Bioinspired polydopamine coating‐assisted electrospun polyurethane‐graphene oxide nanofibers for bone tissue engineering application

To investigate the potential of biomaterials for bone repair, Ginkgo biloba (GB)-loaded polylactic- co-glycolic acid microspheres were synthesized via solvent evaporation technique, and scanning electron microscopic (SEM) micrographs indicated a spherical and smooth surface in which the particles were distributed in the range of 1–7 µm. Chitosan–hydroxyapatite (HA) matrixes incorporated with polymeric spheres were fabricated using the freeze-drying method. SEM micrographs demonstrated an interconnected porous structure in which porosity and pore size reduced as a function of HA and microsphere addition. Fourier transform infrared spectrum illustrated the ability of sodium tripolyphosphate in cross-linking of composite scaffolds. Swelling ratio presented that higher amount of microspheres and the addition of HA reduce the ability of interaction with water molecules. The GB release behavior of hybrid scaffolds confirmed that the addition of HA significantly reduces release ratio because of a slight reduction in pore size and PBS absorption capacity, but higher amount of microspheres resulted in an increase in release level. According to the results, the synthesized hybrid scaffolds have the initial physicochemical features for further studies in terms of in vitro and in vivo assays.

show abstract

“…where V p is the volume of the scaffold pores; V S is the volume of the matrix; ρ s is the density; and ε is the porosity. 28…”

Section: Methodsmentioning

confidence: 99%

Physicochemical properties of chitosan–hydroxyapatite matrix incorporated with Ginkgo biloba-loaded PLGA microspheres for tissue engineering applications

Marouf

Nojehdehian

Ghorbani

2019

Polymers and Polymer Composites

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several in vitro studies have demonstrated that PDA and DOPA coatings are effective in promoting stem cells and osteoblasts adhesion and growth on different fibrous scaffolds [ 125 , 126 , 127 , 128 , 129 ]. For example, a recent study has investigated the behavior of osteoblast-like cells exposed to a PDA-coated polyurethane (PU)-GO electrospun scaffold [ 130 ]. PDA deposition did not affect the structure of the PU-GO scaffold but significantly improved its hydrophilicity.…”

Section: Melanins and Melanin-like Materials In Tissue Engineeringmentioning

confidence: 99%

“…( d ) alkaline phosphatase (ALP) activity of MG-63 cultured in the presence or absence of PDA, for 1, 3, and 7 days (* p < 0.05, ** p < 0.005, *** p < 0.0005, **** p < 0.00005). Reproduced with permission from [ 130 ]. Copyright John Wiley and Sons, 2019.…”

Section: Figurementioning

confidence: 99%

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

et al. 2020

View full text Add to dashboard Cite

Melanins are a group of dark insoluble pigments found widespread in nature. In mammals, the brown-black eumelanins and the reddish-yellow pheomelanins are the main determinants of skin, hair, and eye pigmentation and play a significant role in photoprotection as well as in many biological functions ensuring homeostasis. Due to their broad-spectrum light absorption, radical scavenging, electric conductivity, and paramagnetic behavior, eumelanins are widely studied in the biomedical field. The continuing advancements in the development of biomimetic design strategies offer novel opportunities toward specifically engineered multifunctional biomaterials for regenerative medicine. Melanin and melanin-like coatings have been shown to increase cell attachment and proliferation on different substrates and to promote and ameliorate skin, bone, and nerve defect healing in several in vivo models. Herein, the state of the art and future perspectives of melanins as promising bioinspired platforms for natural regeneration processes are highlighted and discussed.

show abstract

“…Each material has a particular feature which will contribute to the overall efficacy of the scaffold. Conventionally, polymeric (synthetic and natural) and non‐polymeric materials are used for the fabrication of nanofiber scaffolds …”

Section: Introductionmentioning

confidence: 99%

Graphene oxide incorporated polycaprolactone/chitosan/collagen electrospun scaffold: Enhanced osteogenic properties for bone tissue engineering

et al. 2019

Self Cite

View full text Add to dashboard Cite

This in vitro study aimed to evaluate the physicochemical and biological activity of the polycaprolactone/chitosan/collagen scaffolds incorporated with 0, 0.5, 3, and 6 wt% of graphene oxide (GO). Using standard tests and MG-63 cells, the characteristics of scaffolds were evaluated, and the behavior of osteoblasts were simulated, respectively. A non-significant decrease in nanofibers diameter was noted in scaffolds with a higher ratio of GO. The hydrophilicity and bioactivity of the scaffold surface, as well as cell attachment and proliferation, increased in correspondence to an increase in GO. The higher ratio of GO also improved the osteogenesis activity.GO increased the degradation rate, but it was negligible and seemed not enough to endanger stability. Modifying the scaffolds with GO did not make a significant change to the antibacterial effect.

show abstract

Bioinspired polydopamine coating‐assisted electrospun polyurethane‐graphene oxide nanofibers for bone tissue engineering application

Cited by 38 publications

References 69 publications

Physicochemical properties of chitosan–hydroxyapatite matrix incorporated with Ginkgo biloba-loaded PLGA microspheres for tissue engineering applications

Physicochemical properties of chitosan–hydroxyapatite matrix incorporated with Ginkgo biloba-loaded PLGA microspheres for tissue engineering applications

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

Graphene oxide incorporated polycaprolactone/chitosan/collagen electrospun scaffold: Enhanced osteogenic properties for bone tissue engineering

Contact Info

Product

Resources

About