BioImplantable Bone Stress Sensor

Alfaro, J. Fernando; Weiss, Lee E.; Campbell, Phil G.; Miller, Mark Carl; Heyward, C.; Doctor, John S.; Fedder, Gary K.

doi:10.1109/iembs.2005.1616462

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…In bone, biosensing devices could monitor mechanical strains indicative of bone loss, 4 the pressure and force patterns of bone being incorporated in a healing spinal fusion in vivo 5 and tissue engineering events. 6 Drug delivery devices in bone could be used for a controlled release of growth factors to allograft bone.…”

Section: Introductionmentioning

confidence: 99%

Osteogenesis of human mesenchymal stem cells on micro-patterned surfaces

et al. 2011

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Osteogenic responses of human mesenchymal stromal cells (hMSCs) were compared on square-patterned, inverse square-patterned, and planar titanium, chromium, diamond-like carbon (DLC), and tantalum; hypothesis was that both the materials and patterns affect osteogenesis. Samples were produced using photolithography and physical vapor deposition. Early-marker alkaline phosphatase (ALP) and mid-markers, small body size and mothers against decapentaplegic-related protein-1 (SMAD1), runt-related transcription factor-2 (RUNX2), and osteopontin were studied using quantitative real-time polymerase chain reaction. ALP and hydroxyapatite, were colorimetrically studied. ALP reached highest values on both patterned titanium samples, but mid-markers disclosed that it was already lagging behind planar and inverse patterned tantalum. Hydroxyapatite formation disclosed that osteo-induced hMSCs passed all the differentiation stages (except on planar chromium). Presence of hydroxyapatite disclosed that both types of patterning promoted (p < 0.001) osteogenesis compared to planar samples. Results suggest that the osseocompatibility/integration of implants could be improved by changing the monotonous and featureless implant-host interface into micro-patterned interface to provide physical differentiation cues.

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Section: Introductionmentioning

confidence: 99%

Osteogenesis of human mesenchymal stem cells on micro-patterned surfaces

et al. 2011

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“…These calcium and minerals are not synthesized by body but taken from food. If enough calcium is not taken in the diet, the stored calcium of bone is utilized for the proper functioning of the body, making bones weaker [13][14][15][16]. Metals and minerals such as phosphorus, calcium, magnesium, sodium, potassium, sulfur, iodine, iron, molybdenum, manganese, and zinc are very important for human health.…”

Section: Bone Diseasesmentioning

confidence: 99%

Advances in Sensing Technologies for Monitoring of Bone Health

et al. 2020

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Changing lifestyle and food habits are responsible for health problems, especially those related to bone in an aging population. Poor bone health has now become a serious matter of concern for many of us. In order to avoid serious consequences, the early prediction of symptoms and diagnosis of bone diseases have become the need of the hour. From this inspiration, the evolution of different bone health monitoring techniques and measurement methods practiced by researchers and healthcare companies has been discussed. This paper focuses on various types of bone diseases along with the modeling and remodeling phenomena of bones. The evolution of various diagnosis tests for bone health monitoring has been also discussed. Various types of bone turnover markers, their assessment techniques, and recent developments for the monitoring of biochemical markers to diagnose the bone conditions are highlighted. Then, the paper focuses on the potential assessment of the recent sensing techniques (physical sensors and biosensors) that are currently available for bone health monitoring. Considering the importance of electrochemical biosensors in terms of high sensitivity and reliability, specific attention has been given to the recent development of electrochemical biosensors and significance in real-time monitoring of bone health.

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“…We previously proposed a wireless microminiature intraosseous sensor system to measure multi-axis stresses at the microscale [18]. The conceptual design of the sensor, depicted in figure 1, includes a central MEMS transducer array, a surrounding coil antenna for wireless operation, and electronics, all integrated on a single 3 mm × 3 mm CMOS chip.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, coating the silicon with titanium further enhances osteoconductivity and biocompatibility [20,21]. Therefore before proceeding with detailed design of the transducer, we evaluated adult mesenchymal stem cell (hAMSC) and MG-63 cell attachment and differentiation responses in vitro to several surface topologies on prototype of silicon chips fabricated with deep reactive ion etching (DRIE) and coated with titanium [18]. Using these studies we determined that arrays of 60 μm square posts that are 60 μm tall and spaced 60 μm apart provided satisfactory results (see figure 2 for an example) [22].…”

Section: Introductionmentioning

confidence: 99%

Design of a multi-axis implantable MEMS sensor for intraosseous bone stress monitoring

Alfaro¹,

Weiss²,

Campbell³

et al. 2009

J. Micromech. Microeng.

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The capability to assess the biomechanical properties of living bone is important for basic research as well as the clinical management of skeletal trauma and disease. Even though radiodensitometric imaging is commonly used to infer bone quality, bone strength does not necessarily correlate well with these non-invasive measurements. This paper reports on the design, fabrication and initial testing of an implantable ultra-miniature multi-axis sensor for directly measuring bone stresses at a micro-scale. The device, which is fabricated with CMOS-MEMS processes, is intended to be permanently implanted within open fractures, or embedded in bone grafts, or placed on implants at the interfaces between bone and prosthetics. The stress sensor comprises an array of piezoresistive pixels to detect a stress tensor at the interfacial area between the MEMS chip and bone, with a resolution to 100 Pa, in 1 s averaging. The sensor system design and manufacture is also compatible with the integration of wireless RF telemetry, for power and data retrieval, all within a 3 mm × 3 mm × 0.3 mm footprint. The piezoresistive elements are integrated within a textured surface to enhance sensor integration with bone. Finite element analysis led to a sensor design for normal and shear stress detection. A wired sensor was fabricated in the Jazz 0.35 μm BiCMOS process and then embedded in mock bone material to characterize its response to tensile and bending loads up to 250 kPa.

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BioImplantable Bone Stress Sensor

Cited by 12 publications

References 4 publications

Osteogenesis of human mesenchymal stem cells on micro-patterned surfaces

Osteogenesis of human mesenchymal stem cells on micro-patterned surfaces

Advances in Sensing Technologies for Monitoring of Bone Health

Design of a multi-axis implantable MEMS sensor for intraosseous bone stress monitoring

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