Biologic Activity of Cold-Reacting Autoantibodies

Pruzanski, W.; Shumak, Kenneth H.

doi:10.1056/nejm197709152971105

Cited by 128 publications

(71 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…anti-I Ma of the chronic lymphocytic leukemia cells (relative to normal lymphocytes) is also in agreement with previous data (3,24).…”

Section: Discussionsupporting

confidence: 93%

“…They are recognized by human autoantibodies, most of which are coldreactive monoclonal IgM proteins (2). However, these antigens are not confined to human erythrocytes; they have been detected on human lymphocytes, polymorphonuclear leukocytes, macrophages (3), and various cultured cells (4,5) and in water-soluble form in certain secretions (2). Moreover, they are variably expressed on erythrocytes (6) and cultured cell lines of several animal species (7,8).…”

mentioning

confidence: 99%

See 1 more Smart Citation

I and i antigens of human peripheral blood lymphocytes cocap with receptors for concanavalin A.

Feizi

Kapadia

Yount³

1980

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Surface immunofluorescence experiments using a human anti-i and two anti-I antisera have been performed on human peripheral blood lymphocytes. These are known to contain cold-reactive monoclonal IgM antibodies against the carbohydrate sequence:Galfl -4GlcNAc#1 -3Galjfl 4GlcNAc/31 -3Gal-(anti-i Den) and the 1 --4, 1 -6 domain (anti-I Ma) and the 1 --4, 1 3 domain (anti-I Step) of the branched I-active structure:Galf1l 4GlcNAcfll \6G lfli -4GIcNAcfl -3Gal-A high proportion of B-and T-type lymphocytes express these I and i determinants. In the presence of anti-human immunoglobulin, the cold-reactive membrane-associated complexes of I-anti-I and i-anti-i become stabilized, and redistribution (with patching and capping) can be elicited at 370C. Dual fluorescence experiments have shown striking concordant staining of I or i (fluorescein) caps and patches with concanavalin A (rhodamine) reactive sites on normal and leukemic cells, suggesting that a proportion of I and i active structures of lymphocyte membranes are structurally associated or physiologically coupled with glycoproteins carrying oligosaccharides with branched mannosyl cores.

show abstract

“…anti-I Ma of the chronic lymphocytic leukemia cells (relative to normal lymphocytes) is also in agreement with previous data (3,24).…”

Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

I and i antigens of human peripheral blood lymphocytes cocap with receptors for concanavalin A.

Feizi

Kapadia

Yount³

1980

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Corp., Norwalk, CT), the same C,, primer and 5' primers complementary to the conserved portion ofpublished leader sequences for each VH gene family (1)(2)(3)(4)(5)(6) (Table I). The same approach was used to isolate the VL region gene sequences.…”

Section: Methodsmentioning

confidence: 99%

“…For example, virtually all sera from healthy individuals contain low concentrations of naturally occurring anti-i /I IgM anti-red blood cell (RBC) antibodies or cold agglutinins (CA)' that cause no apparent immune hemolysis. The pathogenic counterparts of these autoantibodies may cause severe immune hemolytic anemia and are generally derived from monoclonal B cell expansions that may progress to frank lymphoma (3). The anti-i and anti-I specificities of CA are broadly defined by their differential reactivities to cord (predominantly i-expressing) vs adult (predominantly Iexpressing) RBCs.…”

Section: Introductionmentioning

confidence: 99%

Naturally occurring anti-i/I cold agglutinins may be encoded by different VH3 genes as well as the VH4.21 gene segment.

Jefferies¹,

Carchidi²,

Silberstein³

1993

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…This monoclonal immunoglobulin is generally IgM Kappa, which often interacts with I/i antigens on the surface of erythrocytes. 23,24 Anemia manifests in less than 10% of patients and is generally associated with "cold agglutinins" levels above 1:1000. 25 The reduction in the temperature of blood flowing through the peripheral blood vessels favors the binding of IgM "cold agglutinins" to the surface of erythrocytes.…”

Section: Clinical Symptomsmentioning

confidence: 99%

Waldenström's macroglobulinemia - a review

Coimbra

Neves

Lima

et al. 2014

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Waldenström's macroglobulinemia (WM) is a lymphoproliferative disease of B lymphocytes, characterized by a lymphoplasmocytic lymphoma in the bone marrow and by IgM monoclonal hypergammaglobulinemia. It was first described in 1944 by Jan Gösta Waldenström, reporting two patients with oronasal bleeding, lymphadenopathy, anemia, thrombocytopenia, high erythrocyte sedimentation rate and serum viscosity, normal radiography and bone marrow infiltrated by lymphoid cells. The WM is a rare disease with a typically indolent clinical course, affecting mainly individuals aged between 63 and 68 years. Most patients have clinical signs and symptoms related to hyperviscosity resulting from IgM monoclonal gammopathy, and/or cytopenias resulting from bone marrow infiltration by lymphoma. The differential diagnosis with other lymphomas is essential for the assessment of prognosis and therapeutic approach. Treatment of patients with asymptomatic WM does not improve the quality of life of patients, or increase their survival, being recommended, therefore, their follow-up. For the treatment of symptomatic patients, alkylating agents, purine analogs and anti-CD20 monoclonal antibodies are used. However, the disease is incurable and the response to therapy is not always favorable. Recent studies have shown promising results with bortezomib, an inhibitor of proteasomes, and some patients respond to thalidomide. In patients with relapse or refractory to therapy, autologous transplantation may be indicated. The aim of this paper is to describe in detail the current knowledge on the pathophysiology of WM, main clinical manifestations, diagnosis, prognosis and treatment.

show abstract

Biologic Activity of Cold-Reacting Autoantibodies

Cited by 128 publications

References 51 publications

I and i antigens of human peripheral blood lymphocytes cocap with receptors for concanavalin A.

I and i antigens of human peripheral blood lymphocytes cocap with receptors for concanavalin A.

Naturally occurring anti-i/I cold agglutinins may be encoded by different VH3 genes as well as the VH4.21 gene segment.

Waldenström's macroglobulinemia - a review

Contact Info

Product

Resources

About