Bioinspired-Interpenetrating Network (IPNs) Hydrogel (BIOF-INPs) and TMD <i>in Vitro</i>: Bioadhesion, Drug Release and Build in Free Radical Detection and Defense

Abstract

In this work, Bioactive-functionalized interpenetrating network (IPNs) hydrogel (BIOF-INPs) were prepared and investigated in vitro for the free radical detection/defense, therapeutic release as well as shear bond strength to dentine, ability to re-mineralize surface of the dentin after application of these bio-inspired materials using a biologically inspired mineralization process in vitro as well as investigating antimicrobial properties of the BIOF-INPs against S. aureous. The aim of this investigation was to evaluate the suitability and flexibility of the designer materials to act as an "in vitro" probe to gain insights into molecular origin of TMD and associated disorders.

Chitosan Bio-Active Designer Materials and Orthodontics: Development and Evaluation of Novel Materials as Enamel Protective Agents

“…Previous studies [22][23][24][25] with Scanning Electron Microscope (SEM) indicated that although self-etch priming agents have the potential to etch the enamel surface, the etching pattern is less deep compared to the etching pattern of phosphoric acid. A chemical bonding capacity through the interaction between some functional monomers and the calcium of residual hydroxyapatite may contribute favorably to the bonding effectiveness [26][27][28][29] but, fluoride affects the enamel surface rendering it more resistant to demineralization. Fluoride in low concentrations favors the formation of fluoro-hydroxyapatite, which is less susceptible to acidic solubility than hydroxyapatite [34,35].…”

Cytotoxicity of Different Degrees of De-Acetylated Chitosan on 3T3- and Two Human Tooth Fibroblast Cell-Lines

“…Chitosan is hypoallergenic and has natural antibacterial properties, which further support its use in the army as field bandages [8]. Furthermore, antioxidant-chitosan hydrogels (that of resveratrol, propolis and β-carotene) were found to significantly improve the bond strength to dentine with or without phosphoric acid pre-treatment [9] as many other hydrogels do [10].…”

Towards Bioactive Dental Restorative Materials with Chitosan and Nanodiamonds: Evaluation and Application

“…The adequate water absorption capacity, together with its cationic nature, which promotes binding to the negative surface of dentin (or skin) can also explain these results. Hydration of the polymer causes mobilization of the polymer chains and hence influences polymeric adhesion [24]. Appropriate swelling is also important to guarantee bio-adhesion.…”

“…Appropriate swelling is also important to guarantee bio-adhesion. However, over-hydration can form slippery non-adhesive hydrogels [24]. Chitosan and cyclodextrin are potent antioxidants with multiple free hydroxyl groups [25].…”