Bioinorganic Magnetic Core−Shell Nanocomposites Carrying Antiarthritic Agents: Intercalation of Ibuprofen and Glucuronic Acid into Mg−Al−Layered Double Hydroxides Supported on Magnesium Ferrite

Abstract

This paper describes the synthesis and characterization of a composite constituted by an antiarthritic agent (AA) intercalated into a layered double hydroxide (LDH) supported on magnesium ferrite. Core-shell nanocomposites were prepared by depositing Mg-Al-NO(3)-LDH on a MgFe(2)O(4) core prepared by calcination of a nonstoichiometric Mg-Fe-CO(3)-LDH. Intercalation of ibuprofen and glucuronate anions was performed by ion-exchange with nitrate ions. The structural characteristics of the obtained products were investigated by powder X-ray diffraction, element chemical analysis, Fourier transform infrared spectroscopy, and thermogravimetric analysis. Morphologies of the nanocomposite particles were examined by scanning electron microscopy and transmission electron microscopy. The products were shown to intercalate substantial amounts of AA with enhanced thermal stabilities. Room-temperature magnetic measurements by vibrating sample magnetometry revealed that the products show soft ferromagnetic properties suitable for potential utilization in magnetic arthritis therapy.

A novel injectable thermoresponsive and cytocompatible gel of poly(N-isopropylacrylamide) with layered double hydroxides facilitates siRNA delivery into chondrocytes in 3D culture

“…Other applications of LDHs as a drug carrier for degenerate cartilaginous conditions have included combination with NSAIDs or glucuronate acids to reduce inflammation or to serve as a supplement of exogenous glycosaminoglycans, respectively [70][71][72][73]. Moreover, a calcinated product of MgFe-LDH showing soft magnetic properties [74] could serve as a core to support another type of LDHs intercalating anti-inflammatory drugs [72,73,75].…”

“…Moreover, a calcinated product of MgFe-LDH showing soft magnetic properties [74] could serve as a core to support another type of LDHs intercalating anti-inflammatory drugs [72,73,75]. Such magnetic composites could be potentially used, with a combination of a magnetic field, as the media for target-guided controlled release.…”

Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

“…These showed excellent antimicrobial activities against planktonic bacteria and inhibited the formation of biofilms that could provide low cost and efficient antimicrobial inorganic coatings for various biomedical applications. In other interesting study Ay et al (2009) have reported nearly spherical core-shell magnesium ferrite@LDH nanoparticles carrying anti-arthritic agent, that have shown a true potential for magnetic arthritis therapy. Very recently, the same team developed prolate Fig.…”

Layered Double Hydroxide Materials in Photocatalysis

“…In this regard, magnetic separation is a very convenient approach for removing and recycling magnetic particles/composites. Recently, the combination of magnetic nanoparticles with LDHs has been developed to enhance separation and re-dispersion performance of LDHs in aqueous solution [65][66][67]. For instance, magnetic Fe 3 O 4 /ZnCr-LDH composite with a high saturation magnetization shows improved adsorption and photocatalytic activity [68].…”