Bioinspired green-synthesized silver nanoparticles: <i>in vitro</i> physicochemical, antibacterial, biofilm inhibitory, genotoxicity, antidiabetic, antioxidant, and anticoagulant performance

Barabadi, Hamed; Hosseini, Omid; Jounaki, Kamyar; Sadeghian-Abadi, Salar; Ashouri, Fatemeh; Mostafa Abdulabbas Alrikabi, Ayat; Vahidi, Hossein; Amidi, Salimeh; Mojab, Faraz; Mohammadi, Neda; Mostafavi, Ebrahim

doi:10.1039/d3ma00089c

Cited by 20 publications

(5 citation statements)

References 59 publications

(84 reference statements)

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“…For example, the Anticoagulant activity of AgNPs mycogenically synthesized using Bacillus safensis LAU 13 cell-free extract was examined visually by Lateef et al. [41] According to the research depicted in Figures 4 a and b, it was discovered that AgNPs had strong Anticoagulant properties and inhibited the Exhibited substantial anticoagulant action at 1 mg/mL as opposed to saline the -ve control [66] formation of blood clots. It was conclusively proven that mycogenic AgNPs fiercely compete with the + ve control (EDTA), as seen in Figure 4a2, and the microscopic view also revealed evenly distributed red blood cells (Figure 4c2).…”

Section: Antithrombolytic Anticoagulant and Antiplatelet Activities O...mentioning

confidence: 99%

A Review of Antithrombolytic, Anticoagulant, and Antiplatelet Activities of Biosynthesized Metallic Nanostructured Multifunctional Materials

Emmanuel,

Adesibikan,

Olusola Olawoyin

et al. 2023

ChemistrySelect

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The continuous upsurge in drug resistance, the proliferation of life‐threatening aliment, and the advent of the utilization of biogenic extract for bio‐fabrication of metallic nanoparticles (MNPs) are unequivocally accidental. This review generously gathers the efficacy remarks of numerous biosynthesized MNPs concerning their antithrombolytic activity, Anticoagulant activity, and antiplatelet activity to give fresh thought to researchers on what to improve as per the architectural design of the biosynthesized MNPs, and selection of biogenic extract for better activities. In this work, efforts were made to provide mechanistic insight into the antithrombolytic, Anticoagulant, and antiplatelet activities of different biogenic MNPs. This work revealed that the biogenic extract used in synthesizing the green MNPs confers on them an improved biological activity compared to the physically and chemically synthesized MNP owing to the enormous phytochemicals present in the biological entities. Notably, it was also observed that phytogenically synthesized MNPs performed better than mycogenically synthesized MNPs and this might be ascribed to a large volume of the phytochemical present in plants that can easily be leached compared to microorganisms. Comparatively, the biogenic MNPs synergistically outperformed the ordinary biological extract and MNPs when used individually. Conclusively, from this review, the biosynthesized MNPs is a promising candidate for combating inflammation, the spread of infectious agents, retarded wound‐healing process, thrombosis, blood coagulation, ulcer, internal and external bleeding during injury with an average remarkable efficacy >70, and infinitesimal toxicity.

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Section: Antithrombolytic Anticoagulant and Antiplatelet Activities O...mentioning

confidence: 99%

A Review of Antithrombolytic, Anticoagulant, and Antiplatelet Activities of Biosynthesized Metallic Nanostructured Multifunctional Materials

Emmanuel,

Adesibikan,

Olusola Olawoyin

et al. 2023

ChemistrySelect

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“…[20] It was also observed that E. coli (ATCC 11229) and Staphylococcus epidermidis (ATCC 12228) were both significantly inhibited by plant-mediated synthetic AgNPs. [20] Various other uses of AgNPs are also possible. For instance, AgNPs synthesized with certain chemicals (acetic acid, ascorbic acid) and a solution of chitosan biopolymer as a stabilizing agent are in the treatment of dental caries.…”

Section: Introductionmentioning

confidence: 97%

“…(Table 1). [20] It was also observed that E. coli (ATCC 11229) and Staphylococcus epidermidis (ATCC 12228) were both significantly inhibited by plant‐mediated synthetic AgNPs [20] . Various other uses of AgNPs are also possible.…”

Section: Introductionmentioning

confidence: 99%

Recycling of Hazelnut Husk; from Bio‐waste to Phyto‐Assisted Synthesis of Silver Nanoparticles

