Hypertension, a condition characterized by elevated blood pressure, poses a significant medical risk, particularly in relation to the development of cardiovascular disease. The
pathogenesis of hypertension can be influenced by a combination of genetic and environmental
factors. Recent scientific studies have shed light on the involvement of long-non-coding RNAs
(lncRNAs) in various diseases, including pulmonary arterial and essential hypertension. These
lncRNAs have been found to play crucial roles at the transcriptional, post-transcriptional, and
post-translational levels. By targeting endothelial cell proliferation, migration, apoptosis, and
angiogenesis, lncRNAs can induce dysfunction in arterial endothelial cells, contributing to the
progression of hypertension-related pathological events. Therefore, the abnormal expression of
lncRNAs has emerged as a significant factor in the understanding of essential hypertension and
its associated mechanisms. To further our understanding, we conducted a comprehensive review
focusing on unraveling the functional roles of lncRNAs in essential hypertension.