Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution

Efficient scarless skin regeneration enabled by loading micronized amnion in a bioinspired adhesive wound dressing

“…On the 14th day after injury, wound healing would enter the stage of proliferation where M1 MACs transform into M2 MACs. [ 47 ] Of note, more M2‐type MACs were observed in our SSAD group (Figure 7B), suggesting that the wound healing effect of the SSAD group might be better than the control group. The numbers of M1 MACs in the two groups were basically equal.…”

“…[ 46 ] SDF‐1 alone can promote cell migration, and SSAD was found to promote cell migration better than SDF‐1 alone, suggesting that it might be the result of the combination of SSAD components in enhancing cellular behaviors. [ 47 ]…”

“…[46] SDF-1 alone can promote cell migration, and SSAD was found to promote cell migration better than SDF-1 alone, suggesting that it might be the result of the combination of SSAD components in enhancing cellular behaviors. [47] Interfollicular epidermis stem cells (IFESCs) are crucial stem cells recruited to the wound site to promote skin healing. [48] It takes approximately 1 week for IFESCs to be recruited and migrate to the wound, and then they remain in place for about 35 days from the recruitment to help with skin repair.…”

A multifunctional hydrogel dressing with high tensile and adhesive strength for infected skin wound healing in joint regions

“…4,5 As an emerging modern dressing, hydrogels have received extensive attention in wound healing and are expected to become an ideal wound dressing. [6][7][8] Hydrogels can effectively absorb tissue secretion at the wound site and maintain a moist environment surrounding the wound. [9][10][11] Moreover, by inserting functional groups or loading medicines, new functionalities can be obtained.…”

Underwater instant adhesion mechanism of self-assembled amphiphilic hemostatic granular hydrogel from Andrias davidianus skin secretion

“…Andrias davidianus belongs to the Cryptobranchidae family dating back to 350 million years ago and is the current largest aquatic amphibian ( Gao and Shubin, 2003 ; He et al., 2018 ; Hou et al., 2004 ; Murphy et al., 2000 ). Its skin secretions contain abundant bioactive compounds showed antibacterial behavior ( Guo et al., 2012 ; Wang et al., 2011 ), wound healing activities ( Xi et al., 2012 ), prohealing properties ( Dang et al., 2022 ), high hemostasis performance ( Zhang et al., 2022 ), and was used as wound dressing materials ( Liu et al., 2022a ). Apparently, like sandcastle worms building underwater “concretes” through particle aggregation ( Zhao et al., 2016 ), dry ADS particulates instantly glue together to form a hydrophobic water-insoluble hydrogel strongly bonding to wet substrates when contacting water ( Mao et al., 2020 ), showing impressive underwater contact adhesion behavior.…”