and 0.3% of a pale yellow oil, respectively. In the DPPH assay, the essential oils of the fruits (EOF) and inflorescence (EOI) exhibited weak free radical scavenging activities with RC 50 values of 1.58 and 1.42 mg/mL, respectively.The identified compounds from these essential oils [7,8], their retention indices, amounts (%) are summarized in Table 1. In the present study, while 20 major components, 67.1% of which were sesquiterpenes and 23.3% oxygenated sesquiterpenes, were identified in the EOF, the EOI were found to contain 14 main components, among which 15% were sesquiterpenes and 45.3% were oxygenated sesquiterpenes.The two most abundant components of the EOF were identified as β-elemene (19.9%) and β-farnesene (16.2%), whereas the EOI consists of epi-globulol (21.1%) and β-elemene (19.7%) as the two major components. Among the oxygenated sesquiterpenes, epi-globulol, spathulenol, caryophyllenoxide, and α-cadinol were the main components. The EOF contained only a small amount of monoterpenes, β-pinene (0.1%) and D-limonene (0.3%), while no monoterpenes in the EOI were present in detectable amounts. It is interesting to note that β-pinene, D-limonene, germacrene D, valencene, α-bisabolol, γ-cadinene, germacrene B, elemol, p-cresol, and α-bisabolol were present in the EOF but not in the EOI. Similarly, β-selinene, calarene, and p-methoxyacetophenone were found in the EOI but not in the EOF (Table 1).A comparison of the essential oil composition of Prangos scabra with that of some other members of the genus Prangos, available in the literature [4,6,[9][10][11][12][13][14][15][16][17][18][19], shows that considerable variations exist in the compositions of the essential oils of different species of the genus Prangos, especially in terms of the type of major components present. It has been found that the most abundant component in the essential oils of P. uloptera [6,9,10,12], P. asperula subsp. haussknechth [11], P. bornmuelleri [15], P. heyniae [13], P. ferulaveae [18], and P. uechtritzii [13] were, respectively, α-pinene (15.0%), ∆ 3 -carene (16.1%), germacrene D (42%), β-bisabolene (53.3%), γ-terpinene (27.8%), and p-cymene (10.9%), whereas β-elemene was the main component of P. scabra. However, α-and β-pinene, germacrene D, and germacrene B are of common occurrence in the essential oils of fruits of nearly all investigated Prangos species. ACKNOWLEDGMENT

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“…Fifteen species of the genus Prangos are found in Iran, of which five are endemic (Mozaffarian, 1996). They have been used in Asian medicine as emollient, carminative (Zargari, 1992), tonic, antiflatulent, anthelmintic, antifungal, and antibacterial agents (Bouaoun et al, 2007;Ulubelen et al, 1995). Phytochemical investigations on different species of Prangos have led to the isolation of coumarins (Eshbakova et al, 2006;Razavi et al, 2008;Tada et al, 2002) and volatile oils (Baser et al, 2000;Sajjadi & Mehregan, 2003;Sajjadi et al, 2009Sajjadi et al, , 2011Sefidkon et al, 1998) from different parts of the plants.…”

Section: Introductionmentioning

confidence: 99%

Antiviral and cytotoxic evaluation of coumarins fromPrangos ferulacea

Shokoohinia

Sajjadi

Gholamzadeh

et al. 2014

Pharmaceutical Biology

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Context: Prangos ferulacea (L.) Lindl. (Apiaceae) is a perennial plant found in the Middle-East, where it is commonly used as an antispasmodic and anti-inflammatory agent. It is a rich source of coumarins. Objective: To purify several coumarins from P. ferulacea and to screen their cytotoxicity and antiherpes activity. Materials and methods: Acetone extract of roots of P. ferulacea was subjected to several chromatographic separations to render pure coumarins (1-8). Anti-herpes virus effects of 1-7 were evaluated at concentration 2.5, 5, and 10 mgmL À1 , on a confluent monolayer of Vero cells infected with 25 PFU of HSV1. Cytotoxic effects of 1 and 2 were evaluated on an A2780S cell line using the MTT assay. The cells were exposed to a series of concentrations of coumarins (0.01-2.5 mM, 37 C, 72 h). Results: Compounds 1-8 were identified as osthole, isoimperatorin, oxypeucedanin, psoralen, oxypeucedanin hydrate, gosferol, oxypeucedanin methnolate, and pranferol. This is the first report of occurrence of 4 and 7 in this plant. Compound 1 showed a viability of 9.41% ± 2.4 at 2.5 mM on A2780S cells (IC 50 ¼ 0.38 mM). The cell survival of 2 at 2.5 mM was 46.86% ± 5.5 with IC 50 equal to 1.1 mM. Discussion and conclusion: Compound 1 shows cytotoxic effects on the A2780S cell line. Compound 2 is a cyclooxygenase-2 inhibitor and the A2780S cell line does not express COX-2 which may interpret the non-toxic effect of the compound on this cell line. None of the tested compounds showed an anti-HSV effect at non-toxic concentrations.

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Biological activities of a Turkish medicinal plant, Prangos platychlaena

Cited by 47 publications

References 1 publication

Chemical variation of the essential oil ofPrangos ulopteraDC. at different stages of growth

Chemical variation of the essential oil ofPrangos ulopteraDC. at different stages of growth

Composition of the essential oils of Prangos scabra fruits and inflorescence from Iran

Antiviral and cytotoxic evaluation of coumarins fromPrangos ferulacea

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