Abstract:Enzymes empower chemical industries and are the keystone for metabolic engineering. For example, linalool synthases (LSs) are indispensable for the biosynthesis of linalool, an important fragrance used in 60-80% cosmetic and personal care products. However, plant LSs have low activities while expressed in microbes. Aided by bioinformatics analysis, four linalool/nerolidol synthases (LNSs) from various Agaricomycetes were accurately predicted and validated experimentally. Furthermore, we discovered a novel LS w… Show more
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