Sivri,

Kurel,

Baytore

et al. 2023

ChemistrySelect

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In the present work, green synthesis is utilized in the synthesis of silver nanoparticles with hazelnut (Corylus Colurna) husk which is the outer leaf part of the hazelnut shell and is considered bio‐waste. According to transmission electron microscopy and x‐ray diffraction analysis, the morphology of the silver nanoparticles synthesized by 0.1 g/mL hazelnut husk extract is found to be spherical with an average diameter of 6.57 nm and possesses ultra‐narrow size distribution. UV‐visible spectrometry reveals the absorbance peak range between 450–475 nm which is in the range of surface plasmon resonance peak of silver nanoparticles with spherical morphology. Antibacterial properties of the synthesized silver nanoparticles were tested on E. coli and significant antimicrobial activity was found with up to 79 % areal inhibition efficiency. The research revealed that the hazelnut husk extract, a reducing agent used in syntheses with different mass concentrations of hazelnut husk extract, also affects the size of the nanoparticles, allowing for the possibility of controlling their size. The antibacterial properties of silver nanoparticles, synthesized in a spherical form of different sizes, correspondingly increased their effect on bacteria which is observed in the inhibition zone. The synthesis of silver nanoparticles, which can be used in many fields for agriculture, cosmetics, and medical purposes, using plant extract and minimal chemicals is crucial because it affects its toxicity. The synthesis of silver nanoparticles with hazelnut husk not only reduces the chemical waste and toxicity, but it is both easily accessible and helps the environment and sustainability by recycling a normally considered bio‐waste by‐product of high‐value‐added crop to a technologically valuable product silver. Moreover, synthesized silver nanoparticles could be an essential part of applications ranging from antibacterial surface treatments to drug delivery systems.

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“…Nanobiotechnology is a rapidly expanding field in biological sciences that has various applications in the health sector, particularly for the production of bioactive nanomaterials such as nanoparticles (NPs) and nanoconjugates for controlling several diseases. Green nanotechnology-based NPs and nanoconjugates have attracted huge interest because of their extensive biomedical applications [1][2][3]. NPs have shown promising results as alternative drugs for human diseases, including cancer, diabetes, wound healing and infectious diseases [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Biosynthesized NPs have several advantages, including less toxicity and high stability [11,15,16]. Moreover, the biosynthesized NPs show a wide range of biomedical applications such as antioxidant, antimicrobial, anti-inflammation and anti-cancer agents as well as promising carriers for various drug delivery systems [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Bacterial mediated green synthesis of silver nanoparticles and their antibacterial and antifungal activities against drug-resistant pathogens

Huq,

Khan,

Alshehri

et al. 2023

R. Soc. open sci.

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In the healthcare sector, the production of bioactive silver nanoparticles (AgNPs) with antimicrobial properties is of great importance. In this study, a novel bacterial strain, Paenibacillus sp. MAHUQ-63, was identified as a potential candidate for facile and rapid biosynthesis of AgNPs. The synthesized AgNPs were used to control the growth of human pathogens, Salmonella Enteritidis and Candida albicans . The bacterial culture supernatant was used to synthesize the nanoparticles (NPs). Field emission transmission electron microscope examination showed spherical-shaped NPs with 15–55 nm in size. Fourier transform-infrared analysis identified various functional groups. The synthesized AgNPs demonstrated remarkable activity against S. Enteritidis and C. albicans . The zones of inhibition for 100 µl (0.5 mg ml −1 ) of AgNPs against S. Enteritidis and C. albicans were 18.0 ± 1.0 and 19.5 ± 1.3 mm, respectively. The minimum inhibitory concentrations were 25.0 and 12.5 µg ml −1 against S. Enteritidis and C. albicans , respectively. Additionally, the minimum bactericidal concentrations were 25.0 µg ml −1 against both pathogenic microbes. The field emission scanning electron microscopy analysis showed that the treatment of AgNPs caused morphological and structural damage to both S. Enteritidis and C. albicans . Therefore, these AgNPs can be used as a new and effective antimicrobial agent.

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Bioinspired green-synthesized silver nanoparticles: in vitro physicochemical, antibacterial, biofilm inhibitory, genotoxicity, antidiabetic, antioxidant, and anticoagulant performance

Abstract: Green-synthesized nanobiomaterials, for instance silver nanoparticles (AgNPs), can be engineered as smart nanomedicine platforms for diagnostic and therapeutic purposes of various disorders including infectious diseases and cancer. In the present...

Cited by 20 publications

References 59 publications

A Review of Antithrombolytic, Anticoagulant, and Antiplatelet Activities of Biosynthesized Metallic Nanostructured Multifunctional Materials

A Review of Antithrombolytic, Anticoagulant, and Antiplatelet Activities of Biosynthesized Metallic Nanostructured Multifunctional Materials

Recycling of Hazelnut Husk; from Bio‐waste to Phyto‐Assisted Synthesis of Silver Nanoparticles

Bacterial mediated green synthesis of silver nanoparticles and their antibacterial and antifungal activities against drug-resistant pathogens

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