Bioglass in Alveolar Bone Regeneration in Orthodontic Patients

Shazley, N. El; Hamdy, Ahmed; El-Eneen, H.A.; Backly, Rania M. El; Saad, Manal M.; Essam, Wafaa; Moussa, Hassan; Tantawi, Maha El; Jain, Himanshu; Marei, Mona K.

doi:10.1177/2380084416660672

Cited by 26 publications

(26 citation statements)

References 37 publications

(43 reference statements)

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“…Samples were aged at 40°C for 1 day and then soaked in ammonia solution for 3 days before they were dried and thermally stabilized at 700°C. 30 TAMP-BG was ground to a fine powder and sieved to achieve 180-300 mm particles. The preparation of (TAMP-BG) hydrogel was performed by the same method as for DAP where 5,000 mg of (TAMP-BG) powder was added to 50 mL of sterile water and then 4 g of MC powder was added to obtain TAMP-BG with 100 mg/mL concentration.…”

Section: Antimicrobial Preparationmentioning

confidence: 99%

“…In addition to being biocompatible, TAMP-BG has been previously shown to enhance hard tissue regeneration in a recently published clinical trial. 30 This fact coupled with the demonstrated antimicrobial properties of TAMP-BG may further urge this material to be used as a potential scaffold for dentin/pulp regeneration for REPs. 60 Also, this is the first study to use TAMP-BG suspended in water soluble vehicle (MC). This form was used to ease the delivery and removal of TAMP-BG rather than using it as a slurry paste and also to enhance TAMP-BG degradation and liberation of Ca, Si, and P ions.…”

Section: Assessment Of the Residual Biofilm Structure (Sem Analysis)mentioning

confidence: 99%

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Evaluation of the Efficacy of Three Antimicrobial Agents Used for Regenerative Endodontics: AnIn VitroStudy

Sadek¹,

Moussa

Backly

et al. 2019

Microbial Drug Resistance

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To evaluate the antibacterial efficacy of double antibiotic paste (DAP), silver nanoparticle (AgNP) gel, and tailored amorphous multiporous bioactive glass (TAMP-BG) in concentrations suitable for regenerative endodontics (RE) against 3-week-old Enterococcus faecalis biofilms after 24 hours and 7 days. Results: Radicular human dentin specimens were prepared and inoculated with E. faecalis to form 3-week-old biofilms. DAP (1 mg/mL), AgNPs 0.02%, and TAMP-BG 100 mg/mL, in methylcellulose gel formulations, were used as antimicrobials. The biofilm disruption assay was done followed by quantification of bacterial colony-forming units and scanning electron microscopic analysis. Results showed that 1 mg/mL of DAP or AgNPs 0.02% provided significant antibiofilm effects at both time intervals. Both DAP and AgNPs significantly reduced bacterial counts and biofilms after 7 days compared with 24 hours. Furthermore, 100 mg/mL of TAMP-BG had a comparable antibiofilm effect, but it was less potent than DAP and AgNPs at both time intervals. Conclusions: DAP (1 mg/mL), 0.02% AgNPs, and TAMP-BG (100 mg/mL) can significantly reduce E. faecalis biofilms. However, complete elimination was only possible with DAP and AgNPs.

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Section: Antimicrobial Preparationmentioning

confidence: 99%

Section: Assessment Of the Residual Biofilm Structure (Sem Analysis)mentioning

confidence: 99%

Evaluation of the Efficacy of Three Antimicrobial Agents Used for Regenerative Endodontics: AnIn VitroStudy

Sadek¹,

Moussa

Backly

et al. 2019

Microbial Drug Resistance

View full text Add to dashboard Cite

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“…Moreover, in a clinical trial to evaluate the effect of bioactive glass scaffold for the preservation of alveolar bone following tooth extraction, it was found that bioactive glass scaffolds appeared to enhance the recruitment of stem cells from the grafted sockets. They concluded that bioglass scaffolds appeared to preserve alveolar bone following extraction and allow for a more active bone modeling and remodeling process (38) .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Alveolar Ridge Preservation Using a composite of Bioactive Glass and Platelet Rich Fibrin Alone or Combined with Melatonin in Chronic Periodontitis Patient

2018

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Purpose: The aim of this randomized controlled clinical trial was the evaluation of alveolar ridge preservation using a composite of bioactive glass and platelet rich fibrin either alone or combined with melatonin in chronic periodontitis patients. This aim was fulfilled through: Clinical assessment and radiographic assessment. Subjects and Methods: A total of thirty extraction sockets in 29 patients were randomly divided into three groups; control group treated by atraumatic extraction alone, test1 group (application of bioactive glass mixed with PRF) and test 2 group (application of bioactive glass mixed with PRF and melatonin gel). The clinical parameters recorded at baseline, 3 months and 6 months after treatment. Cone beam tomography radiographs used to measure width of socket at base line and 6months post operatively. Results: By clinical assessment both group II and group III showed significant increase in length and width of alveolar ridge with significant difference between the two groups in the whole study period. Radiographically; both group II and group III showed a significant increase in all parameters by time, while control group, there was a significant decrease at the end of the study period. Conclusion: Within the limits of this study: The composite use of bioglass, Prf & melatonin in group III reflected the best clinical, and radiographic results.

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“…In another clinical study, bioactive glass having both nanopores and micropores showed that alveolar bone remodeling was improved at the pocket resulting from tooth extraction. The addition of nanopores within the structure contributed to increase the surface area and therefore, to the dissolution whose products participate in the remodeling process [ 230 ]. A SAP-based hydrogel named P 11 -4 showed to behave as a nucleation agent in the formation of hydroxyapatite and showed in caries lesion treatments, enamel regeneration in humans [ 231 ], this same system also promoted regeneration of rat bone cranial defects after 6 weeks [ 232 ].…”

Section: In Vivo Outcomes and Clinical Trialsmentioning

confidence: 99%

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

2020

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Porous scaffolds have been employed for decades in the biomedical field where researchers have been seeking to produce an environment which could approach one of the extracellular matrixes supporting cells in natural tissues. Such three-dimensional systems offer many degrees of freedom to modulate cell activity, ranging from the chemistry of the structure and the architectural properties such as the porosity, the pore, and interconnection size. All these features can be exploited synergistically to tailor the cell–material interactions, and further, the tissue growth within the voids of the scaffold. Herein, an overview of the materials employed to generate porous scaffolds as well as the various techniques that are used to process them is supplied. Furthermore, scaffold parameters which modulate cell behavior are identified under distinct aspects: the architecture of inert scaffolds (i.e., pore and interconnection size, porosity, mechanical properties, etc.) alone on cell functions followed by comparison with bioactive scaffolds to grasp the most relevant features driving tissue regeneration. Finally, in vivo outcomes are highlighted comparing the accordance between in vitro and in vivo results in order to tackle the future translational challenges in tissue repair and regeneration.

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Bioglass in Alveolar Bone Regeneration in Orthodontic Patients

Cited by 26 publications

References 37 publications

Evaluation of the Efficacy of Three Antimicrobial Agents Used for Regenerative Endodontics: AnIn VitroStudy

Evaluation of the Efficacy of Three Antimicrobial Agents Used for Regenerative Endodontics: AnIn VitroStudy

Evaluation of Alveolar Ridge Preservation Using a composite of Bioactive Glass and Platelet Rich Fibrin Alone or Combined with Melatonin in Chronic Periodontitis Patient

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

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