BioGlue: Albumin/Glutaraldehyde Sealant in Cardiac Surgery

Chao, Hung-Hsing; Torchiana, David F.

doi:10.1046/j.0886-0440.2003.00304.x

Cited by 135 publications

(89 citation statements)

References 10 publications

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“…7 By contrast, naturally based fibrin adhesives, while less reactive and more biocompatible, have insufficient adhesive strength. 3,4,[9][10][11] To overcome these limitations, various adhesives based on epoxides, 12 polymethacrylates, 12 gelatin-resorcinol-aldehydes, 3,13 protein-aldehydes, 14 mussel adhesive proteins 3,15,16 as well as oligoand polylactones 17,18 were developed. Additionally, isocyanate-based adhesives are under consideration.…”

Section: Introductionmentioning

confidence: 99%

Development of a biodegradable tissue adhesive based on functionalized 1,2‐ethylene glycol bis(dilactic acid). II.

et al. 2011

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In body regions where damage and bleeding must be avoided, a substitute for mechanical tissue fixation by sutures or staplers is needed. Since tissue adhesives provide easy and fast handling they are a promising alternative. The present study reports the development and analysis of a tissue adhesive that consists of two adhesive components: hexamethylene diisocyanate (HDI) functionalized 1,2-ethylene glycol bis(dilactic acid) (ELA-NCO) and chitosan chloride. This composition was chosen based on preliminary studies on several chain elongation agents. The present study evaluates this adhesive system by IR-spectroscopy, tensile tests, and gel point measurements in comparison to fibrin glue. The system's in vitro biocompatibility was tested with mouse fibroblasts (L929) according to ISO 10993-5. Furthermore, an implantation study was performed in SPF-Wistar rats. The adhesive strength of manually applied mixtures or mixtures applied by double chamber syringes with a mixing extruder was determined to be significantly higher than that of fibrin glue on bovine muscle tissue at 37°C. Tensile strength increased further when exposure time of the adhesive was increased from 10 min to 48 h. The rheological gel point determination showed that the mixture of ELA-NCO/DMSO and chitosan chloride offers a time window large enough to readjust the fused joint during surgery, as opposed to fibrin glue. Additionally, the in vitro and in vivo biocompatibility studies of the adhesive system revealed no toxic effects on the surrounding tissue.

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Section: Introductionmentioning

confidence: 99%

Development of a biodegradable tissue adhesive based on functionalized 1,2‐ethylene glycol bis(dilactic acid). II.

et al. 2011

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“…Bonding strength reaches its maximum at 2 min. In vivo and ex vivo tensile and shear strength studies have been performed to show excellent bonding strength to tissues [162]. BioGlue has been used extensively to aid hemostasis in cardiovascular surgery [163].…”

Section: Gelatin Resorcinolmentioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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“…4.7 ) [ 46 ] . It was approved by the US FDA in 1999 for use during surgical repair of acute thoracic aortic dissection and in 2001 for general use as a hemostatic adjunct in cardiac and vascular surgery.…”

Section: Albumin-based Gluementioning

confidence: 98%

Sealants (Adhesives) to Prevent Bleeding

Suzuki

Ikada

2011

Biomaterials for Surgical Operation

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In general, surgical sealants (adhesives) are liquids and form gels when applied. Currently, several products are clinically available, including naturally derived fi brin sealants, semisynthetic products such as gelatin and albumin-based glues, and synthetic products including cyanoacrylates and poly(ethylene glycol). These products, however, have both advantages and disadvantages. While fi brin sealants have been successfully used in many surgical fi elds, they have several disadvantages including low adhesive strength. Other products, such as cyanoacrylates and protein-based products, have high adhesion strength but have high toxicity, and therefore, their applications are limited. Studies are still ongoing in order to develop sealants with higher adhesion strength and safer properties compared to the sealants that are currently available. This chapter reviews the chemistry and applications of clinically available sealants and recent developments in this fi eld.

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BioGlue: Albumin/Glutaraldehyde Sealant in Cardiac Surgery

Cited by 135 publications

References 10 publications

Development of a biodegradable tissue adhesive based on functionalized 1,2‐ethylene glycol bis(dilactic acid). II.

Development of a biodegradable tissue adhesive based on functionalized 1,2‐ethylene glycol bis(dilactic acid). II.

Tissue adhesives in ocular surgery

Sealants (Adhesives) to Prevent Bleeding

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