Bioinspired<i>Camellia japonica</i>carbon dots with high near-infrared absorbance for efficient photothermal cancer therapy

Kim, Dohun; Jo, Gayoung; Chae, Yujin; Surendran, Subramani; Lee, Bo Young; Kim, Eun Jeong; Ji, Min-Kyung; Hyun, Hoon

doi:10.1039/d1nr03999g

Cited by 46 publications

(27 citation statements)

References 41 publications

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“…Mice were intravenously administered with CA800Cl (10 nmol, 0.23 mg/kg) or PBS 24 h before laser irradiation and exposed to an 808 nm laser (1.1 W/cm 2 ) for 5 min. Previously, the power density of the 808 nm laser was optimally adjusted to prevent unnecessary damage in normal tissue owing to laser power alone, without any PTT agent [ 23 , 24 ]. The temperature of the tumors treated with CA800Cl markedly increased up to 54.9 °C after 5 min of laser irradiation, whereas tumor temperatures in the PBS-injected mice exhibited minimal change (39 °C) under the same condition ( Figure 5 d).…”

Section: Resultsmentioning

confidence: 99%

Molecular Tuning of IR-786 for Improved Tumor Imaging and Photothermal Therapy

Lim

Byun²,

et al. 2022

Pharmaceutics

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A tumor-targeted near-infrared (NIR) fluorophore CA800Cl was developed based on commercially available IR-786 by modulating its physicochemical properties. IR-786, a hydrophobic cationic heptamethine cyanine fluorophore, was previously recognized as a mitochondria-targeting NIR agent with excellent optical properties. Owing to the poor tumor specificity of IR-786 itself, in vivo studies on tumor-targeted imaging have not yet been investigated. A chloro-cyclohexene ring and indolium side groups on the heptamethine chain are key structural features that improve tumor targetability, owing to better biodistribution and clearance. Thus, IR-786 should be designed to be more soluble in aqueous solutions so that it can preferentially accumulate in the tumor based on the structure-inherent targeting strategy. In this study, we developed a bifunctional NIR fluorophore CA800Cl by incorporating carboxylate moieties in the basic structure of IR-786. This improved its tumor targetability and water solubility, thereby enabling the use of CA800Cl for enhanced photothermal cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Molecular Tuning of IR-786 for Improved Tumor Imaging and Photothermal Therapy

Lim

Byun²,

et al. 2022

Pharmaceutics

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“…To confirm the photothermal properties of ZW800-AM, ZW800-AM (100 µM in PBS) and PBS solutions were individually exposed to 808 nm laser irradiation (1.1 W/cm 2 ) for 1 min. Previously, the power density of an 808 nm laser was determined optimal, capable of avoiding the unnecessary photothermal effect of only laser power, without any PTT agent [26,27]. Temperature changes during the laser irradiation were automatically recorded using an FLIR ® thermal imager as a function of the irradiation time.…”

Section: In Vitro and In Vivo Photothermal Effectsmentioning

confidence: 99%

Tumor-Targeted ZW800-1 Analog for Enhanced Tumor Imaging and Photothermal Therapy

Park

Kim

et al. 2021

Pharmaceutics

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ZW800-1, a representative zwitterionic near-infrared (NIR) fluorophore, can minimize background tissue uptake owing to its balanced surface charges, and therefore, is widely used for improved NIR fluorescence imaging. As ZW800-1 has no tumor targetability, tumor imaging is highly dependent on the ability of the molecules conjugated to the ZW800-1. To enable tumor targeting using ZW800-1 without additional conjugation, we developed a tumor-targetable and renal-clearable ZW800-1 analog (ZW800-AM) based on the structural modification of ZW800-1. Specifically, an amine group on the center linker of the ZW800-1 indocyanine backbone was modified by replacing phenoxypropionic acid with tyramine linkage on the meso-chlorine atom. This modification improved the tumor targeting ability, which is known as the structure-inherent targeting strategy. More importantly, ZW800-AM not only showed sufficient tumor accumulation without nonspecific uptake but also produced a photothermal effect, killing tumor cells under 808 nm NIR laser irradiation. In addition, ZW800-AM exhibited rapid renal elimination from the body within 4 h of injection, similar to ZW800-1. Overall, the discovery of ZW800-AM as a bifunctional phototherapeutic agent may provide an ideal alternative for tumor-targeted imaging and phototherapy.

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“…For both types of synthesis, depending on the temperature or power, reaction time and precursor, the physicochemical properties of the CDs, such as size, crystallinity, solubility, can be controlled. Precursors can be obtained from renewable sources, such as orange juice [ 61 ], shrimp egg [ 62 ], ginkgo leaves [ 63 ], extract of waste tea [ 64 ], pine pollen [ 65 ], Camellia japonica flowers [ 66 ], or waste cotton linter [ 42 ]. Other renewable sources are reviewed elsewhere [ 67 ].…”

Section: Strategies For Cds Synthesismentioning

confidence: 99%

Applications of Carbon Dots for the Photocatalytic and Electrocatalytic Reduction of CO2

et al. 2022

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The photocatalytic and electrocatalytic conversion of CO2 has the potential to provide valuable products, such as chemicals or fuels of interest, at low cost while maintaining a circular carbon cycle. In this context, carbon dots possess optical and electrochemical properties that make them suitable candidates to participate in the reaction, either as a single component or forming part of more elaborate catalytic systems. In this review, we describe several strategies where the carbon dots participate, both with amorphous and graphitic structures, in the photocatalysis or electrochemical catalysis of CO2 to provide different carbon-containing products of interest. The role of the carbon dots is analyzed as a function of their redox and light absorption characteristics and their complementarity with other known catalytic systems. Moreover, detailed information about synthetic procedures is also reviewed.

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BioinspiredCamellia japonicacarbon dots with high near-infrared absorbance for efficient photothermal cancer therapy

Abstract: Since carbon dots (CDs) exhibit excellent biocompatibility, low cytotoxicity, near-infrared (NIR) absorbance, and superior photostability, many types of CDs are considered as powerful candidates for photothermal therapy (PTT) applications. However,...

Cited by 46 publications

References 41 publications

Molecular Tuning of IR-786 for Improved Tumor Imaging and Photothermal Therapy

Molecular Tuning of IR-786 for Improved Tumor Imaging and Photothermal Therapy

Tumor-Targeted ZW800-1 Analog for Enhanced Tumor Imaging and Photothermal Therapy

Applications of Carbon Dots for the Photocatalytic and Electrocatalytic Reduction of CO2

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