Bioinspired Integration of Naturally Occurring Molecules towards Universal and Smart Antibacterial Coatings

Abstract

Surface-independent smart antibacterial coatings with on-demand antibiotics release profiles have attracted increasing attention in medical instruments, antibiotics delivery platforms, and implanted devices. Although several approaches have been well documented, the facile preparation of antibacterial coatings onto universal substrates with high antibiotics loading efficiencies, tunable drug release profiles, and excellent antibacterial performances is still met with many challenges, especially related to the redundant coating material synthesis and selective substrate fabrication process. To resolve this issue, the authors report a facile and robust fabrication method towards smart antibacterial coating surfaces on various substrates via a one-pot integration of two types of naturally occurring building blocks, aminoglycosides and protocatechualdehyde in the presence of plant enzyme horseradish peroxidase. The simultaneous dynamic imine bonds formation and enzymatic polymerization within the system during the one-pot reaction enable the facile fabrication of diverse surface-independent smart antibacterial coatings, which can demonstrate several promising features including high drug loading and dynamic (i.e., pH-responsive) properties, tunable and on-demand antibiotics release behaviors, and efficient antibacterial activities both in vitro and in vivo. This work may offer new opportunities towards the robust and universal antibacterial coating materials by the bioinspired integration of all natural building blocks.

Layer‐by‐Layer Assembled Smart Antibacterial Coatings via Mussel‐Inspired Polymerization and Dynamic Covalent Chemistry

“…In particular, the mussel-inspired oxidative polymerization of DHI could afford the first polycatechol layer of adhesive coatings on various surfaces ranging from organic substrates [i.e., polyethersulfone (PES), polyamide (PA)] to inorganic substrates (i.e., glass, Al 2 O 3 ), and even to Teflon substrates, which might be attributed to the presence of strong and hierarchical covalent and noncovalent interactions. [33,34] In addition, the multiple FPBA and AGs small molecules were then sequentially introduced onto the coating layer via boronatecatechol complexation and Schiff base reaction, respectively. Both of the formed imine and boronate ester bonds performed dynamic features and could be rapidly cleaved when suffering from the acidic microenvironments induced by bacterial colonization, which could trigger the fast release of AGs for antibacterial applications.…”

Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application

“…On the other hand, causing surface hydrophilicity can also decrease the total contact and inhibit bacterial adhesion, because the hydrophilicity helps to reduce the number of bacteria proteins attached to the surface. A simple way to make surfaces hydrophilic is directly coating hydrophilic components such as polymers and zwitterions [ 75 , 76 , 77 , 78 , 79 ]. For example, a branched-chain-polymer-based surface with antibiofouling properties was developed by conjugating dioxy-containing polyethylene glycol with gentamicin terminals.…”

pH-Responsive PVA/BC-f-GO Dressing Materials for Burn and Chronic Wound Healing with Curcumin Release Kinetics

“…Hydrogels are typically made up of natural or synthetic polymers. However, they lack mechanical properties, biodegradation, and a low swelling ratio, limiting their clinical use as chronic wound dressings [ 13 , 14 ].…”