Biologic Skin Substitutes

Phillips, Tania J.

doi:10.1111/j.1524-4725.1993.tb00426.x

Cited by 31 publications

(13 citation statements)

References 58 publications

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“…A number of preparations have been developed. Some contain living cells, such as fibroblasts or keratinocytes or both, while others are made of acellular materials or extracts of living cells [57,58].…”

Section: Bioengineered Skinmentioning

confidence: 99%

Wound healing and treatments for people with diabetic foot ulcers

Jeffcoate

Price

Harding

2004

Diabetes Metab. Res. Rev.

172

149

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The factors that delay wound healing are multiple and relate both to diabetes and to the effect of its complications. Diabetic foot ulcers readily become chronic, and chronic ulcers have biological properties that differ substantially from acute ones. Much of the available information on the biology of wound healing relates to acute and experimental wounds and may not be directly relevant. It follows that there is limited evidence currently available to underpin protocols for the management of diabetic foot ulcers, or to guide choice of applications and dressings 1. Nevertheless, it is possible to define certain principles.GLYCAEMIC CONTROL: The first relates to glycaemic control. While chronic complications of diabetes such as peripheral vascular disease and neuropathy may be largely irreversible, aspects of structure and function of connective tissue and cells may be impaired by hyperglycaemia, and their function should be improved if normoglycaemia is achieved. PROMOTION OF HEALING: The second principle concerns attempts at active promotion of wound healing by (1) surgical revascularization, and (2) specific attempts to correct defined biological abnormalities thought to be hindering the healing process. These include the use of a variety of applications, dressings and technologies, which may stimulate healing by applying, or stimulating the release of, growth factors and cytokines. While this approach holds the greatest promise for the future, it will be dependent on defining defects which need correction in specific individuals, and having technologies available to address them. This field is in its infancy. WOUND CARE: The third broad principle concerns the management of the wound and its surrounding tissue in order to promote healing. This includes regular inspection, cleansing and removal of surface debris, elimination of pathogenic bacteria and creation of an appropriate environment to facilitate endogenous tissue regeneration. There are many applications and dressings that may be chosen to promote healing, but, whichever is selected, wound management has to be integrated into an effective programme of multidisciplinary care.

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Section: Bioengineered Skinmentioning

confidence: 99%

Wound healing and treatments for people with diabetic foot ulcers

Jeffcoate

Price

Harding

2004

Diabetes Metab. Res. Rev.

172

149

View full text Add to dashboard Cite

show abstract

“…Cell culture and tissue engineering are crucial research techniques for studies on basic epithelial biology [3][4][5]. After Rheinwald and Green developed a method for culturing keratinocytes in vitro [6], Bell et al [7] created a reconstructed skin equivalent (rSE) that produced an in vitro environment physiologically similar to native epidermis.…”

Section: Introductionmentioning

confidence: 99%

Engraftment of umbilical cord epithelial cells in athymic mice: in an attempt to improve reconstructed skin equivalents used as epithelial composite

Sanmano¹,

Mizoguchi²,

Suga³

et al. 2005

Journal of Dermatological Science

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“…59 When cultured allogeneic keratinocytes were first used for the treatment of wounds it was thought that they might serve as a permanent skin substitute 60,61 because cultured allografts did not contain these antigen- presenting cells. More recent studies 4,15,62,63 suggest that these allografted keratinocytes act as a temporary wound covering that is eventually replaced by host cells. 1 Although indefinite survival of transplanted allogeneic tissue across major histocompatability barriers seems unlikely, 15 it is possible that the HSE "takes," becomes vascularized, and remodels over time.…”

Section: Mechanism Of Actionmentioning

confidence: 99%