Bioglass: A novel biocompatible innovation

Krishnan,; Lakshmi, T

doi:10.4103/2231-4040.111523

Cited by 311 publications

(131 citation statements)

References 33 publications

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“…The formation of apatite layer promotes the adhesion of bone tissues to the implant and enhances bone repair or reconstruction [93]. When compared with synthetic hydroxyapatite, bioactive glasses offer superior properties such as gene activation, high level of bioactivity, and a better bone regenerative capability [94]. This section briefly covers the physical and biological properties of bioactive glasses.…”

Section: Chemical Compositionmentioning

confidence: 99%

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

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Critical-sized bone defects have, in many cases, posed challenges to the current gold standard treatments. Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics; however, the difficulty in producing porous scaffolds made of bioactive glasses has limited their extensive use in bone regeneration. On the other hand, calcium phosphate ceramics such as synthetic hydroxyapatite and tricalcium phosphate are widely used in the clinic, but they stimulate less bone regeneration. This paper gives an overview of the recent developments in the field of bioactive nanoparticles, with a focus on nanohydroxyapatite and bioactive glasses for bone repair and regeneration. First, a brief overview of the chemical structure and common methods used to produce synthetic nanohydroxyapatite and bioactive glasses has been presented. The main body of the paper covers the physical and biological properties of these biomaterials, as well as their composites with biodegradable polymers used in bone regeneration. A summary of existing challenges and some recommendations for future directions have been brought in the concluding section of this paper.

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Section: Chemical Compositionmentioning

confidence: 99%

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Yousefi

Oudadesse

Akbarzadeh

et al. 2014

Nanotechnology Reviews

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“…11,12 By dissolving in the surrounding fluid, bioactive glasses also resorb in vivo. 6,13,14 Thus, by combining these two families of materials, fully bioresorbable scaffolds with remarkable mechanical and bioactive properties can be produced. However, biodegradation is a complex mechanism influenced by several biological connected factors, as for example fluid pH and infiltration, oxygen supply, and enzyme activity, 15,16 so an exact control of the process is difficult to achieve, especially if it aims to satisfy precise expectations, such as a specific degradation rate or a time-scaled product release.…”

Section: Introductionmentioning

confidence: 99%

Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Sachot¹,

Roguska²,

Planell³

et al. 2017

IJN

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The success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the graft surface and, more precisely, on its capacity to biodegrade in a well-defined manner (nature of ions released, surface-to-volume ratio, dissolution profile of this release, rate of material resorption, and preservation of mechanical properties). The assessment of the biological behavior of temporary templates is therefore very important in tissue engineering, especially for composites, which usually exhibit complicated degradation behavior. Here, blended polylactic acid (PLA) calcium phosphate ORMOGLASS (organically modified glass) nanofibrous mats have been incubated up to 4 weeks in physiological simulated conditions, and their morphological, topographical, and chemical changes have been investigated. The results showed that a significant loss of inorganic phase occurred at the beginning of the immersion and the ORMOGLASS maintained a stable composition afterward throughout the degradation period. As a whole, the nanostructured scaffolds underwent fast and heterogeneous degradation. This study reveals that an angiogenic calcium-rich environment can be achieved through fast-degrading ORMOGLASS/PLA blended fibers, which seems to be an excellent alternative for guided bone regeneration.

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“…Calcium chloride or calcium carbonate nanoparticles (topical application and intravenous injection) and calcium phosphate particles (local injection and as cream for topical application) have demonstrated the potential of calcium delivery to improve wound healing. Calcium‐containing bioactive glasses have been studied for different kinds of applications (drug delivery agent, bone tissue engineering, antibacterial agent, etc …”

Section: Calciummentioning

confidence: 99%

Bioinorganics and Wound Healing

Dalisson

Barralet

2019

Adv Healthcare Materials

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Wound dressings and the healing enhancement (increasing healing speed and quality) are two components of wound care that lead to a proper healing. Wound care today consists mostly of providing an optimal environment by removing waste and necrotic tissues from a wound, preventing infections, and keeping the wounds adequately moist. This is however often not enough to re-establish the healing process in chronic wounds; with the local disruption of vascularization, the local environment is lacking oxygen, nutrients, and has a modified ionic and molecular concentration which limits the healing process. This disruption may affect cellular ionic pumps, energy production, chemotaxis, etc., and will affect the healing process. Biomaterials for wound healing range from simple absorbents to sophisticated bioactive delivery vehicles. Often placing a material in or on a wound can change multiple parameters such as pH, ionic concentration, and osmolarity, and it can be challenging to pinpoint key mechanism of action. This article reviews the literature of several inorganic ions and molecules and their potential effects on the different wound healing phases and their use in new wound dressings.

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Bioglass: A novel biocompatible innovation

Cited by 311 publications

References 33 publications

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Bioinorganics and Wound Healing

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