Biologic correlation between glucose transporters, hexokinase-II, Ki-67 and FDG uptake in malignant melanoma

Park, Seok Gun; Lee, Jai Hyuen; Lee, Won Ae; Han, Kang Min

doi:10.1016/j.nucmedbio.2012.07.003

Cited by 47 publications

(45 citation statements)

References 31 publications

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“…6,7,9–14 The present results indicate that cellular uptake of FDG is mediated by GLUT-1. Higher GLUT-1 expression has also been proven to be associated with pancreatic cellular invasiveness.…”

Section: Discussionsupporting

confidence: 56%

“…9,12 Carbohydrate metabolism is more active in malignant cells, resulting in significant accumulation of FDG. 4–7,11 These changes in FDG uptake in the tumor may arise from the expression of GLUTs and glycolytic enzymes in tumor cells. A variety of studies using FDG-PET/CT have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…1 The prognosis of affected patients is poor, even if treated by pancreatectomy combined with adjuvant therapy such as chemotherapy and radiation therapy. 2,3 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) has been an important modality for detecting tumors, monitoring therapy, and evaluating the prognosis in several malignant cancers, 4–7 including pancreatic cancer. 8,9 The accumulation of FDG is based on the enhanced glycolysis of malignant tumor cells.…”

mentioning

confidence: 99%

“…9–12 This overexpression is reported to be closely related to FDG uptake. 7,9,10 Some studies have shown that increased glucose uptake and overexpression of GLUT-1 lead to a worse prognosis in invasive ductal carcinoma of the pancreas. 13,14 Epidermal growth factor receptor (EGFR) is overexpressed in approximately 50% to 60% of patients with invasive ductal carcinoma of the pancreas.…”

mentioning

confidence: 99%

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Maximum Standardized Uptake Value on 18F-Fluoro-2-Deoxy-Glucose Positron Emission Tomography/Computed Tomography and Glucose Transporter-1 Expression Correlates With Survival in Invasive Ductal Carcinoma of the Pancreas

Kitasato

Yasunaga²,

Okuda³

et al. 2014

Pancreas

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ObjectivesThe purpose of this study was to assess the correlations among the maximum standardized uptake value (SUVmax) on 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT); the expressions of glucose transporter 1 (GLUT-1), glucose transporter 3, and epidermal growth factor receptor (EGFR); as well as prognosis in patients with invasive ductal carcinoma of the pancreas.MethodsA total of 41 patients with surgically resected and histologically proven invasive ductal carcinoma of the pancreas who underwent preoperative FDG-PET/CT were assessed. The SUVmax at the primary tumor site was measured by FDG-PET/CT, and immunohistochemical staining of tumor sections was performed for GLUT-1, glucose transporter 3, and EGFR.ResultsHigher FDG uptake (SUVmax, >3.40) and GLUT-1 expression were significantly associated with shorter overall survival (P < 0.05). The SUVmax was not found to be significantly correlated with clinicopathological characteristics such as TNM classification, lymph node metastasis, and tumor differentiation. The EGFR expression was significantly correlated with the SUVmax (P = 0.024).ConclusionsHigher FDG uptake and GLUT-1 expression in invasive ductal carcinoma of the pancreas seems to be an important prognostic factor. In addition, the EGFR expression was significantly correlated with the SUVmax.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Maximum Standardized Uptake Value on 18F-Fluoro-2-Deoxy-Glucose Positron Emission Tomography/Computed Tomography and Glucose Transporter-1 Expression Correlates With Survival in Invasive Ductal Carcinoma of the Pancreas

Kitasato

Yasunaga²,

Okuda³

et al. 2014

Pancreas

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“…SUVmax has been correlated with tumor proliferation rate, tumor grade, and expression of glucose transporters, which are biomarkers in various types of malignant tumors (Takenaka et al, 2009;Taylor et al, 2009;Park et al, 2012). Metastasis is the major cause of death due to several malignancies, including NSCLC and it occur primary by dissemination through the lymphatic and blood vessels.…”

Section: Discussionmentioning

confidence: 99%

FDG PET-CT in Non-small Cell Lung Cancer: Relationship between Primary Tumor FDG Uptake and Extensional or Metastatic Potential

Zhu¹,

Zhang²,

Yu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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FDG PET/CT Scan and Functional Adrenal Tumors: A Pilot Study for Lateralization

et al. 2015

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Differential 18F-FDG PET/CT uptake was observed in patients with nonfunctioning, aldosterone-hypersecreting, and cortisol-secreting masses. GLUT3 overexpression in cortisol-secreting tumor likely accounts for the differential uptake. Future larger cohort studies will need to be conducted to determine if 18F-FDG PET/CT uptake can lateralize cortisol-secreting adrenal masses in patients with bilateral adrenal masses.

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Biologic correlation between glucose transporters, hexokinase-II, Ki-67 and FDG uptake in malignant melanoma

Cited by 47 publications

References 31 publications

Maximum Standardized Uptake Value on 18F-Fluoro-2-Deoxy-Glucose Positron Emission Tomography/Computed Tomography and Glucose Transporter-1 Expression Correlates With Survival in Invasive Ductal Carcinoma of the Pancreas

Maximum Standardized Uptake Value on 18F-Fluoro-2-Deoxy-Glucose Positron Emission Tomography/Computed Tomography and Glucose Transporter-1 Expression Correlates With Survival in Invasive Ductal Carcinoma of the Pancreas

FDG PET-CT in Non-small Cell Lung Cancer: Relationship between Primary Tumor FDG Uptake and Extensional or Metastatic Potential

FDG PET/CT Scan and Functional Adrenal Tumors: A Pilot Study for Lateralization

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