Bioinformatics study of expression from genomes of epidemiologically related MRSA CC398 isolates from human and wild animal samples

Ribeiro, Miguel; Sousa, Margarida; Borges, Vítor; Gomes, João Paulo; Duarte, Sílvia; Isidro, Joana; Vieira, Luı́s; Torres, Carmén; Santos, Hugo M.; Capelo, José Luís; Poeta, Patrícia; Igrejas, Gilberto

doi:10.1016/j.jprot.2022.104714

Cited by 3 publications

(1 citation statement)

References 67 publications

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“…The role of wild animals in intra- and interfarm MRSA transmission is a matter rarely discussed [ 89 ]. Methicillin-resistant S. aureus strains have already been detected in multiple species of wild animals, e.g., boars, deers, hares, or hedgehogs [ 90 , 91 , 92 , 93 , 94 ]. Despite the wide genetic diversity of isolated MRSA, typical LA-MRSA strains like ST398 have also been detected.…”

Section: Transmission Of Animal-associated Staphylococcus A...mentioning

confidence: 99%

The Epidemiology of Animal-Associated Methicillin-Resistant Staphylococcus aureus

Kasela,

Ossowski,

Dzikoń

et al. 2023

Antibiotics

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Methicillin-resistant Staphylococcus aureus (MRSA) remains an important etiological factor of human and animal infectious diseases, causing significant economic losses not only in human healthcare but also in the large-scale farming sector. The constantly changing epidemiology of MRSA observed globally affects animal welfare and raises concerns for public health. High MRSA colonization rates in livestock raise questions about the meaning of reservoirs and possible transmission pathways, while the prevalence of MRSA colonization and infection rates among companion animals vary and might affect human health in multiple ways. We present the main findings concerning the circulation of animal-associated MRSA (AA-MRSA) in the environment and factors influencing the direction, mechanisms, and routes of its transmission. Studies have shown it that S. aureus is a multi-host bacterial pathogen; however, its adaptation mechanisms enabling it to colonize and infect both animal and human hosts are still rarely discussed. Finally, we elaborate on the most successful strategies and programs applied limiting the circulation of AA-MRSA among animals and humans. Although MRSA strains colonizing animals rarely infect humans, they undergo host-adaptive evolution enabling them to spread and persist in human populations.

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