Bioinspired Electric Stimulation: Comparison of ECoG Spectrum in the Main Auditory Structures

Bianco, Maria Giovanna; Pullano, Salvatore A.; Menniti, D.; Critello, Costantino Davide; Citraro, Rita; Russo, Emilio; Sarro, Giovambattista De; Fiorillo, Antonino S.

doi:10.1109/memea.2019.8802150

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The acquired biopotentials were filtered using a finite impulse response bandpass filter (1 Hz – 100 Hz) [26]. Additionally, the power line interference of 50 Hz was nullified using a notch filter [27]. Similarly, by changing the frequency of a notch filter, power line interference of 60 Hz can be mitigated following electrical standards.…”

Section: Methodsmentioning

confidence: 99%

Design and fabrication of flexible biodegradable microelectrode array for recording electrocorticography signals

Chatterjee,

Joshi,

Bhaskara

et al. 2023

Preprint

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Conventional flexible implantable microelectrode arrays, used for real-time brain activity monitoring, incur minimal tissue damage due to their flexibility; however, these require retrieval surgery, causing trauma to subjects. Implants, fabricated using biodegradable materials, dissolve gradually in body fluid, eliminating the necessity for retrieval surgery. This work reports designing and developing a 10-channel flexible biodegradable microelectrode array to acquire electrocorticography signals from rats’ brains. The array was fabricated using tungsten, a transient metal, and PLLA:PCL (80:20), a biodegradable composite polymer. The subdural implantation of the array on the somatosensory cortex of rats (n=3) facilitated electrical biopotentials acquisition using OpenBCI Cyton Boards. The baseline activities, the induced epileptic discharges after peripheral electrical stimulation, and the recovered baseline activities after antiepileptic drug administration were recorded from sedated rats. The chronic baselines and evoked activities were also acquired from awake rats. The gradual decline of chronic baselines was evident, suggesting a possible dissolution of electrodes. Furthermore, the time-frequency analyses demonstrate the differences between baselines and induced epileptic activities. The signals recorded from microelectrode arrays demonstrate their potential to monitor brain activities in a chronic study. Histology of the harvested vital organs from the euthanized rats confirmed minimal tissue damage due to implantation.

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Section: Methodsmentioning

confidence: 99%

Design and fabrication of flexible biodegradable microelectrode array for recording electrocorticography signals

Chatterjee,

Joshi,

Bhaskara

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In recent years, neuroprostheses have shown great potential in the investigation of the dynamic circuits of the brain due to the advances in biomedical engineering, [1][2][3]. Neuroprostheses are commonly categorized according to the brain areas involved in motor, sensory, sensorimotor, and cognitive functions [4].…”

Section: Introductionmentioning

confidence: 99%

Neural Modulation of the Primary Auditory Cortex by Intracortical Microstimulation with a Bio-Inspired Electronic System

et al. 2020

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Nowadays, the majority of the progress in the development of implantable neuroprostheses has been achieved by improving the knowledge of brain functions so as to restore sensorial impairments. Intracortical microstimulation (ICMS) is a widely used technique to investigate site-specific cortical responses to electrical stimuli. Herein, we investigated the neural modulation induced in the primary auditory cortex (A1) by an acousto-electric transduction of ultrasonic signals using a bio-inspired intracortical microstimulator. The developed electronic system emulates the transduction of ultrasound signals in the cochlea, providing bio-inspired electrical stimuli. Firstly, we identified the receptive fields in the primary auditory cortex devoted to encoding ultrasonic waves at different frequencies, mapping each area with neurophysiological patterns. Subsequently, the activity elicited by bio-inspired ICMS in the previously identified areas, bypassing the sense organ, was investigated. The observed evoked response by microstimulation resulted as highly specific to the stimuli, and the spatiotemporal dynamics of neural oscillatory activity in the alpha, beta, and gamma waves were related to the stimuli preferred by the neurons at the stimulated site. The alpha waves modulated cortical excitability only during the activation of the specific tonotopic neuronal populations, inhibiting neural responses in unrelated areas. Greater neuronal activity in the posterior area of A1 was observed in the beta band, whereas a gamma rhythm was induced in the anterior A1. The results evidence that the proposed bio-inspired acousto-electric ICMS triggers high-frequency oscillations, encoding information about the stimulation sites and involving a large-scale integration in the brain.

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Flexible Microelectrode Array for Chronic Electrocorticography Recording under Different Neurophysiological Conditions

Chatterjee,

Joshi,

et al. 2023

2023 11th International IEEE/EMBS Conference on Neural Engineering (NER)

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Bioinspired Electric Stimulation: Comparison of ECoG Spectrum in the Main Auditory Structures

Cited by 3 publications

References 23 publications

Design and fabrication of flexible biodegradable microelectrode array for recording electrocorticography signals

Design and fabrication of flexible biodegradable microelectrode array for recording electrocorticography signals

Neural Modulation of the Primary Auditory Cortex by Intracortical Microstimulation with a Bio-Inspired Electronic System

Flexible Microelectrode Array for Chronic Electrocorticography Recording under Different Neurophysiological Conditions

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