Biohybrid Robot Powered by Muscle Tissues

Morimoto, Yuya; Takeuchi, Shoji

doi:10.1002/9783527822201.ch16

Cited by 5 publications

(5 citation statements)

References 78 publications

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“…Meanwhile, the heterogeneous stimulation refers to the response regarding to the external environment variation, such as humidity, pH, optical, electrical or thermal stimuli. 140 Based on different mechanisms, the hydrogel actuation could be categorized into osmotic actuation, 141 cell-powered actuation, 142 pneumatic/hydraulic actuation, 143 magnetic actuation 144 and acoustic actuation 145 . Different 3D printing techniques have been employed to fabricate the hydrogel actuators.…”

Section: Applications In Flexible Electronicsmentioning

confidence: 99%

Recent advances in the 3D printing of electrically conductive hydrogels for flexible electronics

et al. 2022

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Section: Applications In Flexible Electronicsmentioning

confidence: 99%

Recent advances in the 3D printing of electrically conductive hydrogels for flexible electronics

et al. 2022

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“…The design of skeletal muscle-based robotic devices generally implies the presence of a synthetic interface in the 3D culture, like a skeleton to the native muscle, to ensure the strain and mechanical integrity of the device. Therefore, most examples we find are biohybrid systems that fall into the soft robotic field, presenting flexible structures and moving in liquids containing the necessary nutrients and oxygen concentration, although a biohybrid robot moving in air has recently been reported [107].…”

Section: Skeletal Muscle-powered Devicesmentioning

confidence: 99%

Biohybrid robots: recent progress, challenges, and perspectives

Webster‐Wood

Guix

et al. 2022

Bioinspir. Biomim.

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The past ten years have seen the rapid expansion of the field of biohybrid robotics. By combining engineered, synthetic components with living biological materials, new robotics solutions have been developed that harness the adaptability of living muscles, the sensitivity of living sensory cells, and even the computational abilities of living neurons. Biohybrid robotics has taken the popular and scientific media by storm with advances in the field, moving biohybrid robotics out of science fiction and into real science and engineering. So how did we get here, and where should the field of biohybrid robotics go next? In this perspective, we first provide the historical context of crucial subareas of biohybrid robotics by reviewing the past 10+ years of advances in microorganism-bots and sperm-bots, cyborgs, and tissue-based robots. We then present critical challenges facing the field and provide our perspectives on the vital future steps towards creating autonomous living machines.

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“…Cells can be cultured as monolayers to drive bending-based actuation of bilayer cantilevers ( Marzban and Yuan, 2016 ; Chan et al, 2012 ; Ricotti and Fujie, 2017 ), or can be cultured as three dimensional tissues using casting ( Cvetkovic et al, 2014 ; Raman et al, 2016 ) or 3D printing ( Mestre et al, 2019 ). Although many example of mobile hydrogel devices are now available in the literature ( Ricotti et al, 2017 ; Webster-Wood et al, 2017 ; Sun et al, 2020 ; Morimoto and Takeuchi, 2020 ), challenges remain both in identification of optimal hydrogel composition and stiffness, and in scaling up cell-powered actuators for macro-scale applications ( Won et al, 2020 ). Despite these challenges, cell-powered actuation of hydrogels posses many unique advantages through the inclusion of material that is self-healing, renewable, and adaptable.…”

Section: Actuation Modalitiesmentioning

confidence: 99%

3D Printing Hydrogel-Based Soft and Biohybrid Actuators: A Mini-Review on Fabrication Techniques, Applications, and Challenges

et al. 2021

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Stimuli-responsive hydrogels are candidate building blocks for soft robotic applications due to many of their unique properties, including tunable mechanical properties and biocompatibility. Over the past decade, there has been significant progress in developing soft and biohybrid actuators using naturally occurring and synthetic hydrogels to address the increasing demands for machines capable of interacting with fragile biological systems. Recent advancements in three-dimensional (3D) printing technology, either as a standalone manufacturing process or integrated with traditional fabrication techniques, have enabled the development of hydrogel-based actuators with on-demand geometry and actuation modalities. This mini-review surveys existing research efforts to inspire the development of novel fabrication techniques using hydrogel building blocks and identify potential future directions. In this article, existing 3D fabrication techniques for hydrogel actuators are first examined. Next, existing actuation mechanisms, including pneumatic, hydraulic, ionic, dehydration-rehydration, and cell-powered actuation, are reviewed with their benefits and limitations discussed. Subsequently, the applications of hydrogel-based actuators, including compliant handling of fragile items, micro-swimmers, wearable devices, and origami structures, are described. Finally, challenges in fabricating functional actuators using existing techniques are discussed.

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Biohybrid Robot Powered by Muscle Tissues

Cited by 5 publications

References 78 publications

Recent advances in the 3D printing of electrically conductive hydrogels for flexible electronics

Recent advances in the 3D printing of electrically conductive hydrogels for flexible electronics

Biohybrid robots: recent progress, challenges, and perspectives

3D Printing Hydrogel-Based Soft and Biohybrid Actuators: A Mini-Review on Fabrication Techniques, Applications, and Challenges

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