Biogeographical Landscape of the Human Face Skin Microbiome Viewed in High Definition

Brandwein, Michael; Fuks, Garold; Israel, Avigail; Hodak, Emmilia; Sabbah, Farid; Steinberg, Doron; Bentwich, Zvi; Shental, Noam; Meshner, Shiri

doi:10.2340/00015555-3929

Cited by 2 publications

(3 citation statements)

References 35 publications

(34 reference statements)

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“…hydration levels and microbiome diversity has been shown. [85][86][87][88] Furthermore, skin care has shown to be of benefit both to microbiome and epidermal barrier function in a stress model and dry and flaky skin conditions. 7,89…”

Section: Immunologic Neurosensory and Skin Microbiome Considerations ...mentioning

confidence: 99%

“…The skin microbiome demonstrates specific patterns in hydrated areas and regions rich in sebum 82–84 . In the facial region, a specific relationship between sebum, hydration levels and microbiome diversity has been shown 85–88 . Furthermore, skin care has shown to be of benefit both to microbiome and epidermal barrier function in a stress model and dry and flaky skin conditions 7,89 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Fluhr,

Moore,

Lane

et al. 2023

Acad Dermatol Venereol

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The stratum corneum (SC)—the outermost layer of the epidermis—is the principal permeability and protective barrier of the skin. Different components of the SC, including corneocytes, natural moisturizing factor, a variety of enzymes and their inhibitors, antimicrobial peptides and lipids, work interactively to maintain barrier function. The main barrier properties of the SC are the limitation of water loss and the prevention of infection and contact with potentially harmful exogenous factors. Although the SC functions consistently as a protective barrier throughout the body, variations in functions and morphology occur across body sites with age and skin type. Healthy SC function also depends on the interplay between the chemosensory barrier, the skin's microbiome and the innate immune system. Dysregulation of SC barrier function can lead to the development of skin disorders, such as dry, flaky or sensitive skin, but the complete underlying pathophysiology of these are not fully understood. This review provides insight into the current literature and emerging themes related to epidermal barrier changes that occur in the context of dry, flaky and sensitive skin. Additional studies are needed to further elucidate the underlying aetiology of dry, flaky and sensitive skin and to provide tailored treatment.

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Section: Immunologic Neurosensory and Skin Microbiome Considerations ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Fluhr,

Moore,

Lane

et al. 2023

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…The skin microbiome has been characterized by specific patterns in highly hydrated areas and sebum-rich areas [27][28][29]. The relation of sebum and hydration levels with microbiome diversity was confirmed specifically in the facial region [30][31][32][33]. The use of an emollient in infants at risk for atopic dermatitis decreased the surface pH and subsequently increased the proportion of Streptococcus salivarius [34].…”

Section: Introductionmentioning

confidence: 96%

Acidic Skin Care Promotes Cutaneous Microbiome Recovery and Skin Physiology in an Acute Stratum Corneum Stress Model

Fluhr¹,

Menzel²,

Schwarzer³

et al. 2022

Skin Pharmacol Physiol

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Introduction: Skin microbiome and skin physiology are important indicators of the epidermal homeostasis status. Stress models can reveal pathological conditions and modulating effects. Here we investigated the cutaneous microbiome in relation to skin physiology after mild tape stripping (TS) without treatment compared to two cosmetic leave-on lotions (pH 5.5 vs. pH 9.3) in 25 healthy volunteers. Methods: The microbiome was analyzed by 16S-rRNA-gene amplicon sequencing and put in relation to the following skin physiology parameter: epidermal barrier function (TEWA-Meter TM300), stratum corneum hydration (Corneometer CM 825), surface pH (pH-Meter) and skin erythema (Mexameter). Results: TS reduced the alpha diversity with a recovery over 7 days without treatment. Both lotions significantly accelerated the recovery of the alpha-diversity already after 2 days with a slightly higher rate for the acidic lotion. After TS, the relative abundance of Proteobacteria was increased, whereas Actinobacteria were reduced. The relative abundances of typical skin-associated genera were reduced after TS. Taxa compositions returned to normal levels after 7 days in all treatment groups. An accelerated normalization could be observed with both lotions already after two days. A significant difference in skin pH was observed on day2 and day7 with an increased pH for the alkaline lotion. Both lotions induced an increase in stratum corneum hydration. Conclusion: The study proved the suitability of an experimental stress model in the assessment of skin surface microbiome in relation to skin physiology. Stratum corneum hydration increased significantly with both lotions already at day2. Microbiome parameters (alpha-diversity, mean relative taxa, abundance of selected genera) normalized over 2-7 days. The following mechanisms could be responsible for the accelerated normalization of the microbiome: a) optimized hydration during the recovery phase, b) the composition of the lotion c) the induced repair mechanism. Thus, the formulation has a positive effect on the stratum corneum hydration and subsequently on cutaneous microbiome and skin physiology. Furthermore, this has eventually implications in the modulation of exogenous stress-induced epidermal alterations.

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Biogeographical Landscape of the Human Face Skin Microbiome Viewed in High Definition

Cited by 2 publications

References 35 publications

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Acidic Skin Care Promotes Cutaneous Microbiome Recovery and Skin Physiology in an Acute Stratum Corneum Stress Model

